The Research Center for Decentralized Trust Computing (CDTC) was founded at the City University of Hong Kong in December 2018. This center meets the distributed system community's urgent need for world-class expertise in computer science that spans cryptography, blockchain technologies and cryptocurrencies, distributed systems, and system security techniques. Aiming for the foundational support and enabling technologies of blockchain and smart contract, CDTC will focus on the areas of Decentralized Trust Computing, from blockchain foundations and theoretical guarantees, to general secure computations and storage applications atop blockchain, and to safeguarding smart contract from systematization perspectives.

The Research Centre for Multimedia Software Engineering (MERC) aims at contributing to development of technologies of multimedia and emerging media-types, in Hong Kong, Pearl River Delta region and other areas of mainland China as a whole, enabled by research with high societal impact, educated human resources, and commercialization of new software from top-class engineering researches.

The Research Centre for Advanced Structural Materials (CASM) is to advance the fundamentals and technologies in advanced structural materials which will create innovative solutions for different key industrial sectors, such as biomedical, automotive, aerospace, sustainable energy.

The Research Centre for Biosystems, Neuroscience, and Nanotechnology (CBNN) merges nanotechnology with biosystems and neuroscience to create a revolutionary impact on many aspects of medicine. The centre aims at developing materials, structures, devices, and microsystems with nanometre precision for single molecule and cell interactions.

Research Centre for Complexity and Complex Networks (CCCN) aims to promote fundamental and applied research on the emerging and cutting-edge technology of chaos control and synchronization, as well as complex dynamical networks, targeting academic leadership and commercial and industrial applications.

The Research Centre for Functional Photonics (CFP) focuses on fundamental studies of light-matter interactions, as well as on design and applications of functional optical materials, with an interdisciplinary team of scientists from departments of Physics, Chemistry, Mechanical Engineering, Biomedical Engineering, and Materials Science and Engineering at CityUHK.

The Research Centre for Robotics and Automation (CRA) is established by a multidisciplinary research team aiming to develop new knowledge and technology to integrating cyber-infrastructure with engineering systems to enable new technological developments in areas such as manufacturing automation, nanotechnology and drug discovery.

The Research Centre for Smart Energy Conversion and Utilization (CSCR) focuses on the fundamental and applied research in power electronics and its applications.

The Research Centre of Super-Diamond and Advanced Films (COSDAF) aims to be internationally recognized as a leading research centre in nanomaterials and nanotechnology.

The mission of Centre for Animal Health and Welfare is to improve the quality of life of animals by producing high impact research that will bring evidence-based solutions to major health and welfare problems.

The mission of Research Centre for Applied One Health Research and Policy Advice (OHRP) is to develop policies at local, national, regional and international levels for the prevention and control of infectious animal diseases affecting human health, as well as animal health.

The Ability R&D Energy Research Centre (AERC) focuses on research to develop the state-of-the-art energy-efficient and energy-saving technologies to reduce fossil fuel consumption, and to develop clean and renewable energy technologies to achieve sustainable energy supply.

The objectives of the Research Centre for Global Supply Chain (CGSC) are to promote economic prosperity of the countries along the belt and road and regional economic cooperation, to strengthen exchanges and mutual learning between different civilizations, and to promote world peace and development.

The Research Centre for Applied Computing and Interactive Media (ACIM) is to promote the development of core competencies in the areas of computational science and engineering, data visualization, digital humanities, new media technology and the creative arts.

The Research Centre for Chinese and Comparative Law (CCCL) aspires to become the premier Chinese and comparative law research centre in the Asia Pacific region through organizing and facilitating research on Chinese and comparative law.

The Research Centre for Hong Kong Commercial and Maritime Law (HKCML) seeks to enhance and promote research in commercial law and maritime law, and to provide educational opportunities to scholars, lawyers and business professionals.

Named after the world-renowned linguist Professor M.A.K. Halliday, the Halliday Centre for Intelligent Applications of Language Studies (HCLS) aims to advance the knowledge about how language works to construe human experience and enact social relationships, and to apply linguistic insights in education and other applications.

The Research Centre for Communication (CCR) aims to investigate the cutting-edge issues under the forces of technological convergence and media globalization in the Asian context. Its core members are at the forefront of research and publications in international communication, media effects, new media, communication for social change, and political economy of the media.

The Research Centre for East Asian and Comparative Philosophy (CEACOP) aims to promote and enhance the study of East Asian and comparative philosophy, by conducting research programmes in East Asian and comparative ethics, political philosophy, law, religion, the ethical status of non-human animals, and environmental ethics.

The Research Centre for Sustainable Hong Kong (CSHK), established in June 2017, is an Applied Strategic Development Centre of CityUHK. CSHK houses the SusHK Hub and supports all the research and collaborative activities with stakeholders from different sectors and regions. The mission of CSHK is to analyze and develop solutions to meet critical sustainability issues in Hong Kong from a multi-disciplinary perspective. Professor Linda Chelan Li, Department of Public Policy of CityUHK, is appointed as Centre Director.

The Tung Biomedical Sciences Centre serves as an interdisciplinary research hub dedicated to biomedical research and development, and provide a platform for multidisciplinary teams of investigators and students to work together and understand the fundamental mechanisms of initiation and progression of diseases, and to translate new discoveries into novel diagnostic and therapeutic strategies for prediction, prevention and treatments of these diseases.

Jointly established by the College of Liberal Arts and Social Sciences (CLASS) and the School of Law (SLW), the CLASS/SLW Research Centre for Public Affairs and Law (CPAL) promotes world class research on interdisciplinary studies in social sciences and law disciplines related to public affairs. It builds knowledge using evidence-based approaches, big data and devising policy and law-based solutions to policy challenges.

The Liu Bie Ju Centre for Mathematical Sciences (LBJ) is to conduct first-class research in applied mathematics and in computational mathematics. As a leading research centre in the Asia-Pacific region, its basic objective is to strive for excellence in applied mathematical sciences.

Research Engagement Centre for Judicial Education and Research cum Identification of Hong Kong Law (JERI) oversees the management and strategic development of the Chinese judges programmes, currently run by the School of Law (SLW).