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Recent Publications
Wang, T., Sun, W., Fan, L., Hua, C., Wu, N., Fan, S., Zhang, J., Deng, X. & Yan, J. (2021). An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence. eLife, 10: e61885.

doi: 10.7554/eLife.61885
Shao, X., Tan, M., Xie, Y., Yao, C., Wang, T., Huang, H., Zhang, Y., Ding, Y., Liu, J., Han, L., Hua, C., Wang, X. & Deng, X. (2021). Integrated regulatory network in Pseudomonas syringae reveals dynamics of virulence. Cell Reports, 34: 108920.

doi: 10.1016/j.celrep.2021.108920
Kang, T. Z. E., Zhu, L., Yang, D., Ding, D., Zhu, X., Wan, Y. C. E., Liu, J., Ramakrishnan, S., Chan, L. L., Chan, S. Y., Wang, X., Gan, H., Han, J., Ishibashi, T. & Chan, K. M. (2021). The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer. Journal of Biological Chemistry, published online 4 Feb 2021.

doi: 10.1016/j.jbc.2021.100374
Yan, J., Qiu, Y., Ribeiro dos Santos, A.M. et al. (2021). Systematic analysis of binding of transcription factors to noncoding variants. Nature, published online 27 Jan 2021.

doi: 10.1038/s41586-021-03211-0
Zhao, T., Wang, C., Huo, X., He, M.-L. & Chen, J. (2020). Pterostilbene enhances sorafenib’s anticancer effects on gastric adenocarcinoma. Journal of Cellular and Molecular Medicine, 00: 1-12.

doi: 10.1111/jcmm.15795
Fan, L., Wang, T., Hua, C., Sun, W., Li, X., Grunwald, L., Liu, J., Wu, N., Shao, X., Yin, Y., Yan, J. & Deng, X. (2020). A compendium of DNA-binding specificities of transcription factors in Pseudomonas syringae. Nature Communications, 11: 4947.

doi: 10.1038/s41467-020-18744-7
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News

CityU biologists discover super-enhancers that switch on breast cancer genes
15 Apr 2021 CityU biologists discover super-enhancers that switch on breast cancer genes
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a high fatality rate. Currently, chemotherapy is the major treatment option, but the clinical result is unsatisfactory. A research team led by Dr Rebecca Chin and Dr Xin Wang has identified and characterised a set of specific super-enhancers that stimulate the activity of the related critical cancer genes...
CityU wins 6 golds at Inventions Geneva Evaluation Days
24 Mar 2021 CityU wins 6 golds at Inventions Geneva Evaluation Days
Dr Jianbo Yue and Dr Xi Yao received Gold Medals at the Inventions Geneva Evaluation Days (IGED) 2021, a virtual edition of the International Exhibition of Inventions of Geneva...
首創雙幹細胞療法 為心臟修復帶來曙光 First dual stem cell therapy brings new hope for cardiac repair
11 Mar 2021 首創雙幹細胞療法 為心臟修復帶來曙光
First dual stem cell therapy brings new hope for cardiac repair
心肌梗塞簡單來說是冠狀動脈閉塞。因為血流急劇減少或中斷而令部分心肌因嚴重的持久性缺血而壞死。心肌梗塞後，心肌和血管系統都會嚴重受損。城大研發出一種雙管齊下的方法，利用兩種幹細胞同時修復心肌和心臟血管……
Myocardial infarction is caused by blockage in coronary blood vessels. A drastic decrease or suspension of blood supply will lead to permanent damage of the heart muscles. Myocardial infarction causes severe damage to the heart muscles and cardiac vessel system. CityU has developed a dual approach to repair the cardiac muscle and vasculature of the heart...
Microfluidic Technology for Accelerated Screening of Anti-Cancer Drugs
3 Mar 2021 Microfluidic Technology for Accelerated Screening of Anti-Cancer Drugs
New medicines can save and improve lives, but drug discovery is an extremely long and expensive process. Prof. Mengsu (Michael) Yang, one of the top scientists at CityU, is developing an integrated system based on his internationally recognised, award-winning biochip technology, with the aim of providing a novel drug-screening tool with greatly reduced drug development time and cost...
Efficient, Systematic Genetic Analysis Helps Dissect Disease Inheritance
24 Feb 2021 Efficient, Systematic Genetic Analysis Helps Dissect Disease Inheritance
Many genetic variants have been found to have a linkage with genetic diseases, but the understanding of their functional roles in causing diseases are still limited. An international research team, including Dr Jian Yan, has developed a high-throughput biological assay technique which enabled them to conduct a systematic analysis on the impact of nearly 100,000 genetic variants on the binding of transcription factors to DNA...
Regulatory mechanisms of virulence of a plant bacterial pathogen unveiled facilitating the development of new anti-bacterial drugs
3 Dec 2020 Regulatory mechanisms of virulence of a plant bacterial pathogen unveiled facilitating the development of new anti-bacterial drugs
With an increasing global population, we often heard warnings about the possibility of a food supply shortage. In addition to climate change and the reduction of agricultural land, the world's food security is also threatened by bacterial diseases of plants. A joint research team led by Dr Xin Deng and Dr Jian Yan has previously identified a pathogen’s transcription factors, the key proteins that are virulence-related...
CityU excels on global top scientists list
22 Feb 2021 CityU excels on global top scientists list
According to metrics compiled by Stanford University, over 140 CityU faculty members, including Prof. Mengsu (Michael) Yang, are listed among the top 2% of the world's most highly cited scientists, reflecting the high academic standard of our faculty and our excellent research performance...
Health and medical research funding for three Covid-19 projects
12 Jan 2021 Health and medical research funding for three Covid-19 projects
Three projects at City University of Hong Kong (CityU) have been granted $8.3 million in funding by the Health and Medical Research Fund (HMRF) under the Food and Health Bureau, spotlighting our valuable contributions to fighting Covid-19...
ITF funding secured for anti-Covid-19 research
13 Nov 2020 ITF funding secured for anti-Covid-19 research
Research at CityU aimed at tackling Covid-19 has attracted over $7.1 million in funding from the Innovation and Technology Fund (ITF) under the Innovation and Technology Commission. The CityU projects constitute our proactive response to the need for the application of cutting-edge technologies in fighting the epidemic...
What is Long non-coding RNA (lncRNA)?
30 Oct 2020 What is Long non-coding RNA (lncRNA)?
Long non-coding RNA (lncRNA) is a large and diverse class of RNA (ribonucleic acid) molecules which has become a growing focus of cancer genomics studies in recent years. In this article, we will explain what lncRNA is and its functions...
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