YANG, Mengsu (Michael)

Prof. YANG, Mengsu (Michael) (楊夢甦)

Yeung Kin Man Chair Professor of Biomedical Sciences

Vice-President (Research & Technology)

Director (BTC)

PhD (Toronto)

Professor Michael Yang Mengsu is currently Vice-President (Research and Technology), Yeung Kin-Man Chair Professor of Biomedical Sciences, and Directors of the Tung Biomedical Sciences Centre. He obtained his BSc degree from Xiamen University in China, MSc degree from Simon Fraser University and PhD degree from the University of Toronto in Canada, and received postdoctoral training in the Scripps Research Institute in the United States of America (USA).

Prof. Yang’s research interests focus on studying cancer biology and developing biochips and nanotechnology for diagnostics and therapeutic applications. He has published over 280 peer-reviewed scientific papers and 33 USA/China patents, delivered research presentations and invited lectures in more than 80 international conferences and 50 universities and academic institutes, and trained more than 40 PhD graduates and 30 postdoctoral fellows. He has co-founded Prenetics and Cellomics, CityU spin-off biotech companies based on technologies developed in his laboratory. Prof. Yang also serves in Hong Kong SAR Government’s Research Grants Council, the Health and Medical Research Fund, the Innovation and Technology Fund, and the Hong Kong Genome Centre. He holds honorary professorships at the Institute of Microsystems of Chinese Academy of Science, Zhejiang University, and Army’s Medical University. He has been awarded the Chunhui Scholar Award by the Ministry of Education in China in 2003, the K. C. Wong Foundation Award in 2004, the Shenzhen Science and Technology Innovation Award in 2006, the Hong Kong Technological Achievement Grand Award in 2007, the Natural Science Award by the Ministry of Education in 2015, and the Wuxi AppTech Life Science and Chemistry Award in 2016.

楊夢甦教授現任香港城市大學(城大)副校長(研究及科技)、楊建文生物醫學系講座教授,以及董氏生物醫學中心主任。他於廈門大學獲得學士學位、加拿大西門菲莎大學獲得碩士學位、多倫多大學獲得博士學位, 再於美國斯克裡普斯研究所完成博士後培訓。

楊教授的研究團隊致力研究腫瘤生物學及開發生物晶片技術和納米技術應用於疾病診斷和治療。他已發表280多篇同行評審科學論文、獲得33項美國及中國專利、應邀在80多個國際會議作學術報告及在50多所大學和科研機構發表演講,並指導了逾40位博士畢業生及30多位博士後研究員,還參與創辦了由城大技術衍生的生物科技公司Prenetics及Cellomics。楊教授是香港特區政府研究資助局、香港醫療衞生研究基金、創新科技基金和香港基因組中心成員,還兼任中國科學院微系統所、浙江大學及陸軍軍醫大學榮譽教授。楊教授曾獲中國教育部「春暉學者獎」(2003年)、王寬誠教育基金會學者獎(2004年)、深圳市創新科技獎(2006年)、香港工商業獎科技成就大獎(2007年)、國家教育部自然科學二等獎(2015年),以及藥明康德生命化學研究獎(2016年)。

Media Publicity

Microfluidic Technology for Accelerated Screening of Anti-Cancer Drugs (CityU Research Story)

楊夢甦:做好癌症最早期的偵察兵 (《今日中國》)

專訪香港城市大學教授楊夢甦:校園創業達人 引領香港生物科技 (藥明康德傳媒)

生物科技與健康 – 從人類基因組到精準醫療 (City Seminar)

Interview with PHARMA Boardroom

楊夢甦:倡社會塑造「創科氛圍」 (《星島日報》)

城大副校長楊夢甦:學生不要害怕失敗 (《星島日報》)

楊夢甦:城大五億培育300初創 (《星島日報》)

Representative Publications

Microfluidics for Cell Analysis

  • Microdissected ‘cuboids’ for microfluidic drug testing of intact tissues, Lab on a Chip, 2021, 21, 122-142.
  • Single cell target gene mutation analysis by arc-edge-channel monolithic valve microfluidic cell isolation and locked nucleic acid based PCR detection, Sensors and Actuators B: Chemical, 2019, 293, 224-234.
  • Recent advances in microfluidic technology for manipulation and analysis of biological cells (2007-2017), Analytica Chimica Acta, 2018, 1044, 29-65.
  • Electrotaxis of cancer stem cells is associated with both activation of stretch-activated cation channels and internal calcium release, Bioelectrochemistry, 2018, 124, 80-92.
  • Cell migration microfluidics for electrotaxis-based heterogeneity study of lung cancer cells, Biosensors and Bioelectronics, 2017, 89, 837-845.
  • Microfluidic platform for studying chemotaxis of adhesive cells revealed a gradient-dependent migration and acceleration of cancer stem cells, Analytical Chemistry, 2015, 87(14), 7098-7108.
  • A microfluidic linear node array for the study of protein-ligand interaction, Lab Chip, 2014, 14, 3993-3999.
  • Single layer linear array of microbeads for multiplexed analysis of DNA and proteins, Biosensors and Bioelectronics, 2014, 54, 297-305.
  • Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells, Lab on a Chip, 2013, 13, 1060-1069.
  • Integrated sieving microstructures on microchannels for biological cell trapping and droplet formation, Lab on a Chip, 2011, 11, 3352-3355.
  • Real-time monitoring of cell-cell communications evoked by mechanical stimulation of suspension cells using an integrated microfluidics chip, Lab on a Chip, 2010, 10, 2271-2278.
  • Microfluidic formation of single cell array for parallel analysis of CRAC channel activation and inhibition, Analytical Biochemistry, 2010, 396, 173-179.
  • A microfluidic device with microbead array for sensitive virus DNA detection and genotyping using quantum dots as fluorescence labels, Biosensors & Bioelectronics, 2010, 25, 2402-2407.
  • 3-D streamline steering by nodes arrayed in an entangled microfluidic network, Lab on a Chip, 2007, 7, 1712-1716.
  • Generation of linear and non-linear concentration gradients along microfluidic channel by microtunnel controlled stepwise addition of sample solution, Lab on a Chip, 2007, 7, 1371-1373.
  • Dose-dependent cell-based assays in V-shaped microfluidic channels, Lab on a Chip, 2006, 6, 921-929.
  • Microfluidics technology for manipulation and analysis of biological cells, Analytica Chimica Acta, 2006, 560, 1-23.
  • Hydrodynamic simulation of cell docking in microfluidic channels with different dam structures, Lab on a Chip, 2004, 4, 53–59.
  • Cell docking and on-chip monitoring of cellular reactions under controlled concentration gradient on a microfluidic device, Analytical Chemistry, 2002, 74, 3991-4001.
  • Generation of concentration gradient by diffusive mixing and consecutive dilution in a microfluidic chip, Lab on a Chip, 2002, 2, 158-163.

Cancer Biology & Nanomedicine

  • Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance, Nanomedicine. 2021, 16, 1411–1427.
  • Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ, Oncogene, 2021, 40, 1775–1791.
  • Magnetothermal miniature reactors based on iron oxide nanocubes-coated liquid marbles, Advanced Healthcare Materials, 2021, 2001658 (8 pages).
  • Single-cell EMT-related transcriptional analysis uncovers the intra-cluster heterogeneity of tumor cell clusters in epithelial ovarian cancer ascites, Oncogene, 2020, 39(21), 4227–4240.
  • Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy, Theranostics, 2020, 10(3), 1181-1196.
  • Recent Progress of Ferroptosis Inducers for Cancer Therapy, Advanced Materials, 2019, 1904197, pp25.
  • Efficient RNA drug delivery using red blood cell extracellular vesicles, Nature Communications, 2018, 9(1), 2359 (15 pages).
  • Transparent and gas-permeable liquid marbles for culturing and drug sensitivity test of tumor spheroids, Advanced Healthcare Materials, 2017, 1700185.
  • Chemoresistant lung cancer stem cells display high DNA repair capability to remove cisplatin-DNA damage, British Journal of Pharmacology, 2017, 174(4), 302-313.
  • Activation of multiple signaling pathways during the differentiation of mesenchymal stem cells cultured in silicon nanowire microenvironment, Nanomedicine: Nanotechnology, Biology, and Medicine, 2014, 10(6), 1153-63.
  • Reorganization of cytoskeleton and transient activation of Ca2+ channels in mesenchymal stem cells cultured on silicon nanowire arrays, ACS Applied Materials & Interfaces, 2013, 5, 13295−13304.
  • Multienzyme-nanoparticles amplification for sensitive virus genotyping in microfluidic microbeads array using Au nanoparticle probes and quantum dots as labels, Biosensors and Bioelectronics, 2011, 29, 89-96.
  • Gold nanoparticles promote osteogenic differentiation of mesenchymal stem cells, ACS Nano, 2010, 4, 6439-6448.
  • Inhibition of proliferation and differentiation of mesenchymal stem cells by carboxylated carbon nanotubes, ACS Nano, 2010, 4(4), pp 2185–2195.
  • COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis, Clinical Cancer Research, 2008, 14 (16), 5061-5068.
  • DNA-directed self-assembly of gold nanoparticles into binary and ternary nanostructures, Nanotechnology, 2007, 18, 015102 (7 pages).
  • Hypoxia induces the activation of human hepatic stellate cells LX-2 activation through TGF-b signaling pathway, FEBS Letters, 2007, 581, 203-210.
  • Clustin plays an important role in hepatocellular carcinoma metastasis, Oncogene, 2006, 25, 1242-1250.
  • Molecular mechanisms of survival and apoptosis in RAW 264.7 macrophages under oxidative stress, Apoptosis, 2005, 10, 545-556.
  • Association of overexpression of vimentin and hepatocellular carcinoma metastasis. Oncogene, 2004, 23, 298-302.

11 February 2022

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