Dr. Ákos Kenéz is Assistant Professor of Veterinary Physiology at the Department of Infectious Diseases and Public Health. In this position, he coordinates and co-teaches the multidisciplinary Function and Dysfunction course of the Bachelor of Veterinary Medicine programme, which is based on the curriculum of the College of Veterinary Medicine at Cornell University and integrates physiology, pathophysiology, clinical pathology and pharmacology. Further, he works on basic research projects focussing on metabolic health in livestock animals, particularly using metabolomics as a way to explore currently unknown mechanisms of metabolic regulation.
Ákos graduated with a DVM (Doctor of Veterinary Medicine) degree from the University of Veterinary Medicine Budapest, Hungary, and received his PhD degree from the University of Veterinary Medicine Hannover, Germany, after completing his research on metabolic responses of the adipose tissue in dairy cows. During his postdoctoral years at the University of Hohenheim in Stuttgart, Germany, he worked with metabolomics techniques to explain metabolic changes associated with dietary interventions or with pathophysiology in cattle, poultry and horses.
Ákos’ research is focussed on defining molecular mechanisms that drive metabolic integrity or metabolic dysregulation in livestock animals by using metabolomics techniques. The aim of this work is to explore metabolic pathways that ensure high production efficiency and metabolic health at the same time. His current work includes a study to characterise metabolic regulatory mechanisms of a healthy transition from gestation to lactation in dairy cows.
Within this concept, Ákos’ field of interest includes, but is not limited to various aspects of:
- Metabolic fine-tuning mechanisms, including ways of intracellular signalling and cross-talk between organs
- Ways of metabolic dysregulation, such as insulin resistance, mitochondrial dysfunction, oxidative stress, adiposity, inflammation
- Nutrient partitioning, particularly as a function of homeorhetic adaptation
- Further production-associated metabolic challenges in livestock species
- Application of metabolomics for phenotyping and biomarker discovery, bioinformatics and systems biology
(*co-first author, ^corresponding author)
Kinoshita A*, Kenéz Á*, Hasselmann M, Dänicke S, Huber K:
Inter-individual variation in adaptive capacity at onset of lactation: Linking metabolic phenotype with mitochondrial DNA haplotype in Holstein dairy cows.
Scientific Reports (2018) 8:15439. https://doi.org/10.1038/s41598-018-33853-6
Kenéz Á, Koch C, Korst M, Kesser J, Eder K, Sauerwein H, Huber K:
Different milk feeding intensities during the first 4 weeks of rearing dairy calves: Part 3: Plasma metabolomics analysis reveals long-term metabolic imprinting in Holstein heifers.
Journal of Dairy Science (2018) 101:8446-60. https://doi.org/10.3168/jds.2018-14559
Kenéz Á, Warnken T, Feige K, Huber K:
Lower plasma trans-4-hydroxyproline and methionine sulfoxide levels are associated with insulin dysregulation in horses.
BMC Veterinary Research (2018) 14:146. https://doi.org/10.1186/s12917-018-1479-z
Kenéz Á, Dänicke S, Rolle-Kampczyk U, von Bergen M, Huber K:
A metabolomics approach to characterize phenotypes of metabolic transition from late pregnancy to early lactation in dairy cows.
Metabolomics (2016) 12:165. https://doi.org/10.1007/s11306-016-1112-8
McNamara JP, Huber K, Kenéz Á:
A dynamic, mechanistic model of metabolism in adipose tissue of lactating dairy cattle.
Journal of Dairy Science (2016) 99:5649-61. https://doi.org/10.3168/jds.2015-9585
Kenéz Á, Tienken R, Locher L, Meyer U, Rizk U, Rehage J, Dänicke S, Huber K:
Changes in lipid metabolism and β-adrenergic response of adipose tissues of periparturient dairy cows affected by an energy-dense diet and nicotinic acid supplementation.
Journal of Animal Science (2015) 93:4012-22. https://doi.org/10.2527/jas.2014-8833
Kenéz Á, Kulcsár A, Kluge F, Benbelkacem I, Hansen K, Locher L, Meyer U, Rehage J, Dänicke S, Huber K:
Changes of Adipose Tissue Morphology and Composition during Late Pregnancy and Early Lactation in Dairy Cows.
PLoS ONE (2015) 10:e0127208. https://doi.org/10.1371/journal.pone.0127208
Kenéz Á, Locher L, Rehage J, Dänicke S, Huber K:
Agonists of the G protein-coupled receptor 109A-mediated pathway promote antilipolysis by reducing serine residue 563 phosphorylation of hormone-sensitive lipase in bovine adipose tissue explants.
Journal of Dairy Science (2014) 97:3626-34. https://doi.org/10.3168/jds.2013-7662