Dr Chow received her bachelor’s degree in Biomedical Engineering from Duke University (Durham NC, USA). After two years of research in cancer genomics at Broad Institute and Dana-Farber Cancer Institute of Harvard and MIT (Boston MA, USA), she moved to University of California, Berkeley (Berkeley CA, USA) to pursue graduate studies in Molecular and Cell Biology. Her PhD research focused on gene regulation during B lymphocyte development and malignant transformation. With a Croucher Foundation Postdoctoral Fellowship and an NIH F32 National Research Service Award, Dr Chow conducted postdoctoral research at University of Washington (Seattle WA, USA) studying innate immune signaling and gene networks that regulate the anti-viral immune response. Dr Chow joined City University of Hong Kong in April 2018.
The Chow lab focuses on investigating what constitute a protective immune response against cancer in order to design effective cancer immunotherapy. The lab combines concepts and techniques from biochemistry, molecular and cell biology, cancer biology, immunology, virology, genomics, cell and animal models, and systems biology to dissect the molecular pathways and gene regulatory networks that modulate the anti-cancer immune response. The ultimate goal of the lab is to develop vaccines and targeted therapies that harness the natural ability of our immune system to fight cancer.
Current research themes include:
- Characterization of immune response in solid tumors
- Molecular mechanisms of effective anti-cancer immune response
- Design of cancer vaccines and adjuvants
We welcome talented and motivated individuals to join our team. Interested candidates please send a resume/CV and a research statement to Dr Chow (email@example.com).
- PhD students who have a strong interest in biomedical research are encouraged to apply through one of the following schemes:
* Candidates should have a strong academic record, good understanding of molecular and cell biology, relevant research experience, and high proficiency in English.
- the Hong Kong PhD Fellowship Scheme (link)
- PhD Programme in Biomedical Sciences (link)
- Interdisciplinary PhD Programme in Veterinary Science (in collaboration with Cornell University) (link)
- Undergraduate students who are interested in gaining lab experience are welcome to contact Dr Chow. Students pursuing degrees in Biological Sciences, Biomedical Sciences, Chemistry, or Biomedical Engineering who have taken introductory biology courses will be considered favorably.
- Research Assistant positions for individuals interested in pursuing a career in research science or lab management are welcome to contact Dr Chow. Candidates with previous research experience in molecular biology, tissue culture, or animal models are desired.
- Postdoctoral Fellow positions are available upon enquiry.
- Chow KT, Gale M Jr., Loo YM. RIG-I and Other RNA Sensors in Antiviral Immunity. Annu Rev Immunol. 2018 Apr 26;36:667-694. PubMed PMID: 29677479.
- Aarreberg LD, Wilkins C, Ramos HJ, Green R, Davis MA, Chow K, Gale M Jr. Interleukin-1β Signaling in Dendritic Cells Induces Antiviral Interferon Responses. MBio. 2018 Mar 20;9(2). PubMed PMID: 29559569.
- Chow KT, Gale M Jr. SnapShot: Interferon Signaling. Cell. 2015 Dec 17;163(7):1808-1808.e1. PubMed PMID: 26687364.
- Chow KT, Schulz D, McWhirter SM, Schlissel MS. Gfi1 and gfi1b repress rag transcription in plasmacytoid dendritic cells in vitro. PLoS One. 2013 Sep 24;8(9):e75891. PubMed PMID: 24086657.
- Chow KT, Timblin GA, McWhirter SM, Schlissel MS. MK5 activates Rag transcription via Foxo1 in developing B cells. J Exp Med. 2013 Jul 29;210(8):1621-34. PubMed PMID: 23878308.
- Banerji V, Frumm SM, Ross KN, Li LS, Schinzel AC, Hahn CK, Kakoza RM, Chow KT, Ross L, Alexe G, Tolliday N, Inguilizian H, Galinsky I, Stone RM, DeAngelo DJ, Roti G, Aster JC, Hahn WC, Kung AL, Stegmaier K. The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia. J Clin Invest. 2012 Mar;122(3):935-47. PubMed PMID: 22326953.
- Schulz D, Vassen L*, Chow KT*, McWhirter SM, Amin RH, Möröy T, Schlissel MS. Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1. J Exp Med. 2012 Jan 16;209(1):187-99. PubMed PMID: 22201127. (*equal contribution)
- Corsello SM, Roti G, Ross KN, Chow KT, Galinsky I, DeAngelo DJ, Stone RM, Kung AL, Golub TR, Stegmaier K. Identification of AML1-ETO modulators by chemical genomics. Blood. 2009 Jun 11;113(24):6193-205. PubMed PMID: 19377049.
- Stegmaier K, Wong JS, Ross KN, Chow KT, Peck D, Wright RD, Lessnick SL, Kung AL, Golub TR. Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma. PLoS Med. 2007 Apr;4(4):e122. PubMed PMID: 17425403.