Dr. Sun received her B.Sc from Wuhan University and Ph.D from the National
University of Singapore. Her Ph.D research focuses on systematic enzyme
profiling using microarray strategy under the supervision of Professor Shao Qin
Yao. She was granted a fellowship from Humboldt Foundation and carried out
postdoc research with Professor Herbert Waldmann at Max Planck Institute of
Molecular Physiology. Her postdoc studies involve site-specific protein
modification and target identification of natural products. She joined the City
University of Hong Kong in 2011. Her current research topics include
-
Developing microarray-based screening platform.
To identify biologically active peptides using high-throughput screening technology.
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Developing novel fluorescent probes for live cell imaging studies.
To design and synthesize fluorescent probes for bioimaging of various biomolecules.
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Developing novel biomaterials for biological application.
To design and synthesize peptide-based biomaterials for controlled drug delivery and tissue engineering.
Selected Publications:
(*corresponding author)
(For full publication list,
please visit:
http://scholar.google.com.hk/citations?user=OS_INMIAAAAJ&hl=zh-TW)
- Yang, L.; Peltier, R.; Zhang, M.; Song, D.; Huang, H.; Chen, G.; Chen, Y.; Zhou, F.;
Hao, Q.; Bian, L.; He, M. L.;* Wang, Z.;* Hu, Y.;* Sun, H.* Desuccinylation-Triggered Peptide Self-Assembly:
Live Cell Imaging of SIRT5 Activity and Mitochondrial Activity Modulation. J. Am. Chem. Soc. 2020, 142, 18150-18159.
- Xie, Y.; Chen, L.; Wang, R.; Wang, J.; Li, J.; Xu, W.; Li, Y.; Yao, S. Q.; Zhang, L.;* Hao, Q.;*
Sun, H.* Chemical Probes Reveal Sirt2's New Function as a Robust "Eraser" of Lysine Lipoylation. J. Am.
Chem. Soc., 2019, 141, 18428-18436.
- Li, X.; Wu, Y.; Tian, G.; Jiang, Y.; Liu, Z.; Meng, X.; Bao, X.; Feng, L.; Sun, H.; Deng, H.; Li, X. D.* Chemical Proteomic
Profiling of Bromodomains Enables the Wide-Spectrum Evaluation of Bromodomain Inhibitors in Living Cells. J.
Am. Chem. Soc. 2019, 141, 11497-11505.
- Wang, Y.; Jin, J.; Chung, M.W.H.; Feng, L.; Sun, H.; Hao, Q.* Identification of the YEATS domain of GAS41
as a pH-dependent reader of histone succinylation, Proc. Natl. Acad. Sci. U S A. 2018, 115, 2365-2370.
- Zhang, H.; Xiao, P.; Wong, Y. T.; Shen, W.; Chhabra, M.; Peltier, R.; Jiang, Y.; He, Y.; He, J.; Tan, Y.; Xie Y.; Ho D.;
Lam Y. W.;* Sun J.*; Sun H.* Construction of an Alkaline Phosphatase-specific Two-photon Probe and its Imaging Application in Living Cells
and Tissues, Biomaterials, 2017, 140, 220-229.
- Xie, Y.; Ge, J.; Lei, H.; Peng, B.; Zhang,
H.; Wang, D.; Pan, S.; Chen, G.; Chen, L.; Wang, Y.;
Hao, Q.; Yao, S. Q.; Sun, H.* Fluorescent
Probes for Single-Step Detection and Proteomic
Profiling of HDACs. J. Am. Chem. Soc.,
2016, 138, 15596-15604.
- Zhang, H.; Liu, R.; Liu, J.; Li, L.;
Wang, P.; Yao, S. Q.; Xu, Z.*; Sun, H.*
A Minimalist Fluorescent Probe for
Differentiating Cys, Hcy and GSH in Live Cells.
Chem. Sci. 2016, 7, 256-260.
- Chen, G.; Xie, Y.; Peltier, R.; Lei, H.;
Wang, P.; Chen, J.; Hu, Y.*; Wang, F.; Yao,
X.; Sun, H.* Peptide-Decorated Gold
Nanoparticles as Functional Nano-Capping Agent of
Mesoporous Silica Container for Targeting Drug
Delivery. ACS Appl Mater
Interfaces. 2016, 8,
11204-11209.
- Peltiter, R.; Chen, G.; Lei, H.; Zhang,
M.; Gao, L.; Wang, Z.; Sun, H.* The Rational
Design of Peptide-based Hydrogel Resonsive to H2S.
Chem. Commun. 2015, 51,
17273-17276.
- Zhang, H.; Zhang, C.; Liu, R.; Yi, L*.;
Sun, H.* A highly selective and
sensitive fluorescent thiol probe through
dual-reactive and dual-quenching groups. Chem.
Commun. 2015, 51, 2029-2032. (Back
Cover)
- Zhang, H.; Liu, R.; Tan, Y.; Xie, W. H.;
Lei, H.; Cheung, H. Y.; Sun, H.* A
FRET-based Ratiometric Fluorescent Probe for
Nitroxyl Detection in Living Cells.
ACS Appl Mater Interfaces.
2015, 11, 5438-5443.
- Wang, P.; Na, Z.; Fu, J; Tan, C. Y. J.;
Zhang, H.; Yao S. Q.; Sun, H.*
Microarray immobilization of biomolecules using a
fast trans-cyclooctene (TCO)-tetrazine reaction.
Chem. Commun. 2014, 50, 11818-11821.
(Back Inside Cover)
- Wang, P.; Zhang, C. J.; Chen, G. C.; Na,
Z.; Yao S. Q.; Sun, H.*
Site-specific immobilization of
biomolecules by a biocompatible reaction between
terminal cysteine and 2-cyanobenzothiazole.
Chem. Commun., 2013, 49, 8644-8646.
- Sun, H.;* Chen, G.
Y. J.; Yao S. Q.* Recent advances in microarray
technologies for proteomics. Chemistry &
Biology, 2013, 20, 685-699.
- Zhang, H.; Wang, P.; Yang, Y.; Sun, H.*
A selective fluorescent probe for thiols based on
α,β-unsaturated acyl sulfonamide. Chem. Commun.,
2012, 48, 10672-10674.
- Yi, L.;† Sun, H.;† Itzen, A.; Triola, G.; Waldmann, H.; Goody, R. S.;
Wu, Y. W. One‐Pot Dual‐Labeling of a Protein by Two Chemoselective Reactions.
Angew. Chem. Intl. Ed., 2011, 50, 8287. (;† , equal contribution)
)
- Yi, L.;† Sun, H.;† Wu, Y. W.; Triola, G.; Waldmann, H.; Goody, R. S. A Highly Efficient
Strategy for Modification of Proteins at the C Terminus. Angew. Chem. Intl. Ed., 2010, 49, 9417-9421. (;†,
equal contribution) (Hot Paper)
- Sun, H.; Lu, C. H. S.; Uttamchandani, M.; Xia, Y.; Liou, Y.-C.; Yao, S. Q. Peptide
Microarray for High-throughput Determination of Phosphatase Specificity and Biology. Angew.
Chem. Intl. Ed., 2008, 47, 1698-1702.
- Lu, C. H. S.; Sun, H.; Bakar, F. B. A.; Uttamchandani, M.; Zhou, W.; Liou, Y.-C.; Yao, S. Q.
Rapid Affinity‐Based Fingerprinting of 14‐3‐3 Isoforms Using a Combinatorial Peptide Microarray, Angew.
Chem. Intl. Ed., 2008, 47, 7438-7441.
- Sun, H.; Lu, C. H.
S.; Shi, H.; Gao, L.; Yao, S. Q. Peptide
Microarrays for High-throughput Studies of Ser/Thr
Phosphatases, Nat. Protocols, 2008,
3, 1485-1493.
Patents
- Christmann, M; Waldmann, H.; Willot, M.; Radtke, L.; Zeigler, S.; Sun, H.; Derivatives of englerin
for the treatment of cancer EP10075763.2.