Dr Terrence C. K. Lau (劉智剛博士)

PhD (PolyU)

Associate Head and Associate Professor

Dr Terrence C. K. Lau

Contact Information

Office: 1B-202, 2/F, Block 1,
To Yuen Building
Phone: +852 3442-9327
Fax: +852 3442-0549
Email: chiklau@cityu.edu.hk
Web: CityU Scholars

Research Interests

  • RNA Biology and Technology
  • RNA Biogenesis
  • Structural and Chemical Biology
  • Molecular Microbiology

Dr Terrence Lau received his PhD in biochemistry at The Hong Kong Polytechnic University in 1999. After receiving his PhD, he moved to United States and started his post-doctoral training at Prof. Gregory Van Duyne’s laboratory at University of Pennsylvania (UPenn), Philadelphia, where he developed his interest in the structure/function relationship of RNA/protein complex and their functional roles in the cell. He then joined the group of Prof. Gideon Dreyfuss at Howard Hughes Medical Institute (UPenn) and studied the relationship between the RNA biogenesis and the pathogenesis of Spinal Muscular Atrophy, one of the most common genetic diseases in U.S. Before he joined the City University of Hong Kong in 2011, he worked as a research assistant professor in the School of Biomedical Sciences at Chinese University of Hong Kong. His research focuses on understanding the functional roles of non-coding RNA and RNA/protein complexes in prokaryotes and eukaryotes, and the application of RNA technology.

Publications

  • Lau SKP, Wong ACP, Lau TCK, Woo PCY. "Molecular Evolution of MERS Coronavirus: Dromedaries as a Recent Intermediate Host or Long-Time Animal Reservoir?", Int J Mol Sci., Vol. 18(10), pii: E2138 (2017) doi: 10.3390/ijms18102138. PMID:29035289
  • Jiang X, Liu X, Law COK, Wang Y, Lo WU, Weng X, Chan TF, Ho PL, Lau TCK. "The CTX-M-14 plasmid pHK01 encodes novel small RNAs and influences host growth and motility", FEMS Microbiol Ecol., Vol. 93(7) (2017) doi: 10.1093/femsec/fix090. PMID:28854680
  • Cheung AKL, Kwok HY, Huang Y, Chen M, Mo Y, Wu X, Lam KS, Kong HK, Lau TCK, Zhou J, Li J, Cheng L, Kiat Lee B, Peng Q, Lu X, An M, Wang H, Shang H, Zhou B, Wu H, Xu A, Yuen KY, Chen Z. "Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection", Nat Microbiol., Vol. 2(10), pp. 1389-1402 (2017) doi: 10.1038/s41564-017-0006-5. PMID:28808299
  • Tam KK, Leung KS, To SW, Siu GK, Lau TC, Shek VC, Tse CW, Wong SS, Ho PL, Yam WC. "Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realtime MTB detection and RIF/INH resistance assay", Diagn Microbiol Infect Dis., Vol. 89(2), pp. 118-124 (2017) doi: 10.1016/j.diagmicrobio.2017.06.018. PMID: 28780247
  • Kong HK, Law HW, Liu X, Law CO, Pan Q, Gao L, Xiong L, Lau SK, Woo PC, Lau TC. "Transcriptomic Analysis of Laribacter hongkongensis Reveals Adaptive Response Coupled with Temperature", PLoS One, Vol. 12(1), e0169998 (2017) doi: 10.1371/journal.pone.0169998. PMID: 28085929
  • Ma, R.C., Lee, H.M., Lam, V.K., Tam, C.H., Ho, J.S., Zhao, H.L., Guan, J., Kong, A.P., Lau, E., Zhang, G., Luk, A., Wang, Y., Tsui, S.K., Chan, T.F., Hu, C., Jia, W.P., Park, K.S., Lee, H.K., Furuta, H., Nanjo, K., Tai, E.S., Ng, D.P., Tang, N.L., Woo, J., Leung, P.C., Xue, H., Wong, J., Leung, P.S., Lau, T.C.K., Tong, P.C., Xu, G., Ng, M.C., So, W.Y., Chan, J.C. “Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese”, PLoS One, Vol. 9, e84770 (2014)
  • Hu, X., Wong, T.K., Lu, Z.J., Chan, T.F., Lau, T.C.K., Yiu, S.M., Yip, K.Y. “Computational identification of protein binding sites on RNAs using high-throughput RNA structure-probing data”, Bioinformatics, Vol. 30, pp. 1049-1055 (2014)
  • Ho, P.L., Chan, J., Lo, W.U., Lai, E.L., Cheung, Y.Y., Lau, T.C.K., Chow, K.H. “Prevalence and molecular epidemiology of plasmid-mediated fosfomycin resistance gene fosA3 among blood and urinary Escherichia coli isolates”, Journal of Medical Microbiology, Vol. 62, pp. 1707-1713 (2013)
  • Li, S.K., Zhou, J.W., Yim, A.K.Y., Leung, A.K.Y., Tsui, S.K.W., Chan, T.F., Lau, T.C.K. “Organism-specific rRNA capture system for application in Next-Generation Sequencing”, PloS One, Vol. 8, e74286 (2013)
  • Li, S.K., Ng, P.K.S., Hao, Q., Lau, J.K.Y., Lau, J.P.Y., Chan, T.F., Tsui, S.K.W. and Lau, T.C.K. “Identification of small RNAs in Mycobacterium Smegmatis using heterologous Hfq”, RNA, Vol. 1, pp. 74-84 (2013)
  • Chan, T.M.*, Leung, K.S., Lee, K.H., Wong, M.H., Lau, T.C.K.* and Tsui, S.K.W. “Subtypes of associated protein-DNA (TF-TFBS) patterns”, Nucleic Acids Research, Vol. 40, pp. 9392-9403 (2012) (*co-corresponding authors)
  • Zhang, J., Zhou, J.W., Chan, C.F., Lau, T.C.K.*, Kwong, D.W.J., Mak, N.K., Tam, H.L., Wong, K.L.* and Wong W.K.* “Comparative Studies of the Cellular Uptake, Subcellular Localization, Cytotoxic and Phototoxic Anti-tumor Properties of Ruthenium(II)-Porphyrin Conjugates with Different Linkers”, Bioconjugate Chemistry, Vol. 23, pp. 1623-1638 (2012) (*co-corresponding authors)
  • Tsoi, Ho, Lau, T.C.K., Tsang, F., Lau, K.F. and Chan, H.Y.E. “CAG expansion induces nucleolar stress in polyglutamine diseases”, Proceedings of National Academy of Sciences, Vol. 109, pp. 13428-13433 (2012)
  • Kang, Y., Wu, Z., Lau, T.C.K., Lu, X., Liu, L., Cheung, A.K., Tan, Z., Ng, J., Liang, J., Wang, H., Li, S.K., Zheng, B., Li, B., Chen, L. and Chen, Z. “CCR5 antagonist TD-0680 uses a novel mechanism for enhanced potency against HIV-1 entry, cell-mediated infection and a resistant variant”, Journal of Biological Chemistry Vol. 287, pp. 16499-16509 (2012)
  • Chan, M.C.W., Lee, N., Ho, W.S., Law, C.O.K., Lau, T.C.K., Tsui, S.K.W. and Sung, J.J.Y. “Co-variation of Major and Minor Viral Capsid Proteins in Norovirus Genogroup II Genotype 4 Strains”, Journal of Virology, Vol. 86, pp. 1227-1232 (2012)
  • Lu, X., Liu, L., Zhang, X., Lau, T.C.K., Tsui, S.K.W., Kang, Y., Zheng, P., Liu, G. and Chen, Z. “F18, a novel small molecule NNRTI, inhibits HIV-1 replication using distinct binding motifs”, Antimicrobial Agents and Chemotherapy, Vol. 56, pp. 341-351 (2012)
  • Li, M.S.*, Lau, T.C.K.*, Chan, S.K.P., Wong, C.H., Ng, P.K.S., Sung, J.J.Y., Chan, H.L.Y., Tsui, S.K.W. “G1613A Mutation on HBV Core Promoter Suppresses e Antigen Secretion and Enhances Viral Replication”, Plos One, Vol. 6, pp. e21856 (2011) (*co-authors)
  • Kong, H.K., Chadbourne, F.L., Law, G.L., Li, H., Tam, H.L., Cobb, S.L., Lau, C.K.*, Lee, C.S.*, Wong, K.L.* “Responsive Two-Photon Induced f-f Emissive Detection for Cyclin A with Europium-Chelating Peptide”, Chemical Communications, Vol. 47, pp. 8052-8054 (2011) (*co-corresponding authors)
  • Tsoi, H., Lau, C.K., Lau, K.F. and Chan, H.Y.E. “Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ disease”, Human Molecular Genetics, Vol. 20, pp. 3787-3797 (2011)
  • Fung, Y.O., Wu, W., Yeung, C.T., Kong, H.K., Wong, K.K.C., Lo, S.W.S., Law, G.L., Wong, K.L., Lau, T.C.K., Lee, C.S., Wong, W.T. “Responsive Dimeric Lanthanide DO3A Complex for Protein Staining and In-Vitro Imaging”, Inorganic Chemistry, Vol. 50, pp. 5517-5525 (2011)
  • Siu, G.K.H., Zhang, Y., Lau, T.C.K., Lau, R.W.T., Ho, P.L., Yew, W.W., Tsui, S.K.W., Cheng, V.C.C., Yuen, K.Y. and Yam, W.C. “Novel mutations outside rifampicin resistance determining region associated with rifampicin resistance in Mycobacterium tuberculosis”, The Journal of Antimicrobial Chemotherapy, Vol. 66, pp. 730-733 (2011)
  • Chan, T.M., Wong, K.C., Lee, K.H., Wong, M.H., Lau, C.K., Tsui, S.K.W., Leung, K.S. “Discovering approximate associated sequence patterns for protein-DNA interactions”, Bioinformatics, Vol. 27, pp. 471-478 (2011)
  • Lau, C.K., Hui, J., Fong, F.N.Y., To, K.T., Fok, T.F., Tang, N.L.S., Tsui, S.K.W. “Novel mutations in PHKA2 gene in glycogen storage disease type IX patients from Hong Kong, China”,Molecular Genetics and Metabolism, Vol. 102, pp. 222-225 (2010)
  • Lau, R.W.T., Ho, P.L., Kao, R.Y.T., Yew, W.W., Lau, T.C.K., Cheng, V.C.C., Yuen, K.Y., Tsui, S.K.W., Chen, X. and Yam, W.C. “Molecular Characterization of Fluoroquinolone Resistance in Mycobacterium tuberculosis: Functional Analysis of DNA Gyrase Harboring Mutation at Position 74 of gyrA”, Antimicrobial Agents and Chemotherapy, Vol. 55, pp. 608-614 (2010)
  • Leung, K.S., Wong, K.C., Chan, T.M., Wong, M.H. Lee, K.H., Lau, C.K., Tsui, S.K.W. “Discovering Protein-DNA binding sequence patterns using association rule mining”, Nucleic Acids Research, Vol. 38, pp. 6324-6337 (2010)
  • Sabin, L. R., Zhou, R., Gruber, J.J., Lukinova, N., Bambina, S., Berman, A., Lau, C.K., Thompson, C.B. and Cherry, S. “Ars2 regulates both miRNA- and siRNA-dependent silencing and suppresses RNA virus infection in Drosophila”, Cell, Vol. 138, pp. 340-351 (2009)
  • Gruber, J.J., Zatechka, D.S., Sabin, L.R., Yong, J., Lum, J.J., Kong, M., Zong, W.X., Zhang, Z., Lau, C.K., Rawlings, J., Cherry, S., Ihle, J.N., Dreyfuss, G., Thompson, C.B. “Ars2 links the nuclear cap binding complex to RNA interference and cell proliferation”, Cell, Vol. 138, pp. 328-339 (2009)
  • Lau, C.K., Bachorik, J. and Dreyfuss, G. “Gemin5-snRNA interaction reveals a novel RNA-binding function for WD-repeat domains”, Nature Structural and Molecular Biology, Vol. 16, pp. 486-491 (2009)
  • Battle, D.J., Lau, C.K., Wan, L. and Dreyfuss, G. “Gemin5 is the RNA binding protein of the SMN complex and the snRNA specificity-determining factor”, Molecular Cell, Vol. 23, pp. 273-279 (2006)
  • Ghosh, K., Lau, C.K., Gupta, K., and Van Duyne, G.D. “Preferential synapsis of loxP sites drives ordered strand exchange in Cre-loxP site-specific recombination”, Nature Chemical Biology, Vol. 1, pp. 275-282 (2005)
  • Ghosh, K., Lau, C.K., Guo, F., Segall, A., and Van Duyne, G.D. “Peptide trapping of the Holliday junction intermediate in Cre-loxP site-specific recombination”, Journal of Biological Chemistry, Vol. 280, pp. 8290-8299 (2005)
  • Lau, C.K., Diem, M.D., Dreyfuss, G., Van Duyne, G.D. “Structure of the Y14-magoh core of the Exon junction complex”, Current Biology, Vol. 13, pp.933-941 (2003)

Book Chapters

  • Battle, D.J., Kasim, M., Yong, J., Lotti, F., Lau, C.K., Mouaikel, J., Zhang, Z., Han, K., Wan, L. and Dreyfuss, G. “The SMN Complex: An Assembly Machine for RNPs” In Cold Spring Habor Symposia On Quantitative Biology, Vol. LXXL (2007)