Dr. H Y SUN

PhD (Singapore)

Associate Professor of Department of Chemistry
Core Member of Centre of Super-Diamond and Advanced Films

drhys

Contact Information

Office: YEUNG-B6716
Phone: +852 3442-9537
Fax: +852 3442-0522
Email: hongysun@cityu.edu.hk
ORCID ID: 0000-0003-0932-6405
Scopus
Author ID:
55729273500

Research Interests

  • Bioorganic chemistry
  • Medicinal chemistry
  • Microarray
  • Cell-based assay
  • Drug action mechanism
  • Biosensor
  • Biomaterial

Dr. Sun received her B.Sc from Wuhan University and Ph.D from the National University of Singapore. Her Ph.D research focuses on systematic enzyme profiling using microarray strategy under the supervision of Professor Shao Qin Yao. She was granted a fellowship from Humboldt Foundation and carried out postdoc research with Professor Herbert Waldmann at Max Planck Institute of Molecular Physiology. Her postdoc studies involve site-specific protein modification and target identification of natural products. She joined the City University of Hong Kong in 2011. Her current research topics include

  1. Developing microarray-based screening platform.

    To identify biologically active peptides using high-throughput screening technology.

  1. Developing novel fluorescent probes for live cell imaging studies.

    To design and synthesize fluorescent probes for bioimaging of various biomolecules.

  1. Developing novel biomaterials for biological application.

    To design and synthesize peptide-based biomaterials for controlled drug delivery and tissue engineering.

Selected Publications: (*corresponding author)

(For full publication list, please visit: http://scholar.google.com.hk/citations?user=OS_INMIAAAAJ&hl=zh-TW)

  • Yang, L.; Peltier, R.; Zhang, M.; Song, D.; Huang, H.; Chen, G.; Chen, Y.; Zhou, F.; Hao, Q.; Bian, L.; He, M. L.;* Wang, Z.;* Hu, Y.;* Sun, H.* Desuccinylation-Triggered Peptide Self-Assembly: Live Cell Imaging of SIRT5 Activity and Mitochondrial Activity Modulation. J. Am. Chem. Soc. 2020, 142, 18150-18159.
  • Xie, Y.; Chen, L.; Wang, R.; Wang, J.; Li, J.; Xu, W.; Li, Y.; Yao, S. Q.; Zhang, L.;* Hao, Q.;* Sun, H.* Chemical Probes Reveal Sirt2's New Function as a Robust "Eraser" of Lysine Lipoylation. J. Am. Chem. Soc., 2019, 141, 18428-18436.
  • Li, X.; Wu, Y.; Tian, G.; Jiang, Y.; Liu, Z.; Meng, X.; Bao, X.; Feng, L.; Sun, H.; Deng, H.; Li, X. D.* Chemical Proteomic Profiling of Bromodomains Enables the Wide-Spectrum Evaluation of Bromodomain Inhibitors in Living Cells. J. Am. Chem. Soc. 2019, 141, 11497-11505.
  • Wang, Y.; Jin, J.; Chung, M.W.H.; Feng, L.; Sun, H.; Hao, Q.* Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation, Proc. Natl. Acad. Sci. U S A. 2018, 115, 2365-2370.
  • Zhang, H.; Xiao, P.; Wong, Y. T.; Shen, W.; Chhabra, M.; Peltier, R.; Jiang, Y.; He, Y.; He, J.; Tan, Y.; Xie Y.; Ho D.; Lam Y. W.;* Sun J.*; Sun H.* Construction of an Alkaline Phosphatase-specific Two-photon Probe and its Imaging Application in Living Cells and Tissues, Biomaterials, 2017, 140, 220-229.
  • Xie, Y.; Ge, J.; Lei, H.; Peng, B.; Zhang, H.; Wang, D.; Pan, S.; Chen, G.; Chen, L.; Wang, Y.; Hao, Q.; Yao, S. Q.; Sun, H.* Fluorescent Probes for Single-Step Detection and Proteomic Profiling of HDACs. J. Am. Chem. Soc., 2016, 138, 15596-15604.
  • Zhang, H.; Liu, R.; Liu, J.; Li, L.; Wang, P.; Yao, S. Q.; Xu, Z.*; Sun, H.*  A Minimalist Fluorescent Probe for Differentiating Cys, Hcy and GSH in Live Cells. Chem. Sci. 2016, 7, 256-260.
  • Chen, G.; Xie, Y.; Peltier, R.; Lei, H.; Wang, P.; Chen, J.; Hu, Y.*; Wang, F.; Yao, X.; Sun, H.* Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery. ACS Appl Mater Interfaces. 2016, 8, 11204-11209.
  • Peltiter, R.; Chen, G.; Lei, H.; Zhang, M.; Gao, L.; Wang, Z.; Sun, H.* The Rational Design of Peptide-based Hydrogel Resonsive to H2S. Chem. Commun. 2015, 51, 17273-17276.
  • Zhang, H.; Zhang, C.; Liu, R.; Yi, L*.; Sun, H.* A highly selective and sensitive fluorescent thiol probe through dual-reactive and dual-quenching groups. Chem. Commun. 2015, 51, 2029-2032. (Back Cover)
  • Zhang, H.; Liu, R.; Tan, Y.; Xie, W. H.; Lei, H.; Cheung, H. Y.; Sun, H.* A FRET-based Ratiometric Fluorescent Probe for Nitroxyl Detection in Living Cells. ACS Appl Mater Interfaces. 2015, 11, 5438-5443.
  • Wang, P.; Na, Z.; Fu, J; Tan, C. Y. J.; Zhang, H.; Yao S. Q.; Sun, H.* Microarray immobilization of biomolecules using a fast trans-cyclooctene (TCO)-tetrazine reaction. Chem. Commun. 2014, 50, 11818-11821. (Back Inside Cover)
  • Wang, P.; Zhang, C. J.; Chen, G. C.; Na, Z.; Yao S. Q.; Sun, H.* Site-specific immobilization of biomolecules by a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole. Chem. Commun., 2013, 49, 8644-8646.
  • Sun, H.;* Chen, G. Y. J.; Yao S. Q.* Recent advances in microarray technologies for proteomics. Chemistry & Biology, 2013, 20, 685-699.
  • Zhang, H.; Wang, P.; Yang, Y.; Sun, H.* A selective fluorescent probe for thiols based on α,β-unsaturated acyl sulfonamide. Chem. Commun., 2012, 48, 10672-10674.
  • Yi, L.;† Sun, H.;† Itzen, A.; Triola, G.; Waldmann, H.; Goody, R. S.; Wu, Y. W. One‐Pot Dual‐Labeling of a Protein by Two Chemoselective Reactions. Angew. Chem. Intl. Ed., 2011, 50, 8287. (;† , equal contribution) )
  • Yi, L.;† Sun, H.;† Wu, Y. W.; Triola, G.; Waldmann, H.; Goody, R. S. A Highly Efficient Strategy for Modification of Proteins at the C Terminus. Angew. Chem. Intl. Ed., 2010, 49, 9417-9421. (;†, equal contribution) (Hot Paper)
  • Sun, H.; Lu, C. H. S.; Uttamchandani, M.; Xia, Y.; Liou, Y.-C.; Yao, S. Q. Peptide Microarray for High-throughput Determination of Phosphatase Specificity and Biology. Angew. Chem. Intl. Ed., 2008, 47, 1698-1702.
  • Lu, C. H. S.; Sun, H.; Bakar, F. B. A.; Uttamchandani, M.; Zhou, W.; Liou, Y.-C.; Yao, S. Q. Rapid Affinity‐Based Fingerprinting of 14‐3‐3 Isoforms Using a Combinatorial Peptide Microarray, Angew. Chem. Intl. Ed., 2008, 47, 7438-7441.
  • Sun, H.; Lu, C. H. S.; Shi, H.; Gao, L.; Yao, S. Q. Peptide Microarrays for High-throughput Studies of Ser/Thr Phosphatases, Nat. Protocols, 2008, 3, 1485-1493.

Patents

  • Christmann, M; Waldmann, H.; Willot, M.; Radtke, L.; Zeigler, S.; Sun, H.; Derivatives of englerin for the treatment of cancer EP10075763.2.