Dr. CHEN, Chia-Hung

Dr. CHEN, Chia-Hung

B.S. (NTU), M.S. (Harvard), Ph.D. (Cambridge)

Associate Professor

Research Interest

  • Microfluidic Droplets
  • Single Cell Analysis
  • Smart Hydrogels
  • Platform Engineering for Quantitative Biology
  • Phone: +852 3442-9547
    Email: chiachen@cityu.edu.hk
    Address: YEUNG-P7726
    Web: https://imb-cch.net/

    Dr. Chen is focused on developing integrative platforms for biomedical applications. Compared with most platforms using gene sequence for quantitative biology, integrative functional assay offers unique advantages for the rapid characterization of biological samples for diagnosis and timely precision medicine. With the possibility of high-throughput biological sample screening and cell sorting using the integrative platform, statistically information could be obtained for effective quantitative biological analysis. For example, an intelligent system that integrated imaging technology, multiplexed chemical sensors and a computational data-analysis method was previously developed to analyze small amounts of physiological samples to determine the disease progression of individual patients with cancer. Before joining City University of Hong Kong, Dr. Chen worked at National University of Singapore and Massachusetts Institute of Technology. He received his Ph.D. degree at University of Cambridge. He earned his M.S. degree at Harvard University, and earned his B.S. degree at National Taiwan University.

    2010 Ph.D. Physics University of Cambridge
    2006 M.S. Applied Physics Harvard University
    2004 B.S. Physics National Taiwan University

    • Lab on a Chip Emerging Investigator, 2018
    • MicroTAS Presentation Award, 2010
    • Cambridge Overseas Trust 2006-2009
    • Overseas Research Studentship (Cambridge) 2006-2009
    • Harvard Alumni Scholarship 2005

    • Plasmonic Droplet-Screen for Single-Cell Secretion Analysis, S. C. Wei, M. N. Hsu, and C. H. Chen, Biosensors and Bioelectronics, 144, 111639, 2019
    • Upconversion Amplification through Dielectric Superlensing Modulation, L. Liang, D. Teh, N. C. Dinh et al C. H. Chen, A. All, N. V. Thakor and X. Liu, Nature Communications, 10, 1391, 2019
    • Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions, H. Tan, S. Guo, N. Dinh, R. Luo, J. Lin and C. H. Chen, Nature Communications, 8, 663, 2017
    • Single Cell Multiplexed Assay for Proteolytic Activity Using Droplet Microfluidics, E. X. Ng, M. A. Miller, T. Jing, and C. H. Chen, Biosensors and Bioelectronics, 81, 408-414, 2016
    • Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array. E. X. Ng, M. A. Miller, T. Jing, D. A. Lauffenburger and C. H. Chen, Lab on a Chip, 15, 1153-1159, 2015
    • Gradient Porous Elastic Hydrogels with Shape-memory Property and Anisotropic Responses for Programmable Locomotion. R. Luo, J. Wu, N. Dinh, and C. H. Chen, Advanced Functional Materials, 25, 7272-7279, 2015.
    • ADAM-10 regulates cell migration via Jnk/p38 and opposing feedback through dual ligand and receptor shedding in invasive disease. M. A. Miller, A. S. Meyer, M. T. Beste, Z. Lasisi, S. Reddy, K. W. Jeng, C. H. Chen, J. Han, K. Isaacson, L. G. Griffith, and D. A. Lauffenburger, PNAS, 2013, 110, E2074–E2083
    • Multiplexed Protease Activity Assay for Low-Volume Clinical Samples Using Droplet-Based Microfluidics and Its Application to Endometriosis. C. H. Chen, M. A. Miller, A. Sarkar, M. T. Beste, K. B. Isaacson, D. A. Lauffenburger, L. G. Griffith, and J. Han. JACS, 2013, 135, 1645-1648
    • Enhancing protease activity assay in droplet-based microfluidics Using a Biomolecule Concentrator. C. H. Chen, A. Sarkar, Y. Song, M. A. Miller, S. J. Kim, L. G. Griffith, D. A. Lauffenburer and J. Han, JACS, 2011, 133, 10368-10371
    • Microfluidic assembly of magnetic hydrogel particles with uniformly anisotropic structure. C. H. Chen, A. R. Abate, D. Lee, E. M. Terentjev and D. A. Weitz, Advanced Materials, 2009, 21, 3201-3204

    Last modified on 6 July, 2022