Representa­tive Publications

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“Heat-Press-N-Go” Stretchable Interconnects Enabled by Liquid Metal Conductor with Supramolecular Confinement

L. Ai, W. Lin, L. Ai, Y. Li, M. Qiang, X. Wang, M. Shi, Z. Yang, X. Yao* (2025). “Heat-Press-N-Go” Stretchable Interconnects Enabled by Liquid Metal Conductor with Supramolecular Confinement. Advanced Functional Materials, 35(20), 2425264.
doi: 10.1002/adfm.202425264

Highly Stable Liquid Metal-Based Electronic Textiles by Adaptive Interfacial Interactions

C. Cao, H. Su, L. Ai, D. Lv, J. Gu, R. Li, D. Li, W. Zhang, M. Ge*, X. Yao* (2024). Highly Stable Liquid Metal-Based Electronic Textiles by Adaptive Interfacial Interactions. Advanced Functional Materials, 34(49), 2409586.
doi: 10.1002/adfm.202409586

Inducing Immunogenic Cancer Cell Death through Oxygen-Economized Photodynamic Therapy with Nitric Oxide-Releasing Photosensitizers

F. Xu, M. Wang, E. Dotse, K. T. Chow*, P.-C. Lo* (2024). Inducing Immunogenic Cancer Cell Death through Oxygen-Economized Photodynamic Therapy with Nitric Oxide-Releasing Photosensitizers. Angewandte Chemie International Edition, 63(37), e202404561.
doi: 10.1002/anie.202404561

Biophysical and Biochemical Roles of Shear Stress on Endothelium: A Revisit and New Insights

C. K. Cheng, N. Wang, L. Wang*, Y. Huang* (2025). Biophysical and Biochemical Roles of Shear Stress on Endothelium: A Revisit and New Insights. Circulation Research, 136(7), 752–772.
doi: 10.1161/CIRCRESAHA.124.325685

Endothelial Serotonin Receptor 1B Acts as a Mechanosensor to Drive Atherosclerosis

M. Jiang, H. Ding, Y. Huang, C. W. Lau, Y. Guo, J. Luo, Y.-T. Shih, Y. Xia, X. Yao, J.-J. Chiu, L. Wang, S. Chien, Y. Huang* (2025). Endothelial Serotonin Receptor 1B Acts as a Mechanosensor to Drive Atherosclerosis. Circulation Research, 136(8), 887–901.
doi: 10.1161/CIRCRESAHA.124.325453

Daily oral administration of probiotics engineered to constantly secrete short-chain fatty acids effectively prevents myocardial injury from subsequent ischaemic heart disease

Q. H. Pham, T. V. A. Bui, W.-S. Sim, K. H. Lim, C. O. K. Law, W. Tan, R. Y. Kim, K. T. Chow*, H.-J. Park*, K. Ban*, T. C. K. Lau* (2024). Daily oral administration of probiotics engineered to constantly secrete short-chain fatty acids effectively prevents myocardial injury from subsequent ischaemic heart disease. Cardiovascular Research, 120(14), 1737–1751.
doi: 10.1093/cvr/cvae128

Strong and high-conductivity hydrogels with all-polymer nanofibrous networks for applications as high-capacitance flexible electrodes

H. He, Y. Chen, A. Pu, L. Wang, W. Li, X. Zhou, C. Y. Tang, K. Ban, M. Yang*, L. Xu* (2024). Strong and high-conductivity hydrogels with all-polymer nanofibrous networks for applications as high-capacitance flexible electrodes. npj Flexible Electronics, 8, 56.
doi: 10.1038/s41528-024-00346-8

Comprehensive comparison of the third-generation sequencing tools for bacterial 6mA profiling

B. Lu, Z. Guo, X. Liu, Y. Ni, L. Xu, J. Huang, T. Li, T. Feng, R. Li*, X. Deng* (2025). Comprehensive comparison of the third-generation sequencing tools for bacterial 6mA profiling. Nature Communications, 16, 59187.
doi: 10.1038/s41467-025-59187-2

Stress-eliminated liquid-phase fabrication of colloidal films above the critical crack thickness

S. Liu, Y. Hong, W. Hong, Y. Zheng, X. Yang, X. Li, Z. Zhang, X. Yan, Y. Shan, W. Lin, Z. Peng, X. Zhang, X. Yao*, Z. Wang*, Z. Yang* (2024). Stress-eliminated liquid-phase fabrication of colloidal films above the critical crack thickness. Nature Communications, 15, 10136.
doi: 10.1038/s41467-024-54412-w

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β-TrCP-Mediated IFNAR1 Degradation

Q. Wan, L. Zhu, C. Chen, L. Zhong, H. Leung, W. Li, C. Xu, X. Yao, H. Hu, M. Wu, Y. Hou, H. Chu, Y. Wang, S. Chen, M. Pan*, Z. Cai*, M.-L. He* (2025). PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β-TrCP-Mediated IFNAR1 Degradation. Advanced Science, e03487.
doi: 10.1002/advs.202503487

GLS1-Mediated Redundancy in Glutamate Accelerates Arterial Calcification via Activating NMDAR/Ca2+/β-Catenin Pathway

Z. Zhou, B. Dong, D. He, J. Ma, Y. Kong, H. Zhu, C. Xie, T. Yang, X. Zhen, Z. Zhang, Z. He, J. Cheng, A. Huang, J. Chen, R. Wu, H. Yin*, Y. Chen*, J. Tao*, H. Huang* (2025). GLS1-Mediated Redundancy in Glutamate Accelerates Arterial Calcification via Activating NMDAR/Ca2+/β-Catenin Pathway. Advanced Science, 12(21), 2414252.
doi: 10.1002/advs.202414252

Extracellular Vesicle Preparation and Analysis: A State-of-the-Art Review

Z. Wang, X. Zhou, Q. Kong, H. He, J. Sun, W. Qiu, L. Zhang, M. Yang* (2024). Extracellular Vesicle Preparation and Analysis: A State-of-the-Art Review. Advanced Science, 11(30), 2401069.
doi: 10.1002/advs.202401069

VimR is a conserved master transcription regulator controlling virulence and metabolism in Pseudomonas

F. Chen, Y. Sun, J. Huang, T. Li, B. Lu, Z. He, J. Li, T. Wang, H. Hu, X. Deng* (2025). VimR is a conserved master transcription regulator controlling virulence and metabolism in Pseudomonas. Nucleic Acids Research, 53(11), gkaf493.
doi: 10.1093/nar/gkaf493

Targeting TUBB2B inhibits triple-negative breast cancer growth and brain-metastatic colonization

Q. He, J. Hu, F.-Y. Ngo, H. Zhang, L. He, H. Huang, T. Wu, Y. Pan, Z. Yang, Y. Jiang, W. C. Cho, W. Cheuk, G. M. Tse, J. Y. Tsang, M. Yang, L. Zhang, X. Wang, P.-C. Lo, G. Lau, Y. R. Chin* (2025). Targeting TUBB2B inhibits triple-negative breast cancer growth and brain-metastatic colonization. Journal of Experimental and Clinical Cancer Research, 44, 55.
doi: 10.1186/s13046-025-03312-y

Environmental pollution to kidney disease: an updated review of current knowledge and future directions

X. Q. Lao*, Y. Bo, D. Chen, K. Zhang, C.-C. Szeto (2024). Environmental pollution to kidney disease: an updated review of current knowledge and future directions. Kidney International, 106(2), 214–225.
doi: 10.1016/j.kint.2024.04.021

Harnessing intracellular bacteria in bladder by intravesical delivery of antibiotics-loaded nanodiamonds to reduce the recurrence of urinary tract infection

C. O. K. Law, H. M. Leung, M. Wang, Q. Nie, Q. H. Pham, K. C. Han, T. S. Wong, K. T. Chow*, P. K. Lo, T. C. K. Lau* (2025). Harnessing intracellular bacteria in bladder by intravesical delivery of antibiotics-loaded nanodiamonds to reduce the recurrence of urinary tract infection. Journal of Nanobiotechnology, 23, 367.
doi: 10.1186/s12951-025-03459-y

Dynamic silicone hydrogel gauze coatings with dual anti-blood adhesion mechanism for rapid hemostasis and minimal secondary damage

X. Xu, Y. Chen, Y. Li, X. Li, J. Bai, X. Jiang, D. Yu, X. Wu*, X. Yao* (2024). Dynamic silicone hydrogel gauze coatings with dual anti-blood adhesion mechanism for rapid hemostasis and minimal secondary damage. Science Advances, 10(49), eado4944.
doi: 10.1126/sciadv.ado4944

Chrom-seq identifies RNAs at chromatin marks

L. Fan, W. Sun, Y. Lyu, F. Ju, W. Sun, J. Chen, H. Ma, S. Yang, X. Zhou, N. Wu, W. Yi, E. Chen, R. Villaseñor, T. Baubec, J. Yan* (2024). Chrom-seq identifies RNAs at chromatin marks. Science Advances, 10(31), eadn1397.
doi: 10.1126/sciadv.adn1397

Activation of Nrf2 inhibits atherosclerosis in ApoE−/− mice through suppressing endothelial cell inflammation and lipid peroxidation

L. He, Q. Chen, L. Wang, Y. Pu, J. Huang, C. K. Cheng, J.-Y. Luo, L. Kang, X. Lin, L. Xiang, L. Fang, B. He, Y. Xia, K. O. Lui, Y. Pan, J. Liu, C.-L. Zhang*, Y. Huang* (2024). Activation of Nrf2 inhibits atherosclerosis in ApoE−/− mice through suppressing endothelial cell inflammation and lipid peroxidation. Redox Biology, 74, 103229.
doi: 10.1016/j.redox.2024.103229

Targeting WDPF domain of Hsp27 achieves a broad spectrum of antiviral

M. Wu, W. Li, H. Leung, Y. Wang, Q. Wan, P. Chen, C. Chen, Y. Li, X. Yao*, M.-L. He* (2025). Targeting WDPF domain of Hsp27 achieves a broad spectrum of antiviral. MedComm, 6(3), e70032.
doi: 10.1002/mco2.70032

Monitoring hepatocellular carcinoma using tumor content in circulating cell-free DNA

S. Lian, C. Lu, F. Li, X. Yu, L. Ai, B. Wu, X. Gong, W. Zhou, X. Liang, J. Zhan, Y. Yuan, F. Fang, Z. Liu*, M. Ji*, Z. Zheng* (2024). Monitoring hepatocellular carcinoma using tumor content in circulating cell-free DNA. Clinical Cancer Research, 30(13), 2772–2779.
doi: 10.1158/1078-0432.CCR-23-3449

Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity

H. Li, X. Wang, Y. Wang, Y. Li, Y. Chen, Y.-T. Wong, J. He, M.-L. He* (2023). Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity. Signal Transduction and Targeted Therapy, 8, 374.
doi: 10.1038/s41392-023-01630-1

SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis

C. K. Cheng, X. Lin, Y. Pu, J. K. Y. Tse, Y. Wang, C.-L. Zhang, X. Cao, C. W. Lau, J. Huang, L. He, J.-Y. Luo, Y.-T. Shih, S. Wan, C. F. Ng, L. Wang, R. C. W. Ma, J.-J. Chiu, T. F. Chan, X. Y. Tian*, Y. Huang* (2023). SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis. Journal of Advanced Research, 43, 187–203.
doi: 10.1016/j.jare.2022.02.017

Endothelial UCP2 Is a Mechanosensitive Suppressor of Atherosclerosis

J.-Y. Luo*, C. K. Cheng, L. He, Y. Pu, Y. Zhang, X. Lin, A. Xu, C. W. Lau, X. Y. Tian, R. C. W. Ma, H. Jo, Y. Huang* (2022). Endothelial UCP2 Is a Mechanosensitive Suppressor of Atherosclerosis. Circulation Research, 131(5), 424–441.
doi: 10.1161/CIRCRESAHA.122.321187

Branched-chain amino acid supplementation impairs insulin sensitivity and promotes lipogenesis during exercise in diet-induced obese mice

H. Zhang, L. Xiang, M. Huo, Y. Wu, M. Yu, C. W. Lau, D. Tian, L. Gou, Y. Huang, J.-Y. Luo, L. Wang, W. Song, J. Huang, Z. Cai, S. Chen*, X. Y. Tian*, Y. Huang* (2022). Branched-chain amino acid supplementation impairs insulin sensitivity and promotes lipogenesis during exercise in diet-induced obese mice. Obesity (Silver Spring), 30, 1205–1218.
doi: 10.1002/oby.23394

Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization

L. Zhao, C.-L. Zhang*, L. He, Q. Chen, L. Liu, L. Kang, J. Liu, J.-Y. Luo, L. Gou, D. Qu, W. Song, C. W. Lau, H. Ko, V. C. T. Mok, X. Y. Tian, L. Wang, Y. Huang* (2022). Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Lowering Mitochondrial ROS-Mediated eNOS Monomerization. Diabetes, 71(5), 1099–1114.
doi: 10.2337/db21-0660

High Throughput Confined Migration Microfluidic Device for Drug Screening

Z. Yang, Z. Zhou, T. Si, Z. Zhou, L. Zhou, Y. R. Chin, L. Zhang, X. Guan, M. Yang* (2023). High Throughput Confined Migration Microfluidic Device for Drug Screening. Small, 19, 2207194.
doi: 10.1002/smll.202207194

Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network

Z. Yang, L. Zhou, T. Si, S. Chen, C. Liu, K. K. Ng, Z. Wang, Z. Chen, C. Qiu, G. Liu, Q. Wang, X. Zhou, L. Zhang, Z. Yao, S. He, M. Yang*, Z. Zhou* (2023). Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network. Molecular Cancer, 22, 21.
doi: 10.1186/s12943-023-01727-9

Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner

Z. Deng, H. Li, S. Chen, N. Wang, G. Liu, D. Liu, W. Ou, F. Xu, X. Wang, D. Lei, P.-C. Lo, Y. Y. Li, J. Lu, M. Yang, M.-L. He*, G. Zhu* (2023). Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner. Nature Chemistry, 15, 930–939.
doi: 10.1038/s41557-023-01242-w

Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection

P. Chen, M. Wu, Y. He, B. Jiang, M.-L. He* (2023). Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection. Signal Transduction and Targeted Therapy, 8, 237.
doi: 10.1038/s41392-023-01510-8

Continuous Energy Harvesting from Ubiquitous Humidity Gradients using Liquid-Infused Nanofluidics

S. Zheng*, J. Tang, D. Lv, M. Wang, X. Yang, C. Hou, B. Yi, G. Lu, R. Hao, M. Wang, Y. Wang*, H. He, X. Yao* (2022). Continuous Energy Harvesting from Ubiquitous Humidity Gradients using Liquid-Infused Nanofluidics. Advanced Materials, 34, 2106410.
doi: 10.1002/adma.202106410

Wetting ridge assisted programmed magnetic actuation of droplets on ferrofluid-infused surface

J. Zhang, X. Wang, Z. Wang, S. Pan, B. Yi, L. Ai, J. Gao*, F. Mugele*, X. Yao* (2021). Wetting ridge assisted programmed magnetic actuation of droplets on ferrofluid-infused surface. Nature Communications, 12, 7136.
doi: 10.1038/s41467-021-27503-1

The role of aldehyde dehydrogenase 2 in cardiovascular disease

J. Zhang, Y. Guo, X. Zhao, J. Pang, C. Pan, J. Wang, S. Wei, X. Yu, C. Zhang, Y. Chen*, H. Yin*, F. Xu* (2023). The role of aldehyde dehydrogenase 2 in cardiovascular disease. Nature Reviews Cardiology, 20, 495–509.
doi: 10.1038/s41569-023-00839-5

Enzyme-Responsive Double-Locked Photodynamic Molecular Beacon for Targeted Photodynamic Anticancer Therapy

L. K. B. Tam, J. C. H. Chu, L. He, C. Yang, K.-C. Han, P. C. K. Cheung, D. K. P. Ng, P.-C. Lo (2023). Enzyme-Responsive Double-Locked Photodynamic Molecular Beacon for Targeted Photodynamic Anticancer Therapy. Journal of the American Chemical Society, 145(13), 7361–7375.
doi: 10.1021/jacs.2c13732

Mutation-independent gene knock-in therapy targeting 5′UTR for autosomal dominant retinitis pigmentosa

D. A. Hoang, B. Liao, Z. Zheng, W. Xiong* (2023). Mutation-independent gene knock-in therapy targeting 5′UTR for autosomal dominant retinitis pigmentosa. Signal Transduction and Targeted Therapy, 8, 100.
doi: 10.1038/s41392-022-01308-0

The impact of contact tracing and testing on controlling COVID-19 outbreak without lockdown in Hong Kong: An observational study

H.-Y. Yuan*, C. Blakemore (2022). The impact of contact tracing and testing on controlling COVID-19 outbreak without lockdown in Hong Kong: An observational study. The Lancet Regional Health – Western Pacific, 20, 100374.
doi: 10.1016/j.lanwpc.2021.100374

The impact of multiple non-pharmaceutical interventions on controlling COVID-19 outbreak without lockdown in Hong Kong: A modelling study

H.-Y. Yuan*, C. Blakemore (2022). The impact of multiple non-pharmaceutical interventions on controlling COVID-19 outbreak without lockdown in Hong Kong: A modelling study. The Lancet Regional Health – Western Pacific, 20, 100343.
doi: 10.1016/j.lanwpc.2021.100343

Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes

D. Yuan, Y. Zhang, K. H. Lim, S. K. P. Leung, X. Yang, Y. Liang, W. C. Y. Lau, K. T. Chow*, J. Xia* (2022). Site-Selective Lysine Acetylation of Human Immunoglobulin G for Immunoliposomes and Bispecific Antibody Complexes. Journal of the American Chemical Society, 144(40), 18494–18503.
doi: 10.1021/jacs.2c07594

An atlas of bacterial two-component systems reveals function and plasticity in signal transduction

Y. Xie, J. Li, Y. Ding, X. Shao, Y. Sun, F. Xie, S. Liu, S. Tang, X. Deng (2022). An atlas of bacterial two-component systems reveals function and plasticity in signal transduction. Cell Reports, 41(3), 111502.
doi: 10.1016/j.celrep.2022.111502

Single-cell RNA-seq recognized the initiator of epithelial ovarian cancer recurrence

T. Kan, S. Zhang, S. Zhou, Y. Zhang, Y. Zhao, Y. Gao, T. Zhang, F. Gao, X. Wang, L. Zhao, M. Yang (2022). Single-cell RNA-seq recognized the initiator of epithelial ovarian cancer recurrence. Oncogene, 41, 895–906.
doi: 10.1038/s41388-021-02139-z

Defect-enhanced selective ion transport in an ionic nanocomposite for efficient energy harvesting from moisture

D. Lv, S. Zheng, C. Cao, K. Li, L. Ai, X. Li, Z. Yang, Z. Xu, X. Yao (2022). Defect-enhanced selective ion transport in an ionic nanocomposite for efficient energy harvesting from moisture. Energy & Environmental Science, 15, 2601–2609.
doi: 10.1039/D2EE00432A

Lung adenocarcinoma-related target gene prediction and drug repositioning

R. X. Huang, D. Siriwanna, W. C. Cho, T. K. Wan, Y. R. Du, A. N. Bennett, Q. E. He, J. D. Liu, X. T. Huang, K. H. K. Chan (2022). Lung adenocarcinoma-related target gene prediction and drug repositioning. Frontiers in Pharmacology, 13, 936758.
doi: 10.3389/fphar.2022.936758

Wetting ridge assisted programmed magnetic actuation of droplets on ferrofluid-infused surface

J. Zhang, X. Wang, Z. Wang, S. Pan, B. Yi, L. Ai, J. Gao, F. Mugele, X. Yao (2021). Wetting ridge assisted programmed magnetic actuation of droplets on ferrofluid-infused surface. Nature Communications, 12, 7136.
doi: 10.1038/s41467-021-27503-1

Attenuating innate immunity and facilitating β-coronavirus infection by NSP1 of SARS-CoV-2 through specific redistributing hnRNP A2/B1 cellular localization

F. Zhou, Q. Wan, S. Chen, Y. Chen, P.-H. Wang, X. Yao, M.-L. He (2021). Attenuating innate immunity and facilitating β-coronavirus infection by NSP1 of SARS-CoV-2 through specific redistributing hnRNP A2/B1 cellular localization. Signal Transduction and Targeted Therapy, 6, 371.
doi: 10.1038/s41392-021-00786-y

Deep RNA Sequencing Revealed Fusion Junctional Heterogeneity May Predict Crizotinib Treatment Efficacy in ALK-Rearranged NSCLC

Z. Song, S. Lian, S. Mak, M. Z.-Y. Chow, C. Xu, W. Wang, H. Y. Keung, C. Lu, F. T. Kebede, Y. Gao, W. Cheuk, W. C. S. Cho, M. Yang, Z. Zheng* (2021). Deep RNA Sequencing Revealed Fusion Junctional Heterogeneity May Predict Crizotinib Treatment Efficacy in ALK-Rearranged NSCLC. Journal of Thoracic Oncology, 17(2), 264–176.
doi: 10.1016/j.jtho.2021.09.016

Pseudomonas syringae senses polyphenols via phosphorelay crosstalk to inhibit virulence

Y. Xie, Y. Ding, X. Shao, C. Yao, J. Li, J. Liu, X. Deng* (2021). Pseudomonas syringae senses polyphenols via phosphorelay crosstalk to inhibit virulence. EMBO Reports, 22, e52805.
doi: 10.15252/embr.202152805

Self-adaptive and efficient propulsion of Ray sperms at different viscosities enabled by heterogeneous dual helixes

P. Wang, M. A. R. Al Azad, X. Yang, P. R. Martelli, K. Y. Cheung, J. Shi*, Y. Shen* (2021). Self-adaptive and efficient propulsion of Ray sperms at different viscosities enabled by heterogeneous dual helixes. PNAS, 118(23), e2024329118.
doi: 10.1073/pnas.2024329118

Bioinspired Supramolecular Slippery Organogels for Controlling Pathogen Spread by Respiratory Droplets

Z. Wang, B. Yi, M. Wu, D. Lv, M.-L. He*, M. Liu*, X. Yao* (2021). Bioinspired Supramolecular Slippery Organogels for Controlling Pathogen Spread by Respiratory Droplets. Advanced Functional Materials, 31, 2102888.
doi: 10.1002/adfm.202102888

PIM1 kinase facilitates Zika virus replication by suppressing host cells’ natural immunity

F. Zhou, Q. Wan, Y. Chen, S. Chen, M.-L. He* (2021). PIM1 kinase facilitates Zika virus replication by suppressing host cells’ natural immunity. Signal Transduction and Targeted Therapy, 6(1), 207.
doi: 10.1038/s41392-021-00539-x

Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2

L. Huang, T. Yuen, Z. Ye, S. Liu, G. Zhang, H. Chu*, J. Yue* (2021). Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2. Signal Transduction and Targeted Therapy, 6, 168.
doi: 10.1038/s41392-021-00584-6

OCaMIR—A Noninvasive, Diagnostic Signature for Early-Stage Ovarian Cancer: A Multi-cohort Retrospective and Prospective Study

R. Kandimalla, W. Wang, F. Yu, N. Zhou, F. Gao, M. Spillman, L. Moukova, O. Slaby, B. Salhia, S. Zhou*, X. Wang*, A. Goel* (2021). OCaMIR—A Noninvasive, Diagnostic Signature for Early-Stage Ovarian Cancer: A Multi-cohort Retrospective and Prospective Study. Clinical Cancer Research, 27(15), 4277–4286.
doi: 10.1158/1078-0432.CCR-21-0267

Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ

Z. Ye, D. Wang, Y. He, J. Yu, W. Wei, C. Chen, R. Wang, L. Zhang, L. H. Zhang, L. R. Zhang, M. Le, W. Cho, M. Yang, H. Zhang, J. Yue* (2021). Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ. Oncogene, 40, 1775–1791.
doi: 10.1038/s41388-021-01662-3

Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling

H. Huang, J. Hu, M. A. Maryam, Q. Huang, Y. Zhang, S. Ramakrishnan, J. Li, H. Ma, V. W. Ma, W. Cheuk, G. Y. K. So, W. Wang, W. C. S. Cho, L. Zhang, M. Chan, X. Wang*, Y. R. Chin* (2021). Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling. Nature Communications, 12, 2242.
doi: 10.1038/s41467-021-22445-0

Systematic analysis of binding of transcription factors to noncoding variants

J. Yan*, Y. Qiu, A. M. Ribeiro Dos Santos, Y. Yin, Y. E. Li, N. Vinckier, N. Nariai, P. Benaglio, A. Raman, X. Li, S. Fan, J. Chiou, F. Chen, K. A. Frazer, K. J. Gaulton, M. Sander, J. Taipale*, B. Ren* (2021). Systematic analysis of binding of transcription factors to noncoding variants. Nature, 591, 147–151.
doi: 10.1038/s41586-021-03211-0

Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery

T. C. Pham, M. K. Jayasinghe, T. T. Pham, Y. Yang, L. Wei, W. M. Usman, H. Chen, M. Pirisinu, J. Gong, S. Kim, B. Peng, W. Wang, C. Chan, V. Ma, N. T. H. Nguyen, D. Kappei, X. H. Nguyen, W. C. Cho, J. Shi*, M. T. N. Le* (2021). Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery. Journal of Extracellular Vesicles, 10(4), e12057.
doi: 10.1002/jev2.12057

Integrated regulatory network in Pseudomonas syringae reveals dynamics of virulence

X. Shao, M. Tan, Y. Xie, C. Yao, T. Wang, H. Huang, Y. Zhang, Y. Ding, J. Liu, L. Han, C. Hua, X. Wang*, X. Deng* (2021). Integrated regulatory network in Pseudomonas syringae reveals dynamics of virulence. Cell Reports, 34(13), 108920.
doi: 10.1016/j.celrep.2021.108920

An integrated workflow for biomarker development using microRNAs in extracellular vesicles for cancer precision medicine

Y. Chen, T. Wu, Z. Zhu, H. Huang, L. Zhang, A. Goel, M. Yang, X. Wang* (2021). An integrated workflow for biomarker development using microRNAs in extracellular vesicles for cancer precision medicine. Seminars in Cancer Biology, 74, 134–155.
doi: 10.1016/j.semcancer.2021.03.011

An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

T. Wang, W. Sun, L. Fan, C. Hua, N. Wu, S. Fan, J. Zhang, X. Deng*, J. Yan* (2021). An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence. eLife, 10, e61885.
doi: 10.7554/eLife.61885

Profiling MicroRNAs with Associated Spatial Dynamics in Acute Tissue Slices

K. Xie, Z. Wang, L. Qi, X. Zhao, Y. Wang, J. Qu, L. Huang, W. Zhang, Y. Yang*, X. Wang*, P. Shi* (2021). Profiling MicroRNAs with Associated Spatial Dynamics in Acute Tissue Slices. ACS Nano, 15(3), 1936–0851.
doi: 10.1021/acsnano.0c09676

Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors

Y. Li, P. Sun, L. Zhao, X. Yan*, D. K. P. Ng*, P. C. Lo* (2020). Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors. Angewandte Chemie International Edition, 59(51), 23228–23238.
doi: 10.1002/anie.202010005

CRISPR-assisted detection of RNA–protein interactions in living cells

Y. Yi, J. Li, X. Zhu, X. Wang, L. Fan, W. Sun, L. Liao, J. Zhang, X. Li, J. Ye, F. Chen, J. Taipale, K. M. Chan*, L. Zhang*, J. Yan* (2020). CRISPR-assisted detection of RNA–protein interactions in living cells. Nature Methods, 17(7), 685–688.
doi: 10.1038/s41592-020-0866-0

A compendium of DNA-binding specificities of transcription factors in Pseudomonas syringae

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