Matsuda received his B.Sc. in 2010 and M.Sc. in 2012 from The University of
Tokyo under the direction of Professor Ikuro Abe. After a short period of
experience in industry, he moved back to The University of Tokyo as a Project
Researcher (2012-2013) and was then appointed as an Assistant Professor at the
same university (2013-2015). Meanwhile, he obtained his Ph.D. in Pharmaceutical
Sciences in 2015 from The University of Tokyo. After obtaining his Ph.D. degree,
he moved to the Department of Biotechnology and Biomedicine at Technical
University of Denmark to work with Professor Thomas O. Larsen as a Postdoc
(2015-2017) and subsequently again worked as a Project Researcher at The
University of Tokyo (2017-2018). He joined the City University of Hong Kong as
an Assistant Professor in April 2018, where he is working on biosynthesis and
biosynthetic engineering of natural products.
products exhibit a wide range of biological
activities and have been an attractive and rich
source of compounds for drug discovery, providing
many important pharmaceuticals. Recent advances in
genome sequencing technologies and development of
various molecular biological tools have allowed the
access to many microbial genomes and provided
opportunities to “bioengineer” natural products. By
utilizing these state-of-the-art technologies, the
Matsuda lab aims to further expand the diversity of
natural products and seek to design metabolic
pathways to afford useful compounds, which could
potentially serve as future drug leads. The group’s
current research topics include:
1. Elucidation of the biosynthesis of
complex/bioactive natural products
Genomics-driven discovery and derivatization of
Generation and evolution of “unnatural” natural
(† equal contribution, * corresponding author)
(Full publication list is
Bai, T., Phippen, C.B.W., Nødvig, C.S.,
Kjærbølling, I., Vesth, T.C., Andersen, M.R.,
Mortensen, U.H., Gotfredsen, C.H., Abe, I.,*
Larsen, T.O.* “Novofumigatonin biosynthesis
involves a non-heme iron-dependent endoperoxide
isomerase for orthoester formation.” Nat.
Commun. 9, 2587 (2018).
Senda, M., Sato, H., Yamazaki, M., Uchiyama, M.,
Senda, T., Abe, I. “Structural and computational
bases for dramatic skeletal rearrangement in
anditomin biosynthesis.” J. Am. Chem. Soc.
140, 9743–9750 (2018).
Nakamura, H., Matsuda, Y.,* Abe, I.*
“Unique chemistry of non-heme iron enzymes in
fungal biosynthetic pathways.” Nat. Prod. Rep.
Kjærbølling, I., Vesth, T.C., Frisvad, J.C., Nybo,
J.L., Theobald, S., Kuo, A., Bowyer, P.,
Matsuda, Y., Mondo, S., Lyhne, E.K., Kogle,
M.E., Clum, A., Lipzen, A.M., Salamov, A.A., Ngan,
C.Y., Daum, C.G., Chiniquy, J., Barry, K.W.,
LaButti, K.M., Haridas, S., Simmons, B.A.,
Magnuson, J.K., Mortensen, U.H., Larsen, T.O.,
Grigoriev, I.V., Baker, S.E., Andersen, M.R.
“Linking secondary metabolites to gene clusters
through genome sequencing of six diverse
Aspergillus species.” Proc. Natl. Acad.
Sci. USA 115, E753-E761 (2018).
Mori, T., Iwabichi, T., Hoshino, S., Wang, H.,
Matsuda, Y., Abe, I. “Molecular basis for the
unusual ring reconstruction in fungal
meroterpenoid biogenesis.” Nat. Chem. Biol.
13, 1066-1073 (2017).
Iwabuchi, T., Fujimoto, T., Awakawa, T.,
Nakashima, Y., Mori, T., Zhang, H., Hayashi, F.,
Abe, I. “Discovery of key dioxygenases that
diverged the paraherquonin and
acetoxydehydroaustin pathways in Penicillium
brasilianum.” J. Am. Chem. Soc. 138,
Okada, M.,† Matsuda, Y.,†
Mitsuhashi, T., Hoshino, S., Mori, T., Nakagawa,
K., Quan, Z., Qin, B., Zhang, H., Hayashi, F.,
Abe, I. “Genome-based discovery of an
unprecedented cyclization mode in fungal
sesterterpenoid biosynthesis.” J. Am. Chem.
Soc. 138, 10011-10018 (2016).
Mitsuhashi, T., Lee, S., Hoshino, M., Mori, T.,
Okada, M., Zhang, H., Hayashi, F., Fujita, M.,
Abe, I. “Astellifadiene: Structure determination
by NMR spectroscopy and crystalline sponge method,
and elucidation of its biosynthesis.” Angew.
Chem. Int. Ed. 55, 5785-5788 (2016).
Qin, B.,† Matsuda, Y.,†
Mori, T., Okada, M., Quan, Z., Mitsuhashi, T.,
Wakimoto, T., Abe, I. “An unusual chimeric
diterpene synthase from
variecolor and its functional conversion to a
sesterterpene synthase by domain swapping.”
Angew. Chem. Int. Ed. 55, 1658-1661
Iwabuchi, T., Wakimoto, T., Awakawa, T., Abe, I.
“Uncovering the unusual D-ring construction in
terretonin biosynthesis by collaboration of a
multifunctional cytochrome P450 and a unique
isomerase.” J. Am. Chem. Soc. 137,
Wakimoto, T., Mori, T., Awakawa, T., Abe, I.
“Complete biosynthetic pathway of anditomin:
Nature’s sophisticated synthetic route to a
complex fungal meroterpenoid.” J. Am. Chem.
Soc. 136, 15326-15336 (2014).
Awakawa, T., Wakimoto, T., Abe, I. “Spiro-ring
formation is catalyzed by a multifunctional
dioxygenase in austinol biosynthesis.” J. Am.
Chem. Soc. 135, 10962-10965 (2013).