Dr K. M. CHAN graduated with BSc and received his PhD at the department of Biochemistry, HKU. He then moved to Mayo Clinic (Rochester MN, USA) for postdoctoral training and obtained the Edward C. Kendall Research Fellowship in Biochemistry before rejoining HKU as Research Assistant Professor in June 2013. In February 2015 he joined the Department of Biomedical Sciences (BMS), City University of Hong Kong as a tenure-track Assistant Professor.
Dr Chan is interested in understanding 1) how epigenetic information is maintained during cell division and 2) the role of epigenetics in regulating gene expression and human diseases. It is well known that genetic information is encoded by the DNA sequence. However, DNA alone does not account for the complexity of the mammalian genome. Chromatin, comprising DNA, core histone proteins, and other regulatory proteins, regulates gene expression and maintains genome stability. Recent studies using the next generation sequencing (NGS) technologies have identified for the first time mutations on histone genes in two pediatric brain cancers; diffuse intrinsic pontine gliomas (DIPG) and glioblastoma multiforme (GBM). Two recurrent somatic mutations (K27M and G34R/V) were identified in genes encoding the canonical histone H3.1 (HIST1H3B) and its variant H3.3 (H3F3A.) This revealed the important roles of histone modifications in human diseases and links epigenetic changes to tumorigenesis.
We are currently elucidating the functional significance of novel epigenetic protein factors in maintaining X Chromosome Inactivation as well as the roles of histone mutations in human diseases.
We are looking for Postdoctoral Fellows, Research Assistants and Postgraduate Students to join our newly established research team. Interested candidates please send your CV and a summary of past research experience to Dr Chan: (email: firstname.lastname@example.org)
- Applications are invited for Research Assistant I or II. Applicants with M.Phil. degree in Biological Science, Biochemistry or a related discipline; or a Bachelor's degree with at least 1 year lab work experience are welcome to apply.
- PhD positions are available. BSc or MSc students with passion in basic or applied biomedical research are encouraged to apply.
- Postdoctoral fellow positions are available upon enquiry. Please contact Dr Chan directly for further information.
- Liu H, Peng L, So J, Tsang KH, Chong CH, Mak PHS, Chan KM# & Chan SY# (2018) TSPYL2 Regulates the Expression of EZH2 Target Genes in Neurons. Molecular Neurobiology 2018 Jul 26. doi: 10.1007/s12035-018-1238-y (Accepted, #Co-corresponding author)
- An L, Li J, Dong C, Chen J, Yuan J, Chan KM, Yu C, Legube G, Stark J, Huen MS. (2018) RNA169 limits 53BP1 at DSBs to stimulate single-strand annealing repair. PNAS 2018 (Accepted)
- Li S, Xu Z, Xu J, Wang X, Yu C, Zheng P, Zho L, Gan H, Li L, Sharma S, Chabes A, Li D, Yang J, Chen Y, Wang S, Sun Y, Zheng S, Li J, Chen X, Han J, Chan KM, Qi Z, Feng J, Li Q. (2018) Rtt105 promotes DNA replication by functioning as an RPA chaperone. EMBO J 2018 (Accepted)
- Wan YCE, Liu J, Chan KM. (2018) Histone H3 mutations in cancer. Curr Pharmacol Rep 2018. doi.org/10.1007/s40495-018-0141-6 (Corresponding author)
- Stunnenberg HG; International Human Epigenome Consortium, Hirst M et al.,(2016) The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery. Cell 2016; 167: 1145-49
- Chan KM, Han G, Fang D, Gan H, Zhang Z. (2013) A lesson learned from the H3.3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo. Cell Cycle. 2013 Jul 10;12(16): 2546-52
- Chan KM, Fang D, Gan H, Hashizume R, Yu C, Schroeder M, Gupta N, Mueller S, James CD, Jenkins R, Sarkaria J, Zhang Z. (2013) The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes & Dev. 2013. 27: 985-990
- Chan KM, Wong XHL, Jin GX, Liu BH, Cao R, Cao Y, Tryggvason K, Zhou ZJ. (2012) MT1-MMP Inactivates ADAM9 to Regulate FGFR Signaling and Calvarial Osteogenesis, Developmental Cell, 2012 Jun12 22,1176-90 Recommended by Faculty of 1000, F factor 8.0
- Chan KM, Zhang Z.(2012) Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing, J Biol Chem 2012 Apr27;287(18): 15024-33
- Chan KM, Zhang H, Malureanu L, van Deursen J, Zhang Z. (2011) Diverse factors are involved in maintaining X chromosome inactivation. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16699-704
- Qiu L, Hu X, Jing Q, Zeng X, Chan KM, Han J. (2018) Mechanism of cancer: Oncohistones in action. J Genet Genomics 2018 Apr30 doi.org/10.1016/j.jgg.2018.04.004
- Wong XHL, Cao R Jin GX, Chan KM, Cao Y, Zhou ZJ. (2012) When MT1-MMP meets ADAMs. Cell Cycle 11:15, Aug1,1-6
- Jin G, Zhang F, Chan KM, Xavier Wong HL, Liu B, Cheah KS, Liu X, Mauch C, Liu D, Zhou Z. (2011) MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development. EMBO J. 2011 Jun 1;30(11):2281-93. Epub 2011 May 13
- Sugiyama N, Varjosalo M, Meller P, Lohi J, Chan KM, Zhou Z, Alitalo K, Taipale J, Keski-Oja J, Lehti K. (2010) FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase -FGFR4 complex. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15786-91
- West MA, Prescott AR, Chan KM, Zhou Z, Rose-John S, Scheller J, Watts C. (2008) TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent. J Cell Biol. 2008 Sep 8;182(5):993-1005
- Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadiñanos J, López-Otín C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z. (2005) Genomic instability in laminopathy-based premature aging. Nat Med. 2005 Jul;11(7):780-5. Epub 2005 Jun 26
- Zhou Z, Wang J, Cao R, Morita H, Soininen R, Chan KM, Liu B, Cao Y, Tryggvason K. (2004) Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice. Cancer Res. 2004 Jul 15;64(14):4699-702.
- Zhou Z, Doi M, Wang J, Cao R, Liu B, Chan KM, Kortesmaa J, Sorokin L, Cao Y, Tryggvason K. (2004) Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice. Cancer Res. 2004 Jun 15;64(12):4059-63.
Honours and Awards
- Edward C. Kendall Research Fellowship in Biochemistry 2013, Mayo Clinic
- Professional Development Award 2015, City University of Hong Kong