CBM Seminar Series - The magic of the genetic duet of BRAF V600E and TERT promoter mutation in thyroid cancer

The College of Biomedicine was pleased to host Professor Mingzhao XING, Chair Professor and the Founding Dean from the School of Medicine, Southern University of Science and Technology, as a distinguished speaker in the CBM Seminar Series on 24 November 2025 (Monday). Professor XING’s research focuses on the aggressive role of the genetic duo BRAF V600E and TERT promoter mutation in papillary thyroid cancer (PTC), prevalent in 6-8% of cases, marking the most severe instances. Research links this duo to higher PTC recurrence and patient mortality, attributing the mechanism to TERT gene activation via BRAF V600E-induced MAP kinase signaling. This genetic interplay boosts TERT levels, fueling oncogenesis and tumor progression, resulting in adverse PTC outcomes. The synergistic oncogenic process not only holds significant clinical implications but also offers promise for genetic-driven precision medicine and therapy in PTC and potentially other cancers.

In his talk, titled “The magic of the genetic duet of BRAF V600E and TERT promoter mutation in thyroid cancer”. Professor XING presented his team on the significant clinical impact of the genetic duet comprising BRAF V600E and TERT promoter mutations in papillary thyroid cancer (PTC). Attendees were treated to a comprehensive exploration of the molecular mechanisms underpinning these mutations and their pivotal role in driving the aggressiveness of PTC.