CBM Seminar Series - Translation of circular RNAs - from regulation mechanisms to therapeutic applications

The College of Biomedicine (CBM) continued its Seminar Series on 20 October 2025, featuring Professor Zefeng Wang, Chair Professor of the Department of System Biology, School of Life Science at the Southern University of Science and Technology. In his talk titled “Translation of Circular RNAs – From Regulation Mechanisms to Therapeutic Applications,” Prof. Wang shared his pioneering research on the emerging role of circular RNAs (circRNAs) in protein translation.

Traditionally viewed as non-coding molecules, circRNAs are now recognized for their ability to undergo cap-independent translation through mechanisms mediated by internal ribosome entry sites (IRES) and m6A modifications. Prof. Wang’s team has uncovered novel insights into these regulatory pathways and demonstrated the therapeutic potential of translatable circRNAs as a new generation of mRNA therapies. His presentation sparked engaging discussions among faculty and students, offering valuable perspectives on the intersection of RNA biology and biomedical innovation.