Dr Jian Yan (嚴健博士)

PhD (Karolinska Institutet)

Assistant Professor

Dr Jian Yan

Contact Information

Office: 1B-109, 1/F, Block 1,
To Yuen Building
Phone: +852 3442-9078
Fax: +852 3442-0549
Email: jian.yan@cityu.edu.hk
Web: CityU Scholars

Research Interests

  • Molecular Mechanism of Osteosarcoma Tumorigenesis and Pulmonary Metastasis
  • lncRNA Function
  • Transcription Factor in Transcriptional Regulation
  • Genomic Tool Development

Dr Yan received his BSc (in biological sciences) at Tsinghua University and MSc (in biotechnology) at University of Helsinki. He continued his PhD study in Prof. Jussi Taipale’s lab at Karolinska Institutet, investigating molecular mechanism of transcriptional regulation in colorectal cancer cells. After obtaining PhD degree in 2014, Dr Yan moved to San Diego to study 3D genome organization and gene regulation as a postdoc fellow with Prof. Bing Ren at Ludwig Institute for Cancer Research. After more than a decade of biological research training in Asia, Europe and America, he joined the Department of Biomedical Sciences, as a tenure track assistant professor in the fall of 2018, focusing on function of sequence variants in development of complex human diseases using state-of-the-art genomics tools.

Research Interests

Due to high mutation burden in regulatory elements, affected cells develop aberrant gene transcription compared with surrounding normal cells that could device them with growth advantage. Some transcripts (including non-coding RNAs) have been used as clinical diagnostic markers for some cancer types whereas the molecular mechanism of their relevance to the cancer development remains largely elusive. Our research goal is to unveil molecular mechanism of how transcriptional aberration affects cancer development, using high throughput, state-of-the-art tools. My current interest focuses on developing genomic tools to:

  1. Dissect of lncRNA function and mechanism in cancer development
  2. Identify of genetic variations that contribute to disease pathogenesis
  3. Study protein-chromatin binding with extremely low number of cells and apply it to study cell heterogeneity

Available Positions

We are seeking highly motivated talented researchers to join the lab as Research Assistants, Graduate Students and Postdoc Fellows all year round. Candidates with training background in either genomics, molecular biology, bioinformatics or mouse model are highly encouraged to apply. Should you be interested, please directly e-mail Dr Yan with your CV and contacts of three references.

Selected Publications

  • Greenwald WW*, Chiou J*, Yan J*, Qiu Y*, Dai N*, Wang A, Nariai N, Aylward A, Han JY, Kadakia N, Regue L, Okino ML, Drees F, Kramer D, Vinckier N, Minichiello L, Gorkin D, Avruch J, Frazer K, Sander MA, Ren B, Gaulton KJ. Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk. Nature Communications. 2019 May 7; 10:2078
  • Yan J, Chen SA, Local A, Liu T, Qiu Y, Dorighi KM, Preissl S, Rivera CM, Wang C, Ye Z, Ge K, Hu M, Wysocka J, Ren B. Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers. Cell Research. 2018 Feb;28(2):204-220.
  • Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science. 2017 May 5; 356(6337).
  • Yan J, Enge M, Whitington T, Dave K, Liu J, Sur I, Schmierer B, Jolma A, Kivioja T, Taipale M, Taipale J. Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites. Cell. 2013 Aug 15; 154(4): 801-13.
  • Jolma A*, Yan J*, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, et al. DNA-binding specificities of human transcription factors. Cell. 2013 Jan 17; 152(1-2): 327-39.