Opportunity

Developed a microfluidic biosensing system for effective cancer diagnostic and screening.
This is an advanced portable microfluidic apparatus that captures target exosomes and allows detection by plasmonic biosensor for fast, high-sensitivity, high accuracy, and low-cost cancer screening.

Technology

• A portable microfluidic biosensing system for detection of cancer at low concentration
• Biosensor capable of trapping small size cancer markers and sensing small changes
• Nanometer-size cancer markers could be detected by the biosensor
• Electrical force could be applied to increase trapping efficiency of cancer markers in order to increases detection sensitivity
• Fabrication technology, materials, and system design needed for the biosensing system
• Very sensitive, low noise optical detection based on resonant peak shift 

Advantages

• Low manufacturing and operating cost compared to existing apparatus with similar function
• More convenient to use since it is portable, small size, and simpler setup
• Fast detection time
• Low sample volume from tens of ml to µl
• High sensitivity and accuracy to detect low concentration for early stage cancer detection

Applications

• Early stage in trapping and detection of various biomolecules for early disease diagnostic, such as cancer disease 
• Portable system for daily, point-of-care applications with low-cost setup
• Extendable to other disease screening as exosomes