Art Machines 2: International Symposium on Machine Learning and Art 2021 will take place from 10th-13th June 2021 at the School of Creative Media, City University of Hong Kong. Art Machines 2 will bring together Academics, Artists and Professionals in the field of Computational Media Art in a four-day symposium on the topic of Machine Learning and Art. This agenda-setting symposium will provide an opportunity for in depth assessment of the impact of Machine Learning on Artistic Media, as well as to reflect on the conditions of existence, range, futures and social significance of computationally based art and media more generally. In addition to the academic keynotes, panels and discussion forums, the symposium will include a curated exhibition of artworks and a student salon.