Department of Biomedical Engineering
City University of Hong Kong
Department of Biomedical Engineering
Prof. SHI, Peng

Prof. SHI, Peng

BS(WHU), MS(UIC), M.Phil. (Columbia), Ph.D. (Columbia)

Professor

Research Interest

  • Neural Engineering
  • High-throughput Screening
  • Single Cell Based Analysis
  • Biological Application of Micro/Nano Systems

    • Phone: +852 3442-9529
    Email: pengshi@cityu.edu.hk
    Address: YEUNG-P6423
    Web: Group Homepage

    Jan 2010 – Nov 2011 Postdoctoral
    Research Fellow    		 Massachusetts Institute of Technology (MIT)
    Department of Electrical Engineering and Computer Science
    Department of Biological Engineering    		 Boston, MA
    2009 Ph.D. Columbia University
    Department of Biomedical Engineering    		 New York, NY
    2006 M.Phil. Columbia University
    Department of Biomedical Engineering    		 New York, NY
    2002 B.S. Wuhan University
    Department of Electrical Engineering    		 Wuhan, China

    July 2016 - Present Associate Professor (with tenure) City University of Hong Kong
    Department of Mechanical and Biomedical Engineering
    Nov 2011 – June 2016 Assistant Professor City University of Hong Kong
    Department of Mechanical and Biomedical Engineering
    Jan 2010 – Nov 2011 Postdoctoral Research Fellow Massachusetts Institute of Technology (MIT)
    Department of Electrical Engineering and Computer Science
    Department of Biological Engineering
    Sept 2004 – Dec 2009 Graduate Research Assistant Columbia Univeristy
    Department of Biomedical Engineering
    Sept 2006 – May 2007 Graduate Teaching Assistant Columbia Univeristy
    Department of Biomedical Engineering

    • Speical Recognitions of Young Scholars, World Cultural Council (2018)
    • President Award for Research Excellence, City University of Hong Kong (2017)
    • Simons Foundation Postdoctoral Fellowship (2010-2011, One of the 11 recipients of this year)
    • Outstanding Abstract Award, Biomedical Engineering Society Annual Meeting (2009)
    • Chinese Oversea Student and Scholar Entrepreneurship Competition, Finalist (2008)
    • Graduate Student Fellowship, Columbia Univeristy (2004 – 2009)
    • Ren-Ming Excellence Award, Wuhan Unviersity (2001)

    1. “Injectable Nanoreinforced Shape-Memory Hydrogel System for Regenerating Spinal Cord Tissue from Traumatic Injury”. Chong Wang†, Haibing Yue†, Qian Feng, Bingzhe Xu, Liming Bian, and Peng Shi*. ACS Appl. Mater. Interfaces., 2018, DOI: 10.1021/acsami.8b08929.
    2. “Energy transfer-based biodetection using optical nanomaterials”. Bing Chen, Qianqian Su*, Wei Kong, Yuan Wang, Peng Shi, Feng Wang*. J. Mater. Chem. B, 2018, 6, 2924-2944.
    3. “A cancer cell-selective and low-toxic bifunctional heterodinuclear Pt(IV)-Ru(II) anticancer prodrug”. Lili Ma, Xudong Lin, Cai Li, Zoufeng Xu, Chun-Yin Chan, Man-Kit Tse, Peng Shi, and Guangyu Zhu*. Inorg. Chem. 2018, 57 (5), pp 2917–2924.
    4. “Core–Shell–Shell Upconversion Nanoparticles with Enhanced Emission for Wireless Optogenetic Inhibition”. Lin Xudong, Chen Xian, Zhang Wenchong, Liao Qinghai, Fang Peilin, Chen Xi, He Jufang, Liu Ming, Wang Feng*, Shi Peng*. Nano Letters, 18, 2, 948-956, 2018.
    5. “Regeneration of Cortical Tissue from Brain Injury by Implantation of Defined Molecular Gradient of Semaphorin 3A”. Zhen Xu, Wei Wang, Yutian Ren, Wenchong Zhang, Peilin Fang, Linfeng, Huang, Xin Wang, Peng Shi*. Biomaterials, 157:125-135, 2018.
    6. “Tetherless Near-infrared Control of Brain Activity in Behaving Animals Using Fully Implantable Upconversion Microdevices”. Ying Wang, Xudong Lin, Xi Chen, Xian Chen, Zhen Xu, Wenchong Zhang, Qinghai Liao, Xin Duan, Xin Wang, Ming Liu, Feng Wang, Jufang He, Peng Shi*. Biomaterials, 142, 136-148, 2017.
    7. “Multiplexed Optogenetic Stimulation of Neurons with Spectrum-Selective Upconversion Nanoparticles”. Xudong Lin, Ying Wang, Xian Chen, Runhuai Yang, Zixun Wang, Jingyu Feng, Haitao Wang, King W. C. Lai, Jufang He, Feng Wang*, Peng Shi*. Advanced Healthcare Materials, 2017, 6, 1700446. [frontispiece highlight]
    8. “Cell Generator: A Self-sustaining Bio-hybrid System Based on Energy Harvesting from Engineered Cardiac Micro-tissues”. Xu Bingzhe, Lin Xudong, Li Wei, Wang Zixun, Zhang Wenchong, Shi Peng*. Advanced Functional Materials, 2017, 2017, 27, 1606169.
    9. “Anti-counterfeiting Patterns Encrypted with Multi-Mode Luminescent Nanotaggants”. Tianying Sun, Bingzhe Xu, Bing Chen, Xian Chen, Mingyu Li*, Peng Shi*, and Feng Wang*. Nanoscale, 2017, 23;9(8):2701-2705.
    10. “Investigation of the subcellular neurotoxicity of amyloid-β using a device integrating microfluidic perfusion and chemotactic guidance”. Wei Li, Zhen Xu, Bingzhe Xu, Chung Yuen Chan, Xudong Lin, Ying Wang, Ganchao Chen, Zhigang Wang, Qiuju Yuan, Guangyu Zhu, Hongyan Sun, Wutian Wu, Peng Shi*. Advanced Healthcare Materials, 2016.
    11. “Mechanically Resilient, Injectable, and Bioadhesive Supramolecular Gelatin Hydrogels Crosslinked by Weak Host-Guest Interactions Assist Cell Infiltration and In Situ Tissue Regeneration”. Q Feng, K Wei, S Lin, Z Xu, Y Sun, Peng Shi, G Li, L Bian. Biomaterials, 101:217-218, 2016.
    12. “Controllable 3D alginate hydrogel patterning via visible-light induced electrodeposition”. G Dai, W Wan, Y Zhao, Z Wang, W Li, Peng Shi, Y Shen. Biofabrication 8 (2), 025004.
    13. “Autonomous system for cross-organ investigation of ethanol-induced acute response in behaving larval zebrafish”. Xudong Lin, Vincent Li, Siya Chen, Chung-Yuen Chan, Shuk-Han Cheng* and Peng Shi*. Biomicrofluidics, 10, 024123, 2016. [Featured on Biomicrofluidics facebook].
    14. “Ultrathin MXene-micropattern-based Field-effect Transistor for Probing Neural Activity”. Bingzhe Xu, Minshen Zhu, Wencong Zhang, Xu Zhen, Zengxia Pei, Qi Xue, Chunyi Zhi*, Peng Shi*. Advanced Materials, 28(17): 3333-3339, 2016. [Featured as back cover of this issue, covered by MaterialsViewsChina].
    15. “Controlled nanoparticle release from stable magnetic microbubble oscillations”. Yu Gao, Chon U Chan, Qiushi Gu, Xudong Lin, Wencong Zhang, David Yeo, Astrid Alsema, Manish Arora, Mark Seow Khoon Chong, Peng Shi, Claus-Dieter Ohl, and Chenjie Xu. NPG Asia Materials, 2016.
    16. “Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo”, Jinfeng Zhang, et al, Peng Shi, Lung-Chen Tu, Chia-Ching Chang, Xiaohong Zhang, Xianfeng Chen, Wenjun Zhang, Chun-Sing Lee. ACS Nano, 9(10), 9741-9756, 2015.
    17. “Interrogation of Cellular Innate Immunity by Diamond-nanoneedle-assisted Intracellular Molecular Fishing”. Zixun Wang, Yang Yang, Zhen Xu, Ying Wang, WenJun Zhang*, Peng Shi*. Nano Letters, 15(10):7058-63, 2015.
    18. Wei Li, Rongcong Luo, Xudong Lin, Amol D. Jadhav, Zicong Zhang, Li Yan, Chung-Yuan Chan, Xianfeng Chen, Jufang He, Chia-Hung Chen*, Peng Shi*. Remote Modulation of Neural Activities via Near-infrared Triggered Release of Biomolecules”. Biomaterials, 65, pp. 76-85, 2015.
    19. Amol D. Jadhav, Bao Yan, Rong-Cong Luo, Li Wei, Xu Zhen, Chia-Hung Chen, Peng Shi*. “Photoresponsive Microvalve for Remote Actuation and Flow Control in Microfluidic Devices”. Biomicrofluidics, 9, 034114, 2015.
    20. A.D. Jadhav, W. Li, Z. Xu, and P. Shi*. “Compartmentalized Platforms for Neuro-pharmacological Research”. Current Neuropharmacology, 13, 1-14, 2015.
    21. Qiang Ju, Xian Chen, Fujin Ai, Dengfeng Peng, Xudong Lin, Wei Kong, Peng Shi, Guangyu Zhu and Feng Wang. “An upconversion nanoprobe operating in the first biological window”. J. Mater. Chem. B, 2015, 3, 3548-3555.
    22. W. Li, Q. Tang, A.D. Jadhav, A. Narang, W. Qian, P. Shi*, and S.W. Pang.“Large-scale Topographical Screen for Investigation of Physical Neural-Guidance Cues”. Scientific Reports 2015 5:8644.
    23. X. Lin, S. Wang, X. Yu, Z. Liu, F. Wang, W. T. Li, S. H. Cheng, Q. Dai, P. Shi*. “High-throughput Mapping of Brain-wide Activities in Awake and Drug-responsive Vertebrates”. Lab on a Chip 2015 15(3):680-9.
    24. T.Y. Chang, P. Shi*, J.D. Steinmeyer, I. Chatnuntawech, P. Tillberg, K.T. Love, P.M. Eimon, D.G. Anderson, M.F. Yanik*. “Organ-targeted high-throughput in vivo biologics screen identifies vehicles for RNA delivery”. Integrative Biology, 2014, 6, 897-898. (Front Cover)
    25. Y. Wang, Y. Yang, L. Yan, S. Y. Kwok, W. Li, Z. Wang, X. Zhu, G. Zhu, W. Zhang*, X. Chen* and P. Shi*. “Poking Cells for Efficient Vector-free Intracellular Delivery” Nature Communications, 5: 4466, 2014.
    26. R. Luo, Y. Cao, P. Shi, C.H. Chen. “Near-infrared Light Responsive Multi-compartmental Hydrogel Particles Synthesized through Droplets Assembly Induced by Superhydrophobic Surface” Small, 2014, Jul 24. doi: 10.1002/smll.201401312. (Front Cover)
    27. R.C. Luo, Z.H. Lim, W. Li, P. Shi, C.H. Chen. “Near-infrared light triggerable deformation-free polysaccharide double network hydrogels” Chemical Communications, 2014 May 22.
    28. W Li†, Z. Xu†, X. Lin, R. Luo, C. Chen, P. Shi*. "NeuroArray: A Universal Interface for Patterning and Interrogating Neural Circuitry with Single Cell Resolution" Scientific Reports, 2014 4:4784.
    29. Tang QY, Tong WY, Shi J, Shi P, Lam YW, Pang SW. “Influence of engineered surface on cell directionality and motility”. Biofabrication, 6(1):015011 2014.
    30. Y. Wang, Z. Xu, L.C. Kam, P. Shi*. “Site-Specific Differentiation of Neural Stem Cell Regulated by Micropatterned Multicomponent Interfaces” Advanced Healthcare Materials, 3(2):214-20, 2014. (Back cover)
    31. S. Nedelec, M Peljto, P. Shi, M.W. Amoroso, L.C. Kam, H. Wichterle. “Differential requirement for local protein synthesis in motor neuron subtype specific response to axon guidance cues”. Journal of Neuroscience, 32(4):1496-506 2012.
    32. P. Shi, M.A. Scott, B. Ghosh, D. Wan, Z.Wissner-Gross, R. Mazitschek, S. Haggarty, M.F. Yanik. “Synapse Microarray Identification Small-molecules That Enhance Synaptogenesis”. Nature Communications. Oct 25, 2:510, 2011. (This paper was highlighted as MIT homepage on Oct 26, 2011, has been reported by MIT news, R&D Magzine, MassHighTech, Medical Express, NextBigFuture, Boston blog, etc.).

    • “Compartmentalized Synapse Microarray for High-Throughput Screening” in Microfluidic and Compartmentalized Platforms for Neurobiological Research, Biffi Emilia (Ed.), Humana Press, 2015. (Invited)

    1. China Patent, No. 201410337234.5; Method and Apparatus for Delivery of Materials to Cells.
    2. US Patent, US9394547B2; Method and Apparatus for Delivery of Molecules to Cells.
    3. US Patent Application, No. 14705128; Systems and Methods for Automated Handling of Live Organisms.
    4. US Application, US20160051353; High-throughput Organ-targeted Microinjection System.
    5. US Patent Application, No. 15875385; Method of Determining Target Nucleic Acid.
    6. US Patent Application, No. 15695372; Wireless Optogenetic Device and Associated Radiation System

    Last modified on 1 July, 2020