|Office:||1B-109, 1/F, Block 1,
To Yuen Building
Dr Yan received his BSc (in biological sciences) at Tsinghua University and MSc (in biotechnology) at University of Helsinki. He continued his PhD study in Prof. Jussi Taipale’s lab at Karolinska Institutet, investigating molecular mechanism of transcriptional regulation in colorectal cancer cells. After obtaining PhD degree, Dr Yan moved to San Diego in 2015 to study 3D genome organization and gene regulation as a postdoc fellow with Prof. Bing Ren at Ludwig Institute for Cancer Research.
After more than a decade of biological research training in Asia, Europe and America, he joined the Department of Biomedical Sciences, City University of Hong Kong as a tenure-track assistant professor in fall of 2018, focusing on (epi)genome function in development of complex human diseases using state-of-the-art genomics tools.
The 3 billion base-pair human genome was firstly sequenced fifteen years ago, of which only 1% was discovered to code for protein. After putting over a decade of tremendous efforts, we still know very little about the function of the entire genomic sequence. Genetic and epigenetic evidences have suggested that a large portion of human genome plays a regulatory role in gene transcription and is related to health problems including cancer.
Cancer in general has been identified as uncontrolled cell growth and a large amount of mutations have been detected in cancer genome. Due to high mutation burden in regulatory elements, cancer cells largely develop aberrant gene transcription compared with surrounding normal cells that device them with growth advantage. Some transcripts (including non-coding RNAs) have been used as clinical diagnostic markers for some cancer types whereas the molecular mechanism of their relevance to the cancer development remains largely elusive. Our research goal is to unveil molecular mechanism of how transcriptional aberration affects cancer development, using high throughput, state-of-the-art tools. We hope that such knowledge could be translated to improving disease diagnosis and therapeutic strategy.
As new tool is critical for making breakthrough in research, my current interest is focused on developing genomic tools to:
We are seeking highly motivated talented researchers to join the lab as Research Assistants, Graduate Students and Postdoc Fellows all year round. Candidates with training background in either genomics, molecular biology, bioinformatics or mouse model are highly encouraged to apply. Should you be interested, please directly e-mail Dr Yan with your CV and contacts of three references.