Prof. Shuk Han Cheng (鄭淑嫻教授)

PhD (London)

Chair Professor of Molecular Medicine
Associate Dean (Learning & Teaching) of Jockey Club College of Veterinary Medicine and Life Sciences (JCC)

Prof. Shuk Han Cheng

Contact Information

Office: 1B-207, 2/F, Block 1,
To Yuen Building
Phone: +852 3442-9027
Fax: +852 3442-0549
Email: bhcheng@cityu.edu.hk
Web: Personal Homepage
CityU Scholars

Research Interests

Nature or nurture: molecular and chemical regulation of vertebrate embryonic development and adult organ regeneration

Prof. Shuk Han Cheng received her BSc (Hons) from the University of Hong Kong, majoring in Zoology. She received her PhD from the Royal Postgraduate Medical School, which is now part of the Imperial College, University of London. Her PhD work was on the cellular immune response of BCG vaccination, under the supervision of Prof. Denny Mitchison in the Department of Bacteriology, Hammersmith Hospital. She did postdoctoral training under the supervision of Prof. Tak Mak on molecular immune response of T cells, at the Ontario Cancer Institute in Toronto. Before joining CityU in 1997, she worked in the Departments of Paediatrics, and Orthopaedics and Traumatology, at The Chinese University of Hong Kong.

She has won many innovation awards at international exhibitions, including Grand Prix and Gold Medal as a co-inventor for the invention “in vivo testing without animal experimentation” at the 43rd International Exhibition of Inventions in 2015 and WIPO Medal for Inventors, “A World-leading Non-animal in Vivo Testing Method” presented by World Intellectual Property Organization at the 8th International Invention Fair in 2015. In addition, she has been awarded the Gold Medal at the 35th International Exhibition of Inventions, New Techniques and Products of Geneva in 2007, 2 gold awards from the Korean International Women’s invention Expositions in 2009 and 2010, Gold Award and also a Special Prize from the Patent Office of the Republic of Poland, for the invention of “Rapid-identification Kit for Meat Ingredients in Processed Food” and a Bronze Award for the invention “Transgenic fish for high-throughput biomonitoring of Toxicants” in 2011. She is the recipient of the 2015 CityU Outstanding Research Award.

She has published over 140 peer-reviewed research articles and some of them are among the Top 25 Hottest Articles in the Science Direct database. Her H-factor is 32. To date she has supervised 23 graduate students, with 9 awarded PhD and another 9 awarded MPhil. She has also supervised 16 postdoctoral fellows. She is a member of the Advisory Committee on Admission of Quality Migrants and Professional; Enterprise Support Scheme (ESS) Assessment Panel of Innovation and Technology Commission, Research Project Vetting Subcommittee; Editorial Board of the journal Nanomedicine: Nanotechnology, Biology and Medicine. She is an overseas Fellow of the Royal Society of Medicine (London). She also serves on the Board of Directors of Nano and Advanced Materials Institute Limited (NAMI) in Hong Kong, and acts as the vice-chair of the Technical Committee in NAMI.

She takes great interest in teaching and mentoring undergrad students. She teaches the BSc course “Technology for Regenerative Medicine” and also coaches non-Biology major students on using biotechnology in business plans for entrepreneur competitions. She is on the Scientific Advisory Board of the Biotechnology company Vitargent.

She also holds the concurrent appointment as Chair Professor of Molecular Medicine in the Department of Biomedical Sciences and as the Associate Dean (Learning & Teaching) in the Jockey Club College of Veterinary Medicine and Life Sciences (JCC).

Research Projects

The primary focus of the Cheng lab is to investigate how molecules and chemicals interact in regulating the fascinating processes of embryonic development and adult organ regeneration. Specifically, we investigate the functions of a family of transcription factors, encoded by the Iroquois homeobox genes, in patterning and specifying the development and functions of the heart and retina. Using the transparent zebrafish embryos as our model organism, we develop computational tools to augment and quantify bio-imaging data of gene expression domains and biodistribution of novel chemicals and nanomedicine. We also adapt the Electrocardiogram (ECG) to measure electric conductance and charges in the 2 mm long zebrafish embryos. Our unique capacity to combine bio-imaging and electrophysiology enables us to correlate different parameters of the cardiovascular anatomy and physiology to altered gene expression or to exposure to chemicals, such as toxicants and drugs. Expanding from this set of tools, we are synthesizing and testing nanomedicine which can over come cancer drug resistance or exert anti-angiogenic actions. The zebrafish is also an amazing model of adult heart regeneration. We are currently using an interdisciplinary approach to extend this animal model for the development of novel cell- or nanomaterial-based therapeutics applicable for regenerative medicine. In collaboration with chemist, robotics engineer and nanomaterial scientist, we use emerging technologies to harvest and modify regenerating heart cells. Our long-term goal is to translate the zebrafish work back to mammals and contribute to the understanding and achievement of organ regeneration.

Publications

  1. Manno, S. H. C., Manno, F. A. M., Ahmed, I., Ahmed, R., Shu, L., Li, L., Xu, S., Xie, F., Li, V. W., Ho, J., Cheng, S. H. & Lau, C. (2018) Spectroscopic examination of enamel staining by coffee indicates dentin erosion by sequestration of elements Talanta. 189, p. 550-559
  2. Manno, F. A. M., Lively, M. B., Manno, S. H. C., Cheng, S. H. & Lau, C. (2018) Health risk communication message comprehension is influenced by image inclusion, Journal of Visual Communication in Medicine.
  3. Li, J., Li, X., Luo, T., Wang, R., Liu, C., Chen, S., Li, D., Yue, J., Cheng, S. & Sun, D. (2018) Development of a magnetic microrobot for carrying and delivering targeted cells, Science Robotics. 3, 19, eaat8829
  4. Li, X., Chen, S., Liu, C., Cheng, S. H., Wang, Y. & Sun, D. (2018) Development of a collision-avoidance vector based control algorithm for automated in-vivo transportation of biological cells, Automatica. 90, p. 147-156
  5. Kong, E. Y., Cheng, S. H. & Yu, K. N. (2018) Induction of autophagy and interleukin 6 secretion in bystander cells: metabolic cooperation for radiation-induced rescue effect? Journal of Radiation Research. 59, 2, p. 129-140
  6. Xu, S., Webb, S. E., Lau, T. C. K. & Cheng, S. H. (2018) Matrix metalloproteinases (MMPs) mediate leukocyte recruitment during the inflammatory phase of zebrafish heart regeneration, Scientific Reports. 8, 1, 7199
  7. Li, L., Liu, C. C., Chen, X., Xu, S., Cortes-Manno, S. H. & Cheng, S. H. (2017) Mechanistic Study of Bakuchiol-Induced Anti-breast Cancer Stem Cell and in Vivo Anti-metastasis Effects, Frontiers in Pharmacology. 8, 746
  8. Li, X., Liu, C., Chen, S., Wang, Y., Cheng, S. H. & Sun, D. (2017) In Vivo Manipulation of Single Biological Cells With an Optical Tweezers-Based Manipulator and a Disturbance Compensation Controller, IEEE Transactions on Robotics. 33, 5, p. 1200-1212 7976371
  9. Ng, C. Y. P., Cheng, S. H. & Yu, K. N. (2017) Photon hormesis deactivates alpha-particle induced bystander effects between zebrafish embryos, Radiation Physics and Chemistry. 133, p. 72-80
  10. Ding, J., Lu, Y., Fu, L., Ding, Z., Mu, Y., Cheng, S. H. & Zeng, R. J. (2017) Decoupling of DAMO archaea from DAMO bacteria in a methane-driven microbial fuel cell, Water Research. 110, p. 112-119
  11. Chiu, P. H. P. & Cheng, S. H. (2017) Effects of active learning classrooms on student learning: a two-year empirical investigation on student perceptions and academic performance, Higher Education Research and Development. 36, 2, p. 269-279
  12. Ng, C. Y. P., Cheng, S. H. & Yu, K. N. (2017) Effect of photon hormesis on dose responses to alpha particles in zebrafish embryos, International Journal of Molecular Sciences. 18, 2, 385
  13. Mak, Y. L., Li, J., Liu, C., Cheng, S. H., Lam, P. K., Cheng, J. & Chan, L. L. (2017) Physiological and behavioural impacts of Pacific ciguatoxin-1 (P-CTX-1) on marine medaka (Oryzias melastigma), Journal of Hazardous Materials. 321, p. 782-790
  14. Kong, E. Y., Cheng, S. H. & Yu, K. N. (2016) Zebrafish as an in vivo model to assess epigenetic effects of ionizing radiation, International Journal of Molecular Sciences. 17, 12, 2108
  15. Chiu, P. H. P., Fan, F., Im, S. W. T., Cheng, S. H., Chui, L. L. S., Li, L. & Liu, D. Y. W. (2016) A project-problem based learning approach for appreciating ancient cultural heritage through technologies: Realizing mystical buildings in Dunhuang Mural, Proceedings of 2016 IEEE International Conference on Teaching, Assessment and Learning for Engineering (TALE). Institute of Electrical and Electronics Engineers Inc., p. 65-69 7851772
  16. Li, X., Liu, C., Chen, S., Wang, Y., Cheng, S. H. & Sun, D. (2016) Automated in-vivo transportation of biological cells with a disturbance compensation controller, IEEE International Conference on Intelligent Robots and Systems. Institute of Electrical and Electronics Engineers Inc., Vol. 2016-November, p. 2561-2566
  17. Yang, C., Li, V. W., Yu, P. K., Cheng, S. H. & Lam, R. H. (2016) Measurement of alpha radiation based on amperometric activity of bacteria focused electrokinectically in microfluidics, 2016 IEEE 10th International Conference on Nano/Molecular Medicine and Engineering (NANOMED). IEEE, p. 93-96 7883573
  18. Cheng, J., Gu, Y.-J., Man, C. W.-Y., Wong, W.-T. and Cheng, S. H. (2017) Gold–Doxorubicin Nanoconjugates for Overcoming Multidrug Resistance. In L. P. Balogh (Ed.), Nanomedicine in Cancer p597-622, Singapore: Pan Stanford.
  19. Ng, C. Y. P., Cheng, S. H. and Yu, K. N. (2017) Photon hormesis deactivates alpha-particle induced bystander effects between zebrafish embryos. Radiation Physics and Chemistry 133: 72-80. doi: 10.1016/j.radphyschem.2016.12.025
  20. Ding, J., Lu, Y.-Z., Fu, L., Ding, Z.-W., Mu, Y., Cheng, S. H. and Zeng, R. J. (2017) Decoupling of DAMO archaea from DAMO bacteria in a methane-driven microbial fuel cell. Water Research 110: 112-119. doi: 10.1016/j.watres.2016.12.006
  21. Ng, C. Y. P., Cheng, S. H. and Yu, K. N. (2017) Effect of Photon Hormesis on Dose Responses to Alpha Particles in Zebrafish Embryos. International Journal of Molecular Sciences 18(2): 385. doi: 10.3390/ijms18020385
  22. Mak, Y. L., Li, J., Liu, C-N., Cheng, S. H., Lam, P. K. S., Cheng, J. and Chan, L. L. (2017) Physiological and behavioural impacts of Pacific ciguatoxin-1 (P-CTX-1) on marine medaka (Oryzias melastigma). Journal of Hazardous Materials 321: 782-790. doi: 10.1016/j.jhazmat.2016.09.066
  23. Kong, E. Y., Cheng, S. H. and Yu, K. N. (2016) Zebrafish as an In Vivo Model to Assess Epigenetic Effects of Ionizing Radiation. International Journal of Molecular Sciences 17(12): 2108. doi: 10.3390/ijms17122108
  24. Kong, E. Y., Yeung, W. K., Chan, T. K. Y., Cheng, S. H. and Yu, K. N. (2016) Exogenous Nitric Oxide Suppresses in Vivo X-ray-Induced Targeted and Non-Targeted Effects in Zebrafish Embryos. International Journal of Molecular Sciences 17(8):1321. doi: 10.3390/ijms17081321
  25. Chow, Y. T., Chen, S., Liu, C., Liu, C., Li, L., Kong, C. W. M., Cheng, S. H., Li, R. A. and Sun, D. (2016) A high-throughput automated microinjection system for human cells with small size. IEEE/ASME Transactions on Mechatronics 21(2): 838-850. doi: 10.1109/TMECH.2015.2476362
  26. Li, L., Chen, X., Liu, C. C., Lee, L. S., Man, C. and Cheng, S. H. (2016) Phytoestrogen bakuchiol exhibits in vitro and in vivo anti-breast cancer effects by inducing S phase arrest and apoptosis. Frontiers in Pharmacology 7:128. doi: 10.3389/fphar.2016.00128
  27. Chiu, P. H. P. and Cheng, S. H. (2016) Effects of active learning classrooms on student learning: a two-year empirical investigation on student perceptions and academic performance. Higher Education Research & Development 36(2): 269-279. doi: 10.1080/07294360.2016.1196475
  28. Ding, J., Fu, L., Ding, Z.-W., Lu, Y.-Z., Cheng, S.H. and Zeng, R. J. (2016) Environmental evaluation of coexistence of denitrifying anaerobic methane-oxidizing archaea and bacteria in a paddy field. Applied Microbiology and Biotechnology 100(1): 439-446. doi: 10.1007/s00253-015-6986-2
  29. Wang, R., Chen, S., Li, C., Ng, K. T. P., Kong, C.-W., Cheng, J., Cheng, S.H.. Li, R. A., Lo, C. M., Man, K. and Sun, D. (2016) Fusion with stem cell makes the hepatocellular carcinoma cells similar to liver tumor-initiating cells. BMC Cancer 16:56. doi: 10.1186/s12885-016-2094-7
  30. Li, V. W. T., Tsui, M. P. M., Chen, X., Hui, M. N. Y., Lam, R. H. W., Yu, R. M. K, Murphy, M. B., Cheng, J., Lam, P. K. S. and Cheng, S. H. (2016) Effects of 4-methylbenzylidene camphor (4-MBC) on neuronal and muscular development in zebrafish (Danio rerio) embryos. Environmental Science and Pollution Research 23(9): 8275-8285. doi: 10.1007/s11356-016-6180-9
  31. Ding, J., Fu, L., Ding, Z.-W., Lu, Y.-Z., Cheng, S.H. and Zeng, R.J. (2016) Experimental evaluation of the metabolic reversibility of ANME-2d between anaerobic methane oxidation and methanogenesis. Applied Microbiology and Biotechnology 100(14): 6481-6490. doi: 10.1007/s00253-016-7475-y
  32. Liu, C. C., Li, L., Lam, Y. W., Siu, C. W. and Cheng, S. H. (2016) Improvement of surface ECG recording in adult zebrafish reveals that the value of this model exceeds our expectation. Scientific Reports 6: 25073. doi: 10.1038/srep25073
  33. Ng, C. Y., Pereira, S., Cheng, S. H., Adam-Guillermin, C., Garnier-Laplace, J. and Yu, K. N. (2016) Combined effects of alpha particles and depleted uranium on Zebrafish (Danio rerio) embryos. Journal of Radiation Research 57(4): 343-355. doi: 10.1093/jrr/rrv104
  34. Ng, C. Y., Kong, E. Y., Kobayashi, A., Suya, N., Uchihori, Y., Cheng, S. H., Konishi, T. and Yu, K. N. (2016) Non-induction of radioadaptive response in zebrafish embryos by neutrons. Journal of Radiation Research 57(3): 210-219. doi: 10.1093/jrr/rrv089
  35. Kong, E. Y., Cheng, S. H. and Yu, K. N. (2016) Biphasic and triphasic dose responses in zebrafish embryos to low-dose 150 kV X-rays with different levels of hardness. Journal of Radiation Research, 57(4): 363-369. doi: 10.1093/jrr/rrw026
  36. Ng, C. Y., Cheng, S. H. and Yu, K. N. (2016) Hormetic effect induced by depleted uranium in zebrafish embryos. Aquat Toxicology 175:184-191. doi: 10.1016/j.aquatox.2016.03.020
  37. Babaei, F., Hong, T. L. C., Yeung, K., Cheng, S. H. and Lam, Y. W. (2016) Contrast-Enhanced X-ray Micro-Computed Tomography as a Versatile Method for Anatomical Studies of Adult Zebrafish. Zebrafish 13(4): 310-316. doi: 10.1089/zeb.2016.1245
  38. Chow, Y. T., Chen, S., Wang, R., Liu, C., Kong, C. W., Li, R. A., Cheng, S. H. and Sun, D. (2016) Single Cell Transfection through Precise Microinjection with quantitatively Controlled Injection Volumes. Scientific Reports 6: 24127. doi: 10.1038/srep24127
  39. Lin, X., Li, V. W. T., Chen, S., Chan, C.-Y., Cheng, S. H. and Shi, P. (2016) Autonomous system for cross-organ investigation of ethanol-induced acute response in behaving larval zebrafish. Biomicrofluidics 10(2): 024123. doi: 10.1063/1.4946013
  40. Ng, C. Y. P., Kong, E. Y., Kobayashi, A., Suya, N., Uchihori, Y., Cheng, S. H., Konishi, T. and Yu, K. N. (2015) Neutron induced bystander effect among zebrafish embryos. Radiation Physics and Chemistry 117: 153-159. doi: 10.1016/j.radphyschem.2015.08.009
  41. Ng, C. Y. P., Kong, E. Y., Konishi, T., Kobayashi, A., Suya, N., Cheng, S. H. and Yu, K. N. (2015) Low-dose neutron dose response of zebrafish embryos obtained from the Neutron exposure Accelerator System for Biological Effect Experiments (NASBEE) facility. Radiation Physics and Chemistry, 114: 12-17. doi: 10.1016/j.radphyschem.2015.05.020
  42. Cheng, S. H., Ng, C.Y.P., Pereira, S., Adam-Guillermi,n C., Garnier-Laplace, J. and Yu, K. N. (2015) Combined Effects of Depleted Uranium and Ionising Radiation on Zebrafish Embryos. Radiation Protection Dosimetry NCV269.
  43. Cheng, S. H., Lam, R. K. K., Fung, Y. K., Han, W., Li, L., Chiu, S. K. and Yu, K. N. (2015) Modulation of NF-κB in rescued irradiated cells. Radiation Protection Dosimetry NCV217.
  44. Tang, T. S., Leung, K. K., Louie, M. W., Liu, H., Cheng, S. H. and *Lo, K. W. K. (2015) Phosphorescent biscyclometallated iridium(III) ethylenediamine complexes functionalised with polar ester or carboxylate groups as bioimaging and visualisation reagents. Dalton Transactions 44(11): 4945-4956 doi: 10.1039/c4dt02890b.
  45. Lin, X., Wang, S., Yu, X., Liu, Z., Wang, F., Li, W. T. V., Cheng, S. H., Dai, Q. and Shi, P. (2015) High-throughput mapping of brain-wide activity in awake and drug-responsive vertebrates. Lab on a Chip 15(3):680-689 doi: 10.1039/c4lc01186d.
  46. Kong, E. Y., Choi, V. W. Y., Cheng, S. H. and *Yu, P. K. N. (2014) Some properties of the signals involved in unirradiated zebrafish embryos rescuing α-particle irradiated zebrafish embryos, International Journal of Radiation Biology 90(12):1133-1142 doi: 10.3109/09553002.2014.932031.
  47. Kwan, K. H. L., Yeung, K. W. K., Liu, X., Wong, K. K. Y., Shum, H. O., Lam, Y. W., Cheng, S. H., Cheung, K. M. C., and *To, M. K. T. (2014) Silver nanoparticles alter proteoglycan expression in the promotion of tendon repair. Nanomedicine: Nanotechnology, Biology and Medicine 10:1375-1383.
  48. Choi, V. W. Y., Ng, C. Y. P., Kobayashi, A., Konishi, T., Oikawa, M., Cheng, S. H. and *Yu, P. K. N. 2014. Exogenous carbon monoxide suppresses adaptive response induced in zebrafish embryos in vivo by microbeam protons. Journal of Radiation Research, 2014, 55, i115.
  49. Choi, V. W. Y., Ng, C. Y. P., Kobayashi, A., Konishi, T., Oikawa, M., Cheng, S. H. and *Yu, P. K. N. 2014. Roles of nitric oxide in adaptive response induced in zebrafish embryos in vivo by microbeam protons. Journal of Radiation Research, 2014, 55, i114.
  50. Choi, V. W. Y., Ng, C. Y. P., Kobayashi, A., Konishi, T., Oikawa, M., Cheng, S. H. and *Yu, P. K. N. 2014. Response of 5 hpf zebrafish embryos to low-dose microbeam protons. Journal of Radiation Research, 2014, 55, i113.
  51. *Chen X.,  Xu S.,  Tan T.,  Lee S. T.,  Cheng, S. H.,  Lee F. W. F.,  Xu S. J. L. and Ho K. C. (2014) Toxicity and Estrogenic Endocrine Disrupting Activity of Phthalates and Mixtures. Int. J. Environ Res Public Health 11(3), 3156-3168.
  52. *Chan, B. P., MA, J., XU, J., LI, C., Cheng, J., and Cheng, S. H. (2014) Femto-second laser-based free writing of 3D protein microstructures and micropatterns with sub-micron features - A study on voxels, porosity and cytocompatibility. Advanced Functional Materials 24, 277-294.
  53. Tian, L., Cheng, J., Chen, X., Cheng, S. H., Cheng, Y. L. M., Lam, P. K. S., Chan, L. L. and Wang, M. (2014) Early developmental toxicity of saxiton on medaka (Oryzias melastigma) embryos. Toxicon, 77c, 16-25.
  54. Lin, C. C., Fung, L. L., Chan, P. K., Lee, C. M., Chow, K. F., and *Cheng, S. H. (2014). A rapid low-cost high-density DNA-based multi-detection test for routine inspection of meat species. Meat Science, 96(2), 922-929.
    Work described in this article has been awarded the Gold Award and also a Special Prize from the Patent Office of the Republic of Poland, for the 30invention of “Rapid-identification Kit for Meat Ingredients in Processed Fo31od” on 4-7 May, 2011
  55. Wang, B., Luo, P.G., Tackett, K.N., Ruiz, O.N., Bunker, C.E., Cheng, S.H., Parenzan, A. and *Sun, Y.P. (2013). Graphene oxide as a substrate for enhanced mammalian cell growth. J Nanomaterials and Molecular Nanotechnology, doi:10.4172/2324-8777.1000102.
  56. Li, S. P. Y., Lau, C. T. S., Louie, M. W., *Lam, Y. W., *Cheng, S. H., and *Lo, K. K. W. (2013). Mitochondria-targeting cyclometalated iridium (III)–PEG complexes with tunable photodynamic activity. Biomaterials, 34(30), 7519-7532.
  57. Wong, H. M., Wu, S., Chu, P. K., Cheng, S. H., Luk, K. D., Cheung, K., and *Yeung, K. W. (2013). Low-modulus Mg/PCL hybrid bone substitute for osteoporotic fracture fixation. Biomaterials, 34(29), 7016-7032.
  58. Wang, K., Cheng, J., Cheng, S. H., Li, R. A. and *Sun, D. (2013) Probing cell biophysical behavior based on actin cytoskeleton modeling and optical tweezers stretching manipulation. Applied Physics Letters, 103(8), 083706
  59. Cheng, J., Gu, Y. J., *Cheng, S. H., and *Wong, W. T. (2013). Surface Functionalized Gold Nanoparticles for Drug Delivery. Journal of biomedical nanotechnology, 9(8), 1362-1369.
  60. Dong, H., Cheung, S. H., Liang, Y., Wang, B., Ramalingam, R., Wang, P., Sun, H., Cheng, S. H., and *Lam, Y. W. (2013). “Stain-omics”: Identification of mitotracker labeled proteins in mammalian cells. Electrophoresis, 34(13), 1957-1964.
  61. Chen, S., Cheng, J., Kong, C. W., Wang, X., Cheng, S. H., Li, R. A., and *Sun, D. (2013). Laser-induced fusion of human embryonic stem cells with optical tweezers. Applied Physics Letters, 103(3), 033701-033701.
  62. Cai, X., Ramalingam, R., Wong, H. S., Cheng, J., Ajuh, P., *Cheng, S. H., and *Lam, Y. W. (2013). Characterization of carbon nanotube protein corona by using quantitative proteomics. Nanomedicine: Nanotechnology, Biology and Medicine,9(5), 583-593.
  63. Choi, V. W. Y., Ng, C. Y. P., Kobayashi, A., Konishi, T., Suya, N., Ishikawa, T., Cheng, S. H., and *Yu, P. K. N. (2013). Bystander Effect between Zebrafish Embryos in Vivo Induced by High-Dose X-rays. Environmental science & technology, 47(12), 6368-6376.
  64. Shi, Y., Liu, X., Zhu, .P, L,i J., Sham, K.W.Y., Cheng, S. H., Li, S., Zhang, Y., *Cheng, C.H.K. and * Lin H. (2013). G-protein-coupled estrogen receptor 1 is involved in brain development during zebrafish (Danio rerio) embryogenesis. Biochemical and Biophysical Research Communications 435, 21-27.
  65. Babaei, F., Ramalingam, R., Tavendale, A., Liang, Y., Yan, L. S. K., Ajuh, P., Cheng, S. H., and *Lam, Y. W. (2013). Novel Blood Collection Method Allows Plasma Proteome Analysis from Single Zebrafish. Journal of proteome research, 12(4), 1580-1590.
  66. Ng, C. Y. P., Choi, V. W. Y., Lam, A. C. L., Cheng, S. H., and *Yu, K. N. (2013). The multiple stressor effect in zebrafish embryos from simultaneous exposure to ionising radiation and cadmium. Journal of Radiological Protection, 33(1), 113.
  67. Deng, Z. L., Dong, J. W., Wang, H. Z., Cheng, S. H., and *Li, J. (2013). Power transmission and group delay in gain-assisted plasmon-induced transparency. AIP Advances, 3(3), 032138-032138.
  68. Choi, V. W. Y., Ng, C. Y. P., Kong, M. K. Y., Cheng, S. H., and *Yu, K. N. (2013). Adaptive response to ionising radiation induced by cadmium in zebrafish embryos. Journal of Radiological Protection, 33(1), 101.
  69. Choi, V. W. Y., Konishi, T., Oikawa, M., Cheng, S. H., and *Yu, K. N. (2013). The threshold number of protons to induce an adaptive response in zebrafish embryos. Journal of Radiological Protection, 33(1), 91.
  70. Wang, B., Liang, Y., Dong, H., Tan, T., Zhan, B., Cheng, J., *Lo, K. K., *Lam, Y. W., and *Cheng, S. H. (2012). A Luminescent Cyclometalated Iridium (III) Complex Accumulates in Mitochondria and Induces Mitochondrial Shortening by Conjugation to Specific Protein Targets. ChemBioChem, 13(18), 2729-2737.
  71. Choi, A. W. T., Louie, M. W., Li, S. P. Y., Liu, H. W., Chan, B. T. N., Lam, T. C. Y., Lin, A. L. L., *Cheng, S. H., and *Lo, K. K. W. (2012). Emissive Behavior, Cytotoxic Activity, Cellular Uptake, and PEGylation Properties of New Luminescent Rhenium (I) Polypyridine Poly (ethylene glycol) Complexes. Inorganic chemistry, 51(24), 13289-13302.
  72. *Yu, K. N., Tung, M. M. T., Choi, V. W. Y., and Cheng, S. H. (2012). Alpha radiation exposure decreases apoptotic cells in zebrafish embryos subsequently exposed to the chemical stressor, Cd. Environmental Science and Pollution Research, 19(9), 3831-3839.
  73. Tong, W. Y., Shen, W., Yeung, C. W., Zhao, Y., Cheng, S. H., Chu, P. K., Chan, D., Chan, G. C. F., Cheung, K. M. C., Yeung, K. W. K., and *Lam, Y. W. (2012). Functional replication of the tendon tissue microenvironment by a bioimprinted substrate and the support of tenocytic differentiation of mesenchymal stem cells. Biomaterials, 33(31), 7686-7698.
  74. Choi, V. W. Y., Cheung, A. L. Y., Cheng, S. H., and *Yu, K. N. (2012). Hormetic effect induced by alpha-particle-induced stress communicated in vivo between zebrafish embryos. Environmental science & technology, 46(21), 11678-11683.
  75. Finn, J., Hui, M., Li, V., Lorenzi, V., de la Paz, N., Cheng, S. H., Chan, L. L., and *Schlenk, D. (2012). Effects of Propranolol on Heart Rate and Development in Japanese Medaka (Oryzias latipes) and Zebrafish (Danio rerio). Aquatic Toxicology, 122,214-221.
  76. Yu, R. M. K., Chu, D. L. H., Tan, T. F., Li, V. W. T., Chan, A. K. Y., Giesy, J. P., Cheng, S. H., Wu, R. S. S., and *Kong, R. Y. C. (2012). Leptin-mediated modulation of steroidogenic gene expression in hypoxic zebrafish embryos: Implications for the disruption of sex steroids. Environmental science & technology, 46(16), 9112-9119.
  77. Choi, V. W. Y., Wong, M. Y. P., Cheng, S. H., and *Yu, K. N. (2012). Effects of exogenous carbon monoxide on radiation-induced bystander effect in zebrafish embryos in vivo. Applied Radiation and Isotopes, 70(7), 1075-1079.
  78. Ng, C. K. M., Tjhin, V. T., Lin, A. C. C., Cheng, J. P., Cheng, S. H., and *Yu, K. N. (2012). Fabrication of substrates with curvature for cell cultivation by alpha-particle irradiation and chemical etching of PADC films. Nuclear Instruments and Methods in Physics Research (Section B), 278, 15-19.
  79. Choi, V. W. Y., Yum, E. H. W., Konishi, T., Oikawa, M., Cheng, S. H., and Yu, K. N. (2012). Triphasic low-dose response in zebrafish embryos irradiated by microbeam protons. Journal of Radiation Research, 53(3), 475-481.
  80. Gu, Y. J., Cheng, J., Man, C. W. Y., Wong, W. T., and *Cheng, S. H. (2012). Gold-doxorubicin nanoconjugates for overcoming multidrug resistance. Nanomedicine: Nanotechnology, Biology and Medicine, 8(2), 204-211.
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