HUANG, Yu (黃聿)

• Member of Biology Panel for Research Assessment Exercise 2026, The University Grants Committee (UGC) of Hong Kong (2024)
• Member of the Biology and Medicine Panel of the Research Grants Council, Hong Kong (December 2017 – 2023)
• Member of the Grant Review Board, Health and Medical Research Fund, Food and Health Bureau, Hong Kong SAR Government (2013–)
• Member of Innovation and Technology Fund (ITF), Hong Kong Government’s Innovation and Technology Commission (2023–)
• Member of Review Panel of Major Research Program on Regulation of Vascular Homeostasis and Remodeling, Natural Science Foundation of China (2014–)
• Panel Member of University of Macau Multi-Year Research Grant in Engineering and Science, University of Macau (2013–2020)
• Chair of the Panel on Biomedical Sciences, the Multi-Year Research Grant, University of Macau (2021–)
• Member of the Academic Committee of the Hong Kong Scholar Program, Hong Kong Special Administrative Region (香江學者計劃, 2011–)

• Vice-President, Chinese Association for Physiological Sciences (中國生理學會副理事長, November 2022)
• Vice-President, The Chinese Section, International Society of Heart Research (國際心臟研究會中國分會副主席, 2016–)
• Vice Chairman of Academic Committee for The Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease Research, Ministry of Education of China (老年心腦血管病教育部重點實驗室學術委員會副主任, January 2024)
• Vice Chairman of Academic Committee for Institute of Endocrine and Metabolic Disease, University of Science and Technology of China and Anhui Provincial Key Laboratory of Metabolic Health and Panvascular Diseases (中國科學技術大學內分泌与代謝病研究所, 代謝建康与渙血管病安徽省重點實驗室學術委員會副主任, August 2023)
• Vice-President, Society of Vascular Medicine, Chinese Association of Pathophysiology (中國病理生理學會心血醫學專業委員會副主任委員, 2015–2021)
• President, Asian Society for Vascular Biology (2010–2018)
• Secretary-General and the founding member of the Asian Society for Vascular Biology (2005–2010)
• Council Member, the Asian Society for Vascular Biology (2018–)
• Elected voting member (representing Asia) of the five-member Membership Committee, the International Union of Basic and Clinical Pharmacology (2006–2018)
• Corresponding member of the International Union of Basic and Clinical Pharmacology (IUPHAR) Committee on Receptor Nomenclature and Drug Classification (2011–)
• Member of the Scientific Committee, State Key Laboratory of Cardiovascular Disease (心血管疾病國家重點實驗室學術委員會委員, April 2022–)
• Member of the Committee of Experts on National Center for Cardiovascular Diseases (中國國家心血管專家委員會第二届委员会委員, September 2019–)
• Executive Council Member, Cardiovascular Immunology Sub-Committee, Chinese Society for Immunology (中國免疫學會心血管免疫分會常務理事, June 2024 – 2028)
• Elected Executive Council Member of the Chinese Association for Physiological Sciences (中國生理學會常務理事, November 2022–)
• Council Member, The Chinese Association of Pathophysiology (中國病理生理學會理事, 2010–)
• Elected Council Member, The Chinese Society of Cardiovascular Pathophysiology (中國病理生理學會心血管專業委員會理事, 2008–)
• Council Member, Society of Vascular Medicine, Chinese Association of Pathophysiology (中國病理生理學會心血醫學專業委員會理事, 2015–)
• Council Member of the Chinese Section, the International Society of Heart Research (國際心臟研究會中國分會理事, 2008–)
• Council Member of The International Society for Heart Research – Chinese Committee of Translational Medicine (ISHR-CCTM, 2014–2016)
• Executive Council Member of The International Society for Heart Research – Chinese Committee of Translational Medicine (ISHR-CCTM, 國際心臟研究會中國轉化醫學工作委員會常務理事, 2016–)
• Executive Council Member, The Chinese Society of Cardiovascular Pharmacology (中國藥理學會心血管專業委員會常務理事, 2007–)
• Elected Council Member, The Chinese Society of Circulatory Physiology, Chinese Association for Physiological Sciences (中國生理學會循环生理專業委員會理事, 2015–2018)
• Executive Council Member, 2nd Board of Specialty Committee of TCM Pharmacology, World Federation of Chinese Medicine Societies (世界中醫藥學會聯合會中藥藥理專業委員會常務理事, January 2014 – 2018)
• Member of Public Affair Committee, The Academy of Cardiovascular Research Excellence, USA (2003–)
• 第三屆海峽兩岸醫藥衛生交流協會心血管專業委員會常務委員 (2021–)
• Executive Council Member (2000–2001) and Treasurer (2001–2008), Hong Kong Society of Neurosciences
• Executive Committee Member (2003–), Honorary Secretary (2006–2008), and Treasurer (2009–2012), Hong Kong Pharmacology Society
• Vice-President, Hong Kong Society of Cell Biology (2018–)
• Council Member, Institute of Cardiovascular Science and Medicine, Hong Kong (2008–)
• Deputy Director, Institute of Cardiovascular Science and Medicine, Hong Kong (2023–)
• Secretary (Internal Affair, 2011–2013), Vice-President (External Affair, 2013–2015, 2015–2017, 2017–2020), Council Member (2021–2023) for The Society of Hong Kong Scholars

• Associate Editor, Experimental Physiology (London, 2002 –2003)
• Editor, Experimental Physiology (London, 2003–2006)
• Editor (Vascular), Clinical and Experimental Pharmacology and Physiology (Australia, 2007–2012)
• Editor, Drug Discoveries & Therapeutics (Japan, 2008–)
• Editor, Naunyn-Schmiedeberg's Archives of Pharmacology (Europe, 2012–2019)
• Reviewer Editor, Frontiers in Pharmacotherapy of Inflammation (Switzerland, 2010–), Frontiers in Cardiovascular and Smooth Muscle Pharmacology (Switzerland, 2010–); Frontier in Vascular Physiology (Switzerland, 2010–); Frontiers in Ethnopharmacology (Switzerland, 2013–)
• Academic Editor, PLoS One (2011–2019, USA)
• Associate Editor (Cardiovascular), Clinical and Experimental Pharmacology and Physiology (2014–2018)
• Co-Guest Editor for Journal of Cardiovascular Pharmacology (USA, 2014–2015)
• Co-Guest Editor for British Journal of Pharmacology (UK, 2016–2017)
• Editor for British Journal of Pharmacology (UK, 2018–)
• Associate Editor, Circulation Research (American Heart Association, USA, 2019–)
• Co-Guest Editor for Journal of Molecular and Cellular Cardiology (USA, 2021–2022)
• Co-Guest Editor for Antioxidants (2021–2022)
• Member of Editorial Board or Editorial Advisory Board (past and present) for SCI-indexed journals including
  • Journal of Vascular Research, Europe (2007–2018)
  • Cardiovascular Drug & Therapy, Europe (2011–)
  • The Journal of Pharmacy and Pharmacology (UK, 2011–)
  • American Journal of Cardiovascular Disease (USA, 2011–)
  • Advanced Biomedical Research (2012)
  • Arteriosclerosis, Thrombosis and Vascular Biology (USA, 2012–)
  • Acta Pharmacologica Sinica (China, 2012–)
  • Journal of Cardiovascular Diseases & Diagnosis (USA, 2013–)
  • Clinical and Experimental Research in Cardiology (USA, 2014–)
  • World Journal of Traditional Chinese Medicine (2014–2016)
  • Scientific Reports (UK, 2014–2019)
  • Biomedical Research (2016–)
  • British Journal of Pharmacology (UK, 2018–)
  • Cardiovascular Research (Europe, 2018–)
  • Journal of Molecular and Cellular Cardiology (USA, 2018–)
• Member of Editorial Board (past and present) for Chinese scientific journals including
  • Chinese Journal of New Drugs and Clinical Remedies (2004–)
  • Journal of Chinese Clinical Medicine (English Edition) (2006–2012)
  • Acta Physiological Sinica (2011–)
  • Journal of Physiology Studies (2013–)
  • Medical Review (2023–)

• Keynote Lecture at the 7th Asia-Pacific CardioMetabolic Syndrome Congress (APCMS), Seoul, Korea, 26 April 2024
• 2024 Peter Harris Distinguished Scientist Award Lecture at ISHR Chinese Section Scientific Meeting, Wuxi, China, 12 April 2024
• Keynote Lecture at 8th International Conference on Biomedical Engineering and Applications (ICBEA 2024), Tokyo, Japan, 19 March 2024
• Bei Shi Zhang Lecture (貝時璋講座) in University of Science and Technology of China, Anhui, China, 18 August 2023
• Keynote Lecture at 2023 Scientific Conference of Malaysian Society of Pharmacology and Physiology, Malaysia, 7 August 2023
• Keynote Lecture at Chinese Congress on Redox Biology and Medicine, Xiamen, 12 August 2023
• Keynote Lecture at 19th World Congress of Basic and Clinical Pharmacology – WCP2023, Glasgow, Scotland, 4 July 2023
• The President’s Lecture, City University of Hong Kong, 2 November 2022
• The Annual CPS Keynote Lecture at 2018 Joint Annual Conference of Biomedical Science (JACBS), Taipei, 23–25 March 2018
• The 9th Asian Lecture on Vascular Biology at 8th Scientific Meeting of Asian Society for Vascular Biology, Shanghai, China, 3 November 2018
• The Robert F. Furchgott Lecture at the 11th International Symposium on Mechanisms of Vasodilatation (MOVD 2013, Zurich, Switzerland, 4 October 2013
• Invited Institute of Vascular Medicine Keynote Lecture at Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine, Hong Kong, 1 November 2014
• The Office of Life Sciences Distinguished Lecture at National University of Singapore, 26 April 2007

• Fudan University Shanghai Medical College (2005)
• Xi’an Jiaotong University Medical Centre (2005)
• Center of Medical Sciences, Guangdong Provincial People’s Hospital (2006)
• Shanghai Jiaotong University Medical College (2007)
• Jinan University (2008)
• Peking University, School of Basic Medical Sciences (2010)
• Third Military Medical University (2010)
• Beijing Institute of Heart, Lung and Blood Vessel Diseases (2017)
• University of Science and Technology of China (2023)
• Member of Scientific Committee, Shanghai City Vascular Biology Key Laboratory (2007)
• Member of Academic Committee, Shanghai City Key Laboratory of Hypertension (2014)
• Member of Academic Committee, Center for Obesity and Metabolic Disease at Peking University, China (2010)
• Member of Academic Committee of Advanced Institute of Medical Sciences, Dalian Medical University (2015)
• Member of Academic Committee for Shenzhen Key Laboratory of Metabolism and Cardiovascular Homeostasis

• External Assessor of The Chang Jiang Scholars Program, The Ministry of Education and Li Ka Shing Foundation, China (教育部長江學者講座教授, 特聘教授,成就獎評審專家)
• 中央組織部人才工作局青年拔尖人才支援計畫評審專家
• 中國青年千人計劃通信評審專家庫專家
• 中國國家科技獎勵評審專家 (2015年度國家自然科學獎會評專家,生物學組)
• 家自然科學基金委員會醫學科學部科學國家傑出青年基金
• 國家自然科學基金委員會醫學科學部科學國家優秀青年基金
• External member of the University Assessment Panel for the “UM Macao Talent Program澳大濠江人才計劃 (UMMTP)” on “UM Macao Post-doctoral Fellowship” and the “UM Macao Distinguished Visiting Scholar”
• Regular reviewer of manuscripts for 255 international journals and of abstracts for 13 international conferences
• Regular reviewer of grant proposals for 36 granting agencies and schemes of 15 countries and regions
• 452 invited lectures and seminars at international, regional and local conferences on vascular research

2024

• Ding H, Jiang M, Chan AM, Xia Y, Ma RCW, Yao X, Wang L, *Huang Y (2024) Targeting endothelial Src attenuates disturbed flow-induced inflammation and atherogenesis. British Journal of Pharmacology (Accepted)
• He C, Zhu R, He L, Chook CYB, Li H, Leung FP, Tse G, Chen ZY, *Huang Y, *Wong WT (2024) Asperuloside as a Novel NRF2 Activator to Ameliorate Endothelial Dysfunction in High Fat Diet-Induced Obese Mice. Antioxidants & Redox Signaling (Accepted)
• Cheng CK, Gao J, Kang LJ, *Huang Y (2024) Fecal microbiota transfer from young mice reverts vascular aging hallmarks and metabolic impairments in aged mice. Aging and Disease 2024 Jul 9. doi:10.14336/AD.2024.0384. Online ahead of print.
• Zhao Y, Wang L, Huang Y, Evans PC, Little PJ, Tian X, Weng J, Xu S (2024) Anthocyanins in vascular health and disease: mechanisms of action and therapeutic potential. Journal of Cardiovascular Pharmacology June 25, 2024. doi: 10.1097/FJC.0000000000001602
• Xu MY, Xu JJ, Kang LJ, Liu ZH, Su MM, Zhao WQ, Wang ZH, Lu S, Xiao JB, Evans PC, Tain XY, Wang L, Huang Y, Liang XM, Weng JP, Xu SW (2024) Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipop rotein E-deficient mice. Acta Pharmacologica Sinica2024 Jun 17. doi: 10.1038/s41401-024-01317-5. Online ahead of print.
• Liang X, Wang Z, Cai H, Zeng YQ, Chen J, Wei X, Dong G, Huang Y, Lao XQ (2024) Outdoor light at night and mortality in the UK Biobank: a prospective cohort study. Occupational and Environmental Medicine 2023 Nov 22:oemed-2023-109036. doi: 10.1136/oemed-2023-109036. Online ahead of print
• He L, Chen QH, Wang L, Pu YJ, Huang J, Cheng CK, Luo JY, Kang LJ, Lin X, Xiang L, Fang L, He B, Xia Y, Lui KO, Pan Y, Liu J, Zhang CL, *Huang Y (2024) Activation of Nrf2 inhibits atherosclerosis in ApoE-/- mice through suppressing endothelial cell inflammation and lipid peroxidation. Redox Biology 74:103229. doi: 10.1016/j.redox.2024.103229
• Chen Q, Hao H, Guo Z, Zuo Y, Cheng CK, Zhang CL, Wang L, Lu A, *Huang Y, He L (2024) Pien Tze Huang (PZH) Protects Endothelial Function in Diabetic Mice. Life Sciences 349:122723. doi;10.1016/j.Ifs.2024.122723
• Li X, Luo W, Tang Y, Wu J, Zhang J, Chen S, Zhou L, Tao Y, Tang Y, Wang F, Huang Y, Jose PA, Guo L, Zeng C (2024) Semaglutide Attenuates Doxorubicin-Induced Cardiotoxicity through Improving Bnip3-Mediated Mitochondrial Dysfunction. Redox Biology 72(2024):103129. doi: 10.1016/j.redox.2024. 103129.
• Maxwell S, Okabe J, Kaipananickal H, Rodriguez H, Khurana I, Al-Hasani K, Chow BSM, Pitsillou E, Karagiannis TC, Jandeleit-Dahm K, Ma RCW, Huang Y, Chan JCN, Cooper ME, El-Osta A (2024) Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells. Journal of the American Society of Nephrology 35(6):733-748. doi: 10.1681/ASN.0000000000000345.. With Commentary, Doke, Tomohito; Bjornstad, Petter, Journal of the American Society of Nephrology 35(6):p 670-672
• Xiang L, Wang L, Xia Y, Wang Y, Shui J, Zhang CL, Xie L, Ru Y, Cheng CK, Pu Y, Hu L, Liu J, Xu S, Cai ZW, *Huang Y (2024) Exercise Alleviates Diabetic Kidney Disease Through PPARd-CPT1a pathway-dependent Fatty Acid β-oxidation. The Innovation Life 2(2):100065 (10 pages)
• Liu Y, Wang Y, Xu C, Zhang Y, Wang Y, Qin J, Lan HY, Wang L, Huang Y, Mak K, Zheng Z, Xia Y (2024) Activation of the YAP/KLF5 transcriptional cascade in renal tubular cells aggravates kidney injury. Molecular Therapy 32(5):1526-1539. doi: 10.1016/j.ymthe.2024.02.031.
• Jin Q, Lau ESH, Luk AO, Tam CHT, Ozaki R, Lim CKP, Wu H, Chow EYK, Kong APS, Lee HM, Fan B, Ng ACW, Jiang G, Lee KF, Siu SC, Hui G, Tsang CC, Lau KP, Leung JY, Tsang MW, Cheung EYN, Kam G, Lau IT, Li JK, Yeung VT, Lau E, Lo S, Fung S, Cheng YL, Chow CC, Yu W, Tsui SKW, Tomlinson B, Huang Y, Lan H, Szeto CC, So WY, Jenkins AJ, Fung E, Muilwijk M, Blom MT, Leen M. ‘t Hart, Chan JCN, Ma RCW on behalf of the Hong Kong Diabetes Biobank Study Group (2024) Circulating metabolomic markers linking diabetic kidney disease and incident cardiovascular disease in type 2 diabetes: association and mediation analyses from the Hong Kong Diabetes Biobank. Diabetologia 67(5):837-849. doi: 10.1007/s00125-024-06108-5.
• Bo Y, Lin C, Guo C, Wong M, Huang B, Lau A, Huang Y, Lao XQ (2024) Chronic exposure to ambient air pollution and the risk of non-alcoholic fatty liver disease: A cross-sectional study in Taiwan and Hong Kong. Ecotoxicology and Environmental Safety 275:116245.doi: 10.1016/j.ecoenv.2024.116245.
• Ye P, Deng Y, Gu Y, Liu P, Luo J, Pu J, Chen J , Huang Y, Wang N , Ji Y, Chen S (2024) GRK2–YAP signaling is implicated in pulmonary arterial hypertension development. Chinese Medical Journal (Engl) 137(7):846-858. doi: 10.1097/CM9.0000000000002946.
• Yuan W, Lin H, Sun Y, Liu L, Yan M, Song Y, Zhang X, Lu X, Xu Y, He Q, Ouyang K, Zhang C, Pan Y, Huang Y, Li Y, Lu X, Liu J (2024) Myocardin reverses insulin resistance and ameliorates cardiomyopathy by increasing IRS-1 expression in a murine model of lipodystrophy caused by adipose deficiency of vacuolar H+-ATPase V0d1 subunit. Theranostics 14(5):2246-2264. doi: 10.7150/thno.93192.
• Huang YH, Wang YF, Ruan XZ, Lau CW, Wang L, *Huang Y (2024) The Role of KLF2 in Regulating Hepatic Lipogenesis and Blood Cholesterol Homeostasis via the SCAP/SREBP Pathway. Journal of Lipid Research 65(1):100472.doi: 10.1016/j.jlr.2023.100472

2023

• Jiang M, Ding H, Huang Y, Cheng CK, Lau CW, Xia Y, Yao X, Wang L, *Huang Y (2023) Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation. Acta Pharmacologica Sinica 44(10):1977-1988.
• Pu Y, Cheng CK, Zhang H, Luo J, Wang L, Tomlinson T, *Huang Y (2023) Molecular mechanisms and therapeutic perspectives of peroxisome proliferator-activated receptor α agonists in cardiovascular health and diseases. Medicinal Research Reviews 43(6):2086-2114.
• Cheng CK, *Huang Y (2023) Oral microbiome: a doubtful predictor but potential target of cardiovascular diseases. Medical Review 3(3):209-213.
• Kang L, Yi J, Lau CW, He L, Chen Q, Xu S, Li J, Xia Y, Zhang Y, Huang Y, Wang L (2023) AMPK-dependent YAP inhibition mediates the protective effect of metformin against obesity-associated endothelial dysfunction and inflammation. Antioxidants 2023,12(9):1681 (16 pages)
• Luo JY, Cheng CK, Gou L, He L, Zhao L, Zhang Y, Wang L, Lau CW, Chen AF, *Huang Y (2023) Induction of KLF2 by exercise activates eNOS to improve vasodilatation in diabetic mice. Diabetes 72(9):1330-1342
• Cheng CK, Ding H, Jiang M, Yin H, Gollasch M, *Huang Y (2023) Perivascular adipose tissue: Fine-tuner of vascular redox status and inflammation. Redox Biology 62:102683
• Tam CHT, Lim CKP, Luk AOY, Shi M, Cheung HM, Ng ACW, Lee HM, Lau ESH, Fan B, Jiang G, Kong APS, Ozaki R, Chow EYK, Lee KF, Siu SC, Hui G, Tsang CC, Lau KP, Leung JYY, Cheung EYN, Tsang MW, Kam G, Lau IT, Li JKY, Yeung VTF, Lau E, Lo S, Fung S, Cheng YL, Chow CC, The Hong Kong Diabetes Biobank Study Group, FIELD Study investigators, Fan X, Chan TF, Yip KYL, Lok S, Yu W, Tsui SKW, Lan HY, Szeto CC, Tang NLS, Tomlinson B, Huang Y, Jenkins AJ, Keech A, So WY, Chan JCN, Ma RCW, for the TRANSCEND Consortium (2023) Identification of a common variant for coronary heart disease at PDE1A contributes to individualized treatment goals and risk stratification of for cardiovascular complications in Chinese patients with type 2 diabetes. Diabetes Care 46(6):1271-1281.
• Ding H, Jiang M, Lau CW, Luo J, Chan AM, Wang L, *Huang Y (2023) Curaxin CBL0137 inhibits endothelial inflammation and atherogenesis via suppression of Src-YAP signaling axis. British Journal of Pharmacology 180(8):1168-1185.
• Hou C, Cao C, Ma R, Ai L, Hu Z, Huang Y, Yao X (2023) Press-N-Go On-Skin Sensor with High Interfacial Toughness for Continuous Healthcare Monitoring ACS Applied Materials & Interfaces 15(8):11379-11387
• Wang C, Wu Y, Li Y, Zhang Y, Fung YK, Tong KK, Lau CW, Xiang L, Kwan KM, You LR, *Huang Y, *Tian XY (2023) Smad4-mediated angiogenesis facilitates beiging of white adipose tissue in mice. iScience 26(3):106272 (17 pages)
• Zhang Y, Huang H, Kong Y, Xu C, Dai L, Geng X, Deng Y, Wang Y, Liu Y, Meng C, Zhang X, Li J, Qin J, Feng B, Mak KK, Wang L, Huang Y, Wang W, Lan HY, Yang B, Lu HAJ, Xia Y (2023) Kidney tubular transcription co-activator, Yes-associated protein 1 (YAP), controls the expression of collecting duct aquaporins and water homeostasis. Kidney International 103(3):501-513
• Bei Y, Chen C, Hua X, Yin M, Meng X, Huang Z, Liu C, Lehmann HI, Li G, Huang Y, Xiao J (2023) A modified apical resection model with high accuracy and reproducibility in neonatal mouse and rat hearts. npj Regenerative Medicine 8(1):9, 13 pages
• Khurana I, Harikrishnan KN, Maxwell S, Birkelund S, Syreeni A, Forsblom C, Okabe J, Ziemann M, Kaspi A, Rafehi H, Jørgensen A, Al-Hasani K, Thomas MC, Jiang G, Luk AOY, Lee HM, Huang Y, Thewjitcharoen Y, Nakasatien S, Himathongkam T, Fogarty C, Njeim R, Eid A, Hansen TW, Tofte N, Ottesen EC, Ma RCW, Chan JCN, Cooper ME, Rossing P, Groop P, El-Osta A (2023) Reduced methylation corresponds with T1D nephropathy risk, Journal of Clinical Investigator 133(4):e160959
• Chen H, Peng J, Wang T, Wen J, Chen S, *Huang Y, Zhang Y (2023) Counter-regulatory renin-angiotensin system in hypertension: review and update in the era of COVID-19 pandemic. Biochemical Pharmacology 208 (2023):115370
• Xiang L, Ru Y, Shi J, Wang L, Zhao H, *Huang Y, Cai Z (2023) Derivatization of N-Acyl Glycines by 3-Nitrophenylhydrazine for Targeted Metabolomics Analysis and Their Application to the Study of Diabetes Progression in Mice. Analytical Chemistry 95(4):2183-2191.
• Cheng CK, Lin X, Pu Y, Tse KYJ, Wang Y, Zhang CL, Cao X, Lau CW, Huang J, He L, Luo JY, Shih YT, Wan S, Ng CF, Wang L, Ma CWR, JJ Chiu, Chan TF, Tian XY & *Huang Y (2023) SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis. Journal of Advanced Research 43:187-203.

2022

• Jin Q, Lau ESH, Luk AO, Tam CHT, Ozaki R, Lim CKP, Wu H, Chow EYK, Kong APS, Lee HM, Fan B, Ng ACW, Jiang G, Lee KF, Siu SC, Hui G, Tsang CC, Lau KP, Leung JY, Tsang MW, Cheung EYN, Kam G, Lau IT, Li JK, Yeung VT, Lau E, Lo S, Fung S, Cheng YL, Chow CC, Yu W, Tsui SKW, Huang Y, Lan HY, Szeto CC, So WY, Jenkins AJ, Chan JCN, Ma RCW (2022) High-density lipoprotein subclasses and cardiovascular disease and mortality in type 2 diabetes: analysis from the Hong Kong Diabetes Biobank. Cardiovascular Diabetology 21(1):293.
• Lui KO, Huang Y (2022) Prohibitin 2 governs glucose metabolism and phenotypic switching of vascular smooth muscle cells during vascular remodeling. Circulation Research (Editorial) 131(10):825-827
• Jiang M, Ding H, *Huang Y & Wang L (2022) Shear Stress and Metabolic Disorders-Two Sides of the Same Plaque. Antioxidants & Redox Signaling 37(10-12): 820-841.
• Huo M, Cao X, Zhang H, Lau CW, Hong H, Chen FM, Huang Y, Chawla A & Tian XY (2022) Loss of Myeloid Bmal1 Exacerbates Hypertensive Vascular Remodelling Through Interaction with STAT6 in Mice. Cardiovascular Research 118(13):2859-2874.
• Luo JY, Cheng CK, He L, Pu Y, Zhang Y, Lin X, Xu A, Lau CW, Tian XY, Ma RCW, Jo H & *Huang Y (2022) Endothelial UCP2 is a mechanosensitive suppressor of atherosclerosis. Circulation Research 131(5):424-441.
• Wan Q, Xu C, Zhu L, Zhang Y, Peng Z, Chen H, Zhang E, Wu Y, Wang H, Chu F, Yuan J, Huang Y, Hu S, Liu DP, Wang M (2022) Targeting PDE4B (phosphodiesterase-4 subtype B) for cardioprotection in acute myocardial infarction via neutrophils and microcirculation. Circulation Research 131(5):442-455.
• Zhang H, Dong J, Lau CW, Wei Y & *Huang Y (2022) Berberine reverses nitroglycerin tolerance through suppressing PKCa activity in vascular smooth muscle cells. Cardiovascular Drugs and Therapy 36(4):633-643
• Zhang Y, Wang Y, Zheng G, Liu Y, Li J, Huang H, Xu C, Zeng Y, Zhang X, Qin J, Dai C, Hambrock HO, Hartmann U, Feng B, Mak KK, Liu Y, Lan HY, Huang Y, Zheng ZH Xia Y (2022) Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo. Journal of Biological Chemistry 298(7):102010
• He L, Zhang CL, Chen QH, Wang L & *Huang Y (2022) Endothelial shear stress signal transduction and atherosclerosis: From mechanisms to therapeutics. Pharmacology & Therapeutics 235; (2022) 108152
• Zhang H, Xiang L, Huo M, Wu Y, Yu M, Lau CW, Tian D, Gou L, Huang Y, Luo JY, Wang L, Song W, Huang J, Cai Z, Chen S, Tian XY & *Huang Y (2022) Branched-chain amino acid supplementation Impairs Insulin Sensitivity and Promotes Lipogenesis During Exercise in Diet-Induced Obese Mice. Obesity (Silver Spring). 30(6):1205-1218.
• Cheng CK, Shang W, Liu J, Cheang WS, Wang Y, Xiang L, Lau CW, Luo JY, Ng CF, *Huang Y, *Wang L (2022) Activation of AMPK/miR-181b Axis Alleviates Endothelial Dysfunction and Vascular Inflammation in Diabetic Mice. Antioxidants 11(6):1137 (17 pages)
• Zhang H, Peng L, Wang Y, Zhao W, Lau WB, Wang Y, Li Y, Du Y, Li L, Huang Y, Nie S, Qin Y, Ma X, Wei Y (2022) Extracellular vesicle-derived miR-144 as a novel mechanism for chronic intermittent hypoxia-induced endothelial dysfunction. Theranostics 12(9): 4237-4249. doi:10.7150/thno.69035
• Lifang Han; Gang Wang; Shaopu Zhou; Chenghao Situ; Zhiming He; Yuying Li; Yu Huang; Aimin Xu; Michael Tim Yun Ong; Huating Wang; Jianfa Zhang; Zhenguo Wu (2022) Muscle Satellite Cells are impaired in Type 2 Diabetic Mice by Elevated Extracellular Adenosine. Cell Reports 39(10):110884.
• Zhang C, He L, Wang L & *Huang Y (2022) The pathogenesis of endothelial dysfunction (內皮功能障礙的發生機制) SCIENTIA SINICA Vitae (中國科學：生命科學) 52(5):691-698.
• Zhao L, Zhang CL, He L, Chen QH, Liu L, Kang L, Liu J, Luo JY, Gou L, Qu D, Song W, Lau CW, Ko H, Mok VCT, Tian XY, Wang L & *Huang Y (2022) Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Reducing Mitochondrial ROS-mediated eNOS Monomerization. Diabetes 71(5):1099-1114. doi: 10.2337/db21-0660
• Wang L, Cheng CK, Yi M, Lui KO, *Huang Y (2022) Targeting endothelial dysfunction and inflammation. Journal of Molecular and Cellular Cardiology 168:58-67.
• Ma Z, Li X, Fan RLY, Yang KY, Ng CSH, Lau RWH, Wong RHL, Ng KK, Wang CC, Ye P, Fu Z, Chin AWH, Lai MYA, Huang Y, Tian XY, Poon LLM, Lui KO (2022) A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4. Stem Cell Reports 17(3):538-555.
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