Professor Sheng CHEN

Professor of Veterinary Bacteriology
Associate Dean (Research), Jockey Club College of Veterinary Medicine and Life Sciences (JCC)
Office Address
Room 1B-407, 4/F, Block 1, To Yuen Building, 31 To Yuen Street, City University of Hong Kong
Office Tel

Prof. Chen received his veterinary degree in 1997 and a Master of Preventive Veterinary Medicine degree in 2000, both from the China Agriculture University. He completed his PhD in Food Microbiology at the University of Maryland, USA, in 2004, and his postdoctoral training in the Department of Microbiology and Molecular Genetics at the Medical College of Wisconsin, USA, in 2009. Before joining City University of Hong Kong in 2019, he had spent 10 years working in the Department of Applied Biology and Chemical Technology at the Hong Kong Polytechnic University as Assistant Professor, Associate Professor and Professor.

Prof. Chen participates in the Hong Kong government’s policy making through an ad-hoc working group on microbial guidelines for ready-to-eat food under the Department of Food and Environmental Hygiene of Hong Kong Government. He is also a member of the Shenzhen Expert Committee to help the Shenzhen government’s decision making on the development of biotechnologies. He has established and served as the Director of the Shenzhen Key Laboratory for Food Biological Safety Control before joining CityU.

Prof. Chen’s current research covers research on bacterial antimicrobial resistance, virulence and tolerance in the veterinary, food and medical microbiology fields. His research lies on the interface of clinical study and basic science using multi-disciplinary approaches including Genomics, Genetics, Biochemistry, Cell Biology and Chemical Biology with the ultimate goal of developing novel therapies to combat bacterial antimicrobial resistance.

Selected from a total of 189 publications by October 2020.

Zhang R, Dong N, Shen ZQ, Zeng Y, Lu JY, Liu CC, Zhou HW, Hu YY, Sun QL, Cheng QP, Shu LB, Cai JC, Chan EWC, Chen GX, Chen S*.
Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X).
Nature Communications. Nat Commun. 2020 Sep 16;11(1):4648. DOI: 10.1038/s41467-020-18475-9

Sun, Z., Shang, Z., Forelli, N., Po, K. H. L., Chen, S., Brady, S. F. & Li, X.
Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation Mediated Cyclization and Absolute Structure Establishment. 29 Jul 2020.
Angewandte Chemie-International Edition. DOI: 10.1002/anie.202009092 (IF=12.96)

Yang, X., Dong, N., Chan, E. W., Zhang, R. & Chen, S*.
Carbapenem Resistance-Encoding and Virulence-Encoding Conjugative Plasmids in Klebsiella pneumoniae. 21 May 2020
Trends in Microbiology. Trends Microbiol. 2020 May 21:S0966-842X(20)30105-0. DOI: 10.1016/j.tim.2020.04.012

Qiu, J., Nie, Y., Zhao, Y., Zhang, Y., Li, L., Wang, R., Wang, M., Chen, S., Wang, J., Li, Y. & Xia, J.
Safeguarding intestine cells against enteropathogenic Escherichia coli by intracellular protein reaction, a preventive antibacterial mechanism. 10 Mar 2020
Proceedings of the National Academy of Sciences of the United States of America. 2020 Mar 10;117(10):5260-5268. DOI: 10.1073/pnas.1914567117

Yang X, Ye L, Chan EW, Zhang R, Chen S*.
Tracking Recombination Events That Occur in Conjugative Virulence Plasmid p15WZ-82_Vir during the Transmission Process.
mSystems. 2020 Jul 14;5(4):e00140-20. DOI: 10.1128/mSystems.00140-20

Pan Y, Zeng J, Li L, Yang J, Tang Z, Xiong W, Li Y, Chen S*, Zeng Z.
Coexistence of Antibiotic Resistance Genes and Virulence Factors Deciphered by Large-Scale Complete Genome Analysis.
mSystems. 2020 Jun 2;5(3):e00821-19. DOI: 10.1128/mSystems.00821-19

Chow HY, Po KHL, Gao P, Blasco P, Wang X, Li C, Ye L, Jin K, Chen K, Chan EWC, You X, Yi Tsun Kao R, Chen S*, Li X.
Methylation of Daptomycin Leading to the Discovery of Kynomycin, a Cyclic Lipodepsipeptide Active against Resistant Pathogens.
J Med Chem. 2020 Mar 26;63(6):3161-3171. DOI: 10.1021/acs.jmedchem.9b01957. Epub 2020 Mar 10.

Xu, C., Chen, K., Chan, K. F., Chan, E. W. C., Guo, X., Chow, H. Y., Zhao, G., Zeng, P., Wang, M., Zhu, Y., Li, X., Wong, K-Y. & Chen, S*.
Imidazole Type Antifungal Drugs Are Effective Colistin Adjuvants That Resensitize Colistin-Resistant Enterobacteriaceae. 22 Jun 2020
Advanced Therapeutics. UNSP 2000084.

Yang XM, Chan, EWC, Zhang R, Chen, S*. .
A conjugative plasmid that augments virulence in Klebsiella pneumoniae.
Nature Microbiology. 2019, September. DOI: 10.1038/s41564-019-0566-7
Also a Nature 'Research Highlight in Public Health': Bacteria that plague hospital patients gain a potent weapon

Chen K, Dong N, Chan EW, Chen S*.
Transmission of ciprofloxacin resistance in Salmonella mediated by a novel type of conjugative helper plasmids.
Emerg Microbes Infect. 2019;8(1):857-865. DOI: 10.1080/22221751.2019.1626197

Liu X, Geng S, Chan EW, Chen S*.
Increased prevalence of Escherichia coli strains from food carrying bla NDM and mcr-1-bearing plasmids that structurally resemble those of clinical strains, China, 2015 to 2017.
Euro Surveill. 2019 Mar;24(13). DOI: 10.2807/1560-7917.ES.2019.24.13.1800113

Chen K, Chan EWC, Chen S*.
Evolution and transmission of a conjugative plasmid encoding both ciprofloxacin and ceftriaxone resistance in Salmonella.
Emerg Microbes Infect. 2019;8(1):396-403. DOI: 10.1080/22221751.2019.1585965

Dong N, Yang XM, Zhang R, Chan EWC, Chen S*.
Tracking microevolution events among ST11 carbapenemase-producing hypervirulent Klebsiella pneumoniae outbreak strains.
Emerg Microbes Infect. 2018 Aug 12;7(1):146. DOI: 10.1038/s41426-018-0146-6

Zhang R, Dong N, Huang YL, Zhou HW, Xie MM, Chan ECC, Hu Y, Cai JC, Chen S*.
Evolution of tigecycline and colistin resistant CRKP (carbapenem-resistant Klebsiella pneumoniae) in vivo and its persistence in the GI tract.
Emerg Microbes Infect. 2018 Jul 9;7(1):127. DOI: 10.1038/s41426-018-0129-7

Li R, Xie M, Dong N, Lin D, Yang X, Wong MHY, Chan EW, Chen S*. 2018.
Efficient generation of complete sequences of MDR-encoding plasmids by rapid assembly of MinION barcoding sequencing data.
Gigascience 7:1-9. DOI: 10.1093/gigascience/gix132

Chen K, Chan EW, Xie M, Ye L, Dong N, Chen S*.
Widespread distribution of mcr-1-bearing bacteria in the ecosystem.
Euro Surveill. 2017 Sep;22(39). DOI: 10.2807/1560-7917.ES.2017.22.39.17-00206

Yao H, Qin S, Chen S, Shen J, Du XD.
Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae.
Lancet Infect Dis. 2018 Jan;18(1):25. DOI: 10.1016/S1473-3099(17)30628-X

Wong MHY, Shum HP, Chen JHK, Man MY, Wu A, Chan EW, Yuen KY, Chen S*.
Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae.
Lancet Infect Dis. 2018 Jan;18(1):24. DOI: 10.1016/S1473-3099(17)30629-1

Gu D, Dong N, Zheng Z, Lin D, Huang M, Wang L, Chan EW, Shu L, Yu J, Zhang R*, Chen S*.
A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study.
Lancet Infect Dis. 2018 Jan;18(1):37-46. DOI: 10.1016/S1473-3099(17)30489-9

Zhang R, Chan EWC, Zhou HW, Chen S*.
Prevalence and Genetic Characteristics of Carbapenem-resistant Enterobacteriaceae Strains in China.
Lancet Infect Dis. 2017, Mar;17(3):256-257. DOI: 10.1016/S1473-3099(17)30072-5

Zhang R, Liu LZ, Zhou HW, Chan EWC, Li JP, Fang Y, Li Y, Liao K, Chen S*.
Nationwide Surveillance of Clinical Carbapenem-resistant Enterobacteriaceae (CRE) Strains in China.
EBioMedicine 2017 May;19:98-106. DOI: 10.1016/j.ebiom.2017.04.032

Jin K, Sam IH, Po KH, Lin D, Ghazvini Zadeh EH, Chen S*., Yuan Y*, Li X*.
Total synthesis of teixobactin.
Nature communications 2016; 7: 12394. DOI: 10.1038/ncomms12394

Zhang R., Huang YL., Chan EWC., Zhou HW., Chen S*.
Dissemination of the mcr-1 colistin resistance gene.
Lancet Infect Dis. March 2016 Volume 16, No. 3, p291–292. DOI: 10.1016/S1473-3099(16)00062-1

Chiou JC, Wan SB, et al. Chen S*.
Ebselen as a potent covalent inhibitor for New Delhi Metallo-β-lactamase (NDM-1).
ChemComm. May 26;51(46):9543-6. DOI: 10.1039/c5cc02594j

Chen S.; Barbieri, J.T.
Engineering Botulinum Neurotoxin to extend therapeutic intervention.
Proc Natl Acad Sci U S A. 2009, V106(23): 9180-84. DOI: 10.1073/pnas.0903111106.

White D.G., Zhao S., Sudler S., Ayers S., Friedman S., Chen S., McDermott P.F., McDermott S., Wagner D.D., Meng J. (2001)
The Isolation of Antimicrobial-Resistant Salmonella from Retail Ground Meats.
New Engl. J. Med. 18(345)1147-54. PMID: 11642230