|Office:||1B-109, 1/F, Block 1,
To Yuen Building
Dr Yan received his BSc (in biological sciences) at Tsinghua University and MSc (in biotechnology) at University of Helsinki. He continued his PhD study in Prof. Jussi Taipale’s lab at Karolinska Institutet, investigating molecular mechanism of transcriptional regulation in colorectal cancer cells. After obtaining PhD degree in 2014, Dr Yan moved to San Diego to study 3D genome organization and gene regulation as a postdoc fellow with Prof. Bing Ren at Ludwig Institute for Cancer Research. After more than a decade of biological research training in Asia, Europe and America, he joined the Department of Biomedical Sciences, as a tenure track assistant professor in the fall of 2018, focusing on function of sequence variants in development of complex human diseases using state-of-the-art genomics tools.
Due to high mutation burden in regulatory elements, affected cells develop aberrant gene transcription compared with surrounding normal cells that could device them with growth advantage. Some transcripts (including non-coding RNAs) have been used as clinical diagnostic markers for some cancer types whereas the molecular mechanism of their relevance to the cancer development remains largely elusive. Our research goal is to unveil molecular mechanism of how transcriptional aberration affects cancer development, using high throughput, state-of-the-art tools. My current interest focuses on developing genomic tools to:
We are seeking highly motivated talented researchers to join the lab as Research Assistants, Graduate Students and Postdoc Fellows all year round. Candidates with training background in either genomics, molecular biology, bioinformatics or mouse model are highly encouraged to apply. Should you be interested, please directly e-mail Dr Yan with your CV and contacts of three references.