|Address:||Room 1B-411, 4/F, Block 1, To Yuen Building, 31 To Yuen Street
City University of Hong Kong
Research profile: CityU Scholars
Dr KIM Dal Young joined the Jockey Club College of Veterinary Medicine and Life Sciences in July 2018 as an Assistant Professor in Veterinary Virology in the Department of Infectious Diseases and Public Health.
He obtained a Doctor of Veterinary Medicine (DVM) Degree from Chungbuk National University in South Korea and then worked for two years as a Veterinary Officer at the National Veterinary Research and Quarantine Service (NVRQS) institution in South Korea. He completed a PhD degree at the College of Veterinary Medicine (Department of Pathobiology) at Kansas State University, USA. His PhD project was “Live attenuated marker vaccine development of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) using a multifunctional nsp2 domain”.
During his postdoctoral training period, he switched his research focus to mosquito-borne flaviviruses such as West Nile/Dengue/Yellow fever viruses and performed research at the Department of Microbiology and Immunology of the University of Texas Medical Branch at Galveston, USA. After relocation to the Department of Microbiology at the University of Alabama in Birmingham, USA, he worked in a variety of public health research projects related to the arbovirus group. He was involved in zoonotic alphavirus research including the development of live attenuated chimeric Chikungunya virus (CHIKV) vaccine candidates, the biochemical characterisation of the conserved packaging signal of all alphavirus lineages, the development of an enhanced version of the Venezuelan equine encephalitis virus (VEEV) based replicon system and its application in vivo, identification of new host proteins that provide an efficient ground as replication complex formation for the genomic replication of VEEV and Eastern equine encephalitis virus (EEEV) etc.
KIM’s research will be focusing on the elucidation of molecular mechanisms of zoonotic viral pathogens that can provide the groundworks for the development of therapeutic methods. He is devoted to producing a universal delivery vehicle by utilising uncharacterised viruses that will be an efficient platform for the generation of pseudoinfectious viruses (PIV) that can become next generation vaccine candidates.
Please click HERE for a full list of publications
Ilya Frolov, Kim DY, Maryna Akhrymuk, James A. Mobley, Elena I Frolova. Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex Assembly. Journal of Virology 2017 May 3. pii: JVI.00371-17. doi: 10.1128/JVI.00371-17. (Selected as a spotlight paper in current issue)
Jesse H. Erasmus, Albert J. Auguste, Jason T. Kaelber, Shannan L. Rossi, Karla Fenton, Grace Leal, Kim DY, Huanle Luo, Wah Chiu, Tian Wang, Ilya Frolov, Farooq Nasar, Scott C. Weaver. A chikungunya fever vaccine utilizing an insect-specific virus platform. Nat Med. 2017 Feb; 23(2): 192-199
Kim DY, Josephine M Reynaud, Aliaksandra Rasalouskaya, Ivan Akrimuk, James A. Mobley, Ilya Frolov, Elena I. Frolova. New World and Old World Alphaviruses have evolved to exploit different components of stress granules, FXR and G3BP proteins, for assembly of RNA replication complexes. PLOS Pathogens 2016 Aug 10;12(8):e1005810. doi: 10.1371/journal.ppat.1005810. eCollection 2016 Aug.
Josephine M Reynaud, Valeria Lulla, Kim DY, Elena I Frolova, Ilya Frolov. The SD1 subdomain of Venezuelan Equine Encephalitis Virus Capsid Protein Plays a Critical Role in Nucleocapsid and Particle Assembly. Journal of Virology. 2016 Feb 90(4) : 2008-2020
Jesse H Erasmus, James Needham, Syamal Raychaudhuri, Michael S Diamond, David WC Beasley, Stan Morkowski, Henrik Salje, IIdefonso Fernandez Salas, Kim DY, Ilya Frolov, Farooq Nasar, Scott C Weaver. Utilization of an Eilat Virus-Based Chimera for Serological Detection of Chikungunya infection. PLOS Neglected Tropical Diseases. 2015 Oct 22;9(10): e0004119. doi: 10.1371/journal.pntd.0004119
Josephine M Reynaud*, Kim DY*, Svetlana Atasheva, Aliaksandra Rasalouskaya, Michael S Diamond, Scott C Weaver, Elena I Frolova, Ilya Frolov. IFIT1 Differentially Interferes With Translation and Replication of Alphavirus Genome and Promote Induction of Type I Interferon. PLOS Pathogens 2015 Apr 30;11(4): e1004863. doi:10.1371/journal.ppat.1004863 (* co-first author)
Svetlana Atasheva, Kim DY, Elena I. Frolov, Ilya Frolov. Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype. Journal of Virology. 2015 Jan 1;89(1): 71-82