CBM Research Seminar – Cell Surface Chemical Biology and Translational Medicine Enabled by Chimeric Molecules

The College of Biomedicine was pleased to host Professor Ben Wang from Institute of Translational Medicine, Zhejiang University, as a distinguished speaker on 9 March 2026. Professor Wang's research focuses on cell surface chemical biology, integrating chemical, biological, and engineering methodologies to develop innovative early disease diagnostics and personalized therapeutic interventions.

In his talk entitled "Cell Surface Chemical Biology and Translational Medicine Enabled by Chimeric Molecules", Professor Wang discussed the pivotal role of the cell surface as the interface for substance exchange, signal transduction, and energy transfer across cellular membranes. He highlighted how cell-surface molecules govern cellular behavior, intercellular communication, and molecular recognition within the extracellular microenvironment.

Professor Tian presented his team's development of an integrated proteomics sample preparation platform, SISPROT, capable of efficiently processing nanogram-level tissue slices for protein digestion, peptide desalting, and TMT labeling. By combining this technology with multi-color immunohistochemical imaging, proximity labeling, and automated laser capture microdissection, his team achieved high-sensitivity spatial proteomic analysis of formalin-fixed and paraffin-embedded (FFPE) tissues. He further demonstrated the application of these approaches to investigate the tumor microenvironment of pancreatic cancer with high cellular heterogeneity.

The seminar stimulated active discussion and highlighted the growing importance of spatially resolved proteomic technologies in advancing the understanding of complex tissue biology and tumor microenvironments.