Research Stories

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A team of researchers from City University of Hong Kong (CityU) and Karolinska Institutet has recently developed a new protein that can help increase the targeting accuracy in the genome editing process. It is believed that it would be useful for future gene therapies in human which require high precision.
A weapon to make a superbug to become more deadly
A recent research led by a scientist at City University of Hong Kong (CityU) has discovered an easily transmitted DNA piece that can make a new type of hyper-resistant and deadly superbug become hyper-virulent quickly, posing an unprecedented threat to human health.
The controllable activation property and superior antitumor activity of phorbiplatin significantly contributes to the development of photoactivatable anticancer prodrugs, especially Pt(IV) prodrugs that can be activated by red light, to reduce the adverse effects and conquer drug resistance of traditional platinum chemotherapy.
Most of the current clinical anti-tumor drugs used in chemotherapy move around in the patient's blood after intake and are unable to pinpoint the targeted tumor. As a result, while killing the tumor cells, the healthy cells may also be killed as “collateral damage", leading to undesired side effects. Aiming to overcome this problem, Dr Zhu Guangyu, Associate Professor of Department of Chemistry, City University of Hong Kong (CityU) and his research team have recently developed phorbiplatin, an anti-cancer prodrug that can be controllably activated by red light. With its unique “on-site” activation characteristic, it will effectively kill cancer cells and minimize damage to normal tissues.
Dr Ng, CityU
The contributions of an environmental scientist of City University of Hong Kong (CityU) to the field of photoelectrocatalysis have made him the only winner of the 2019 Asia-Pacific Economic Cooperation (APEC) Science Prize for Innovation, Research and Education (ASPIRE).
Dr Ban Kiwon’s team used rats’ hearts to carry out their research. These are the specimens of rats’ hearts.
As a medical emergency caused by severe cardiovascular diseases, myocardial infarction (MI) can inflict permanent and life-threatening damage to the heart. A joint research team comprising scientists from City University of Hong Kong (CityU) has recently developed a multipronged approach for concurrently rejuvenating both the muscle cells and vascular systems of the heart by utilizing two types of stem cells. The findings give hope to develop a new treatment for repairing MI heart, as an alternative to the existing complex and risky heart transplant for seriously-ill patients.
Droplet transport by surface charge density gradient
Transporting droplets on solid surfaces at high speed and long distance, even against gravity, without additional force has been a formidable task. But a research team comprising scientists from City University of Hong Kong (CityU) and three other universities and research institutes has recently devised a novel mechanism to transport droplets at record-high velocity and distance without extra energy input, and droplets can be moved upward along a vertical surface, which has never been achieved before. The new strategy to control droplet motion can open up new potential in applications in microfluidic devices, bio-analytical devices and beyond.
Pseudomonas aeruginosa, a superbug classified as one of the three “critical priority pathogens” that new drugs are urgently needed.
As antibiotic resistance is growing and posing a threat on public health, developing new antibiotics has become more urgent than ever. Researchers at City University of Hong Kong (CityU) have recently revealed the virulence regulatory mechanism in Pseudomonas aeruginosa, a superbug which is common in patients with a weak immune system and is resistant to many antibiotics. The findings pave ways for identifying good antibiotic targets for new drug development.
The team has managed to achieve the multiphoton conversion emission with a large anti -Stokes shift and a high energy conversion efficiency over 5%.
In the world of nanomaterials, when the “upconversion luminescence” material is excited by low-energy light, it can emit high-energy light, such as ultraviolet light. However, the emission intensity is not satisfied and hence limiting the further applications in different fields. A research team jointly led by the Materials Science and Engineering and Physics departments of City University of Hong Kong (CityU) has proposed a new strategy and successfully achieved upconversion luminescence with high energy conversion efficiency. The team believes that the research result will help further development and applications in miniaturized optoelectronic devices.
Images of letter “A” in dye, acquired at eight different wavelengths and at four different time delays by CUST photography
Acquiring images of ultrafast processes is a technology vitally needed for many cutting-edge physical, chemical, and biological studies. The latest research conducted by City University of Hong Kong (CityU) and Xi’an Jiaotong University has successfully developed a novel compressed ultrafast photographic technique, enabling both an ultra-high frame rate and a large frame number. Having overcome the existing limitations, the new technique offers an important tool for observing complex transient processes on the femtosecond (10-15second) timescale.
Exceptional point
A research team comprising physicists from City University of Hong Kong (City U) and other universities has successfully achieved a physical phenomenon called “exceptional point” using a simple resonator system. The recent findings provide the foundation for developing ultrasensitive optical sensors in the future.
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