External Grants

2022

Development and Pre-clinical Study of Externally Activated Nanomedicine for Anti-Cancer Therapy

ITF
2022

Development of Damage-healable Structural- Color Material for Waterborne Wood Paints

ITF
2022

Development of a Novel Therapeutic to Promote Anticancer Immunity by Manipulating Endosomal Trafficking of PD-L1

ITF
2022

Development of Bisbenzylisoquinoline Alkaloid- Berbamine and Its Analogs to Prevent and Treat COVID-19 by Compromising the Endosome- lysosome Transport of ACE2

ITF
2022

丁香假單胞菌毒力負調控因數的信號通路研究

NSFC
2022

組蛋白H2BE113K突變影響核小體酸性口袋功能驅動乳腺癌發生發展的機制研究

NSFC
2022

開發PI3K抑制劑以控制新型冠狀病毒肺炎中的細胞因數風暴

NSFC
2022

基於微納技術的腫瘤精準診療技術研發與應用項目

Project funded by the Mainland Government
2022

lncRNA DANCR調控間充質幹細胞衰老的機制研究

Project funded by the Mainland Government
2022

FAM129B信號通路在內體運輸和腫瘤轉移中的功能和機制研究

Project funded by the Mainland Government
2022

肝癌腫瘤微環境的免疫逃逸機制的研究

Project funded by the Mainland Government
2022

磁控超滑表面用於微液滴的定向快速收集和病原檢測

Project funded by the Mainland Government
2022

多酚抑制丁香假單胞菌毒力的分子機理和應用研究

Project funded by the Mainland Government
2022

Exploring a phosphate signal transduction pathway in Pseudomonas syringae virulence

GRF
2022

Inflammasome mediates YAP-induced chronic inflammation in endothelium during the initiation of atherosclerosis

GRF
2022

Unraveling the Functional Roles of yafB in Metabolic Adaptation of Bacteria during Infection

GRF
2022

Combating Hypoxic Tumors with Self-Assembled Nanophotosensitizers based on Biotinylated Nitric Oxide-Releasing Phthalocyanines

GRF
2022

Investigating the roles of the Srebp2-Bmp2 pathway in mouse eye size control and myopia development

GRF
2022

Unravelling the molecular mechanism of DNA demethylation around CTCF binding sites in mammalian cells

GRF
2022

Delineating the mechanisms of DANCR-Rac1 in triple-negative breast cancer invasion and metastasis

GRF
2022

Research on the Mechanism of Improving the Function of Vascular Endothelial in Diabetic Rats

Contract Research
2022

Gut Microbiome Remodeling Accelerates Ageing-induced Cardiometabolic Disorders

PDFS
2022

Genome-wide characterization of virulence-associated transcription factors in Pseudomonas aeruginosa

HMRF
2022

Dissecting the Functional Role of Prevalent Incompatible Group I1 Plasmid isolated from Human and Animals in Hong Kong

HMRF
2022

NIP7 as a novel therapeutic target for triple-negative breast cancer

HMRF
2022

內體運輸抑制劑爲新型抗腫瘤轉移藥物的功能和機制研究

Project funded by the Mainland Government
2021

Gut Microbiota Remodelling Contributes to the Aging-Induced Endothelial Dysfunction and Vascular Oxidative Stress

HMRF
2021

COVID-19 Detection based on Fluorescence Polarization Measurement

ITF
2021

Comparing Dengue Mosquito Predictivity of Gravitrap to Ovitrap Surveillance Systems Using Weather Data in Hong Kong

HMRF
2021

A CRISPR Screen for Diverse Codes of Cellular Reprogramming in Mouse Retinas (2nd Phase)

Contract Research
2021

Systemic Benefits of Physical Activity: Crosstalk between Organs on Signal Transduction from Mechano-stimulation to Metabolism

SRFS
2021

TGF-β2 Inhibition Ameliorates Pulmonary Arterial Hypertension through Suppressing Endothelial-mesenchymal Transition

GRF
2021

Effectiveness of the At-home SARS-CoV-2 Detection Test in HK

Contract Research
2021

Synthesis of Cell Penetrating Peptide-conjugated Sunitinib

Contract Research
2021

Investigate the function of AATF in X chromosomal inactivation and transcriptional gene regulation

GRF
2021

Dissecting signaling pathway and molecular mechanism of key phosphorelay crosstalk in Pseudomonas syringae virulence

GRF
2021

Overcoming the intratumor heterogeneity by multi-scale spatial characterizations of tumor microenvironment for integrative colorectal cancer classification

GRF
2021

Noncovalent Interaction Assisted Assembly and Manipulation of Liquid Metals in Supramolecular Polymers

GRF
2021

大宗食品中高污染致病性蠟樣芽孢杆菌危害形成與防控分子機制

Project funded by the Mainland Government
2020

Modelling of Hong Kong COVID-19 Control Strategies Considering Different Population Immunity Scenarios

HMRF
2020

Precision Prediction Models for COVID-19

ITF
2020

Rapid Detection of SARS -CoV-2 Virus Using Isothermal Nucleic Acid Lateral Flow Assay (IsoNALFA)

ITF
2020

肿瘤微环境异质性与食管鳞癌复发转移及治疗耐受研究

Project funded by the Mainland Government
2020

合成生物系统在对持久性有毒污染物的感知与识别中的适用性及检测能力

Project funded by the Mainland Government
2020

Dissect the molecular mechanisms of HERV-H mediated shaping of chromatin 3D structure in human pluripotent stem cells

ECS
2020

Revealing signaling pathway of novel two-component system TsiRS in regulating virulence of Pseudomonas syringae

GRF
2020

Structural basis of Hsp27 in the regulation of hnRNP A1 protein relocalization upon enterovirus A71 infection

GRF
2020

Inter-regional communication mechanisms mediated by circadian clocks in pathological conditions of the brain

GRF
2020

Concerted Activation of Photosensitizers and Release of Anticancer Drugs Through Tetrazine-Induced Bioorthogonal Decaging Reactions

GRF
2020

Developing High-strength Supramolecular Adhesives with Controlled Liquid Inclusion: from Mechanistic Study to Antibacterial Applications

GRF
2020

Mechanistic studies of CapZβ signaling in the maturation of early endosomes

GRF
2020

Non-canonical NAD-capped RNAs in Arabidopsis: Mechanisms of Capping and Decapping and Molecular and Physiological Functions

CRF
2019

Harnessing Plasmacytoid Dendritic Cells for Cancer Immunotherapy

CROU_RMG
2019

Gene Therapies Targeting BCL11A for Beta-thalassemia Treatment Development

Donation
2019

Neuroplasticity Induced by the Administration of Cholecystokinin Tetrapeptide and Noise Exposure as a Novel Strategy for the Treatment of Tinnitus

HMRF
2019

Using Extracellular Vesicles to Deliver siRNAs against FLT3 Mutants for Personalized Treatments against Drug-resistant Acute Myeloid Leukemia

HMRF
2019

Temporal Weighting Functions for Spatial Cues and Their Potential Relevance for Better Binaural Hearing with Cochlear Implants

HMRF
2019

Unlock the Regenerative Capacity of Müller Glia in Mammalian Retinas by Wnt/p27kip1 Signaling

HMRF
2019

Investigation of Host Genes Involved in the Functions of Clostridium Difficile Toxins

HMRF
2019

Patient-Derived Preclinical Models for Translational Cancer Research: a Hong Kong-based Biotechnology Centre for Genomic Medicine

RIF
2019

Development of an Integrated Microfluidics System for Multi-level High Content Screening of Anti-tumor Drugs

RIF
2019

Transparent and Healable Anti-smudge Polymer Coatings on Various Substrates

ITF
2019

CCK-B Receptor Antagonists For The Treatment Of Depression Especially Chronic Pain Comorbid Depression Of Elderly

ITF
2018

Croucher Start-up Allowance

CROU
2018

Developing Sodium Acetate As Novel Anti-Pseudomonas Syringae Agent

ITF
2018

A Stem Cell Approach to Dissect the Molecular Basis of Neurodegenerative Diseases

TBRS
2018

The study of glioma-derived exosomes in tumor progression via MCT1 and its ancillary protein, CD147

GRF
2018

Multi-omic molecular subtyping of ovarian high-grade serous carcinoma and multidimensional network inference for dissecting the mesenchymal subtype specific regulatory mechanisms

GRF
2018

The role of the circadian clock as a switch for reactive astrocyte status in neurodegeneration

GRF
2018

Delineating the function and regulation of Vangl2 in epithelial-to-mesenchymal transition (EMT)

GRF
2018

Tinnitus alleviation by activation of dendritic IA channels

GRF
2018

Elucidate the biological significance of Histone H2BG54D mutation in pancreatic cancer

GRF
2018

Cholecystokinin administration rescues thalamocortical neuroplasticity in old rodents

GRF
2018

Study of sRNA-regulated transposition of IS element carrying antibiotic resistant genes

GRF
2018

Neural mechanisms of prediction signalling along the cortical auditory pathway

GRF
2018

Neuroprotection by driving microglia M2 polarization after traumatic brain injury: therapeutic and mechanistic approaches

GRF
2018

Impairment of schemas and memory consolidation and disruption of schemas-linked interactions between hippocampal and anterior cingulate cortex in chronic visceral pain

GRF
2018

Inhibitory gating of neural circuits for dynamic representation of distinct odor features

ECS
2018

Unraveling the RhpRS-mediated signaling pathway of type III secretion system in Pseudomonas syringae

ECS
2018

Investigating the function of Spleen Tyrosine Kinase (Syk) as an important regulator of terminal erythropoiesis

ECS
2018

Development of novel strategies for enriching functionally mature cardiomyocytes derived from human pluripotent stem cells

ECS
2018

Dissecting the Molecular Mechanism of AnvM-mediated Signal Transduction during Pseudomonas Aeruginosa Infection

HMRF
2018

Impaired Communications in Anterior Cingulate Cortex Neural Network in the Rats with Trigeminal Neuropathic Pain Is Associated with Decision-making Deficits

HMRF
2018

Engineering Red Blood Cells for the Delivery of Metabolic Enzymes against Niemann-pick Disease and Other Sphingolipidoses

HMRF
2018

A Gene Therapy Approach to Stimulate Retinal Regeneration by Targeted Expression of Atoh7

HMRF
2018

Therapeutic Potential of Activator Protein 4 in Peripheral Nerve Injury

HMRF
2018

Regulation and Mechanism of Tumor-intrinsic Oncogene Pathways in Mediating an Immune Suppressed Microenvironment in Hepatocellular Carcinoma

CRF
2018

A Study of Self-restraining Mechanisms of DNA Damage Surveillance and Repair

CRF
2018

Bio-inspired Surface Engineering for Phase Change Heat Transfer: From Fundamental Understanding to Practical Applications

CRF
2017

Akt3-specific Signaling Networks for Therapeutic Intervention of Triple-negative Breast Cancer

GRF
2017

GABAergic Cholecystokinin Enhances the Local Inhibitory Effect in the Auditory Cortex

GRF
2017

Development of Advanced Photodynamic Molecular Beacons with Multiple Controls for Targeted Photodynamic Therapy

GRF
2017

Dissecting the Novel Role of Formin-2 in Axonal Regeneration and the Underlying Mechanisms

GRF
2017

Natural Sound Statistics in Auditory Scene Analysis

GRF
2017

Consensus Molecular Subtyping of Pancreatic Ductal Adenocarcinoma and Tumor-intrinsic Regulatory Network Inference from Deconvolved Gene Expression Profiles

GRF
2017

Dissecting the Mechanism and Function of GAPDH in Cyclic ADP-Ribose (cADPR)-mediated Ca2+ Signaling in Mammalian Cells

GRF
2017

Communication mechanisms between transcriptional and translational machineries through the circadian clock

GRF
2017

Role of Oligodendroglial MCT1 in Myelination of the Neonatal Brain

ECS
2017

Mechanisms of Regulating Planar Cell Polarity by Deubiquitinating Enzyme USP7 in Cancer Cells

ECS
2017

TNF-a–Mediated Mechanism and Treatment of Hearing Loss-induced Tinnitus

HMRF
2017

Assay Platforms for CCK-B Receptor Agonists as Potential Treatment for Amnestic Mild Cognitive Impairment

ITF
2017

Therapeutic Potential Of Neural Motor Prostheses Device For The Treatment Of Spinocerebellar Ataxia

ITF
2017

L-lactate Release by Optogenetic Activation of Astrocytes Rescues Decision-making Deficit in Visceral Hypersensitive Rats

NSFC
2017

Cortical Mechanisms of Temporal Predictions in Processing Rhythmic Sounds and Speech

EC/RGC
2016

Cortical cholecystokinin as a chemical switch enabling auditory long-term potentiation in the thalamus

GRF
2016

Vagus nerve stimulation modulates neuronal spike field phase locking and synchrony cross areas associated with facilitation of decision-making in rats

GRF
2016

Development of an integrated microfluidic-based system for single cell mutation analysis and drug sensitivity test of circulating tumor cells/cell clusters

GRF
2016

Study of Slippery Nanocomposite with Controlled Self-healing Ability for Biofouling Prevention

GRF
2016

New insight into HDAC1 as a molecular linker between neurodegeneration and circadian clocks

ECS
2016

The role of tumor-secreted miR-125b in fibroblast differentiation during metastasis

ECS
2016

A functional study of the Glut1/BSG1 complex in photoreceptors: a possible therapeutic target for degeneration?

ECS
2016

The neurobiological mechanisms of schizophrenia via graphene-based wearable electronics

ECS
2016

Development of Smart Theranostic Agents for Imaging and Photoinactivation of beta-Lactamase-Producing Bacteria

HMRF
2016

Unveiling the Disseminative Characteristics and Bacterial Fitness of Major Multidrug Resistance Plasmids by Genomics and RNomics Analysis

HMRF
2016

Local Infusion of Cholecystokinin in the Auditory Cortex and Successive Sound Stimuli Lead to Epileptic Seizures

HMRF
2016

Targeting Oncogenic MicoRNA-125 in Acute Myeloid Leukemia

HMRF
2016

Neural Probes with Flexible and Floating Microelectrode Arrays to Study the Mechanisms of Decision-making by Vagus Nerve Stimulation in Rats

ITF
2016

Detection of Actionable Genetic Alterations in Lung Cancer

ITF
2016

Hong Kong Chinese Materia Medica Standards for Decoction Pieces

Project funded by HKSAR department
2015

Molecular basis for interspecies transmission and pathogenesis of Middle East Respiratory Syndrome Coronavirus

TBRS
2015

Neuronal Mechanism of Cholecystokinin-Facilitated Cross-modal Learning and Memory

CRF
2015

TARGETING VAGAL AFFERENT IN LEARNING AND MEMORY IMPAIRMENTS ASSOCIATED WITH CHRONIC VISCERAL PAIN: THE ROLE OF CHOLECYSTOKININ

GRF
2015

How Activation of the Auditory Thalamus Induces Neuronal Plasticity in the Auditory Cortex?

GRF
2015

The Molecular Mechanism of PIM1 Response to Facilitate Human Enterovirus 71 Infection

GRF
2015

Targeting Vegal Afferent in Learning and Memory Impairments Associated with Chronic Visceral Pain: The Role of Cholecystokinin

GRF
2015

Ablation of Lhx15 Gene Expression in Cerebellar Purkinje Cells Delay Peripheral Nervous System Regeneration

GRF
2015

Quantitative Study of Cancer Stem Cells Growth, Migration and Communication with Cancer Cells in a Microfluidic-based Biomimetic Microenvironment

GRF
2015

Elucidating the Functional Significance of the Lrwd1-ORC Interaction

ECS
2015

Dissecting Regulatory Mechanisms Underlying the Poor Prognosis Colon Cancer Subtype

ECS
2015

Development of Self-healable Omniphobic Materials towards Fouling Prevention of Complex Fluids

ECS
2015

RNomics Study of the Emerging Incompatibility Group X3 Plasmid Carrying blaNDM-1 in Hong Kong

HMRF
2015

Lycium barbarum polysaccharides accelerate axonal regeneration: Possible implications for nerve repair

HMRF
2015

Use of Small Chemical Vacuolin-1 as a Novel Anti-Cancer Therapeutic Drug

ITF
2015

pro-siRNA for Highly Potent and Cost-effective RNAi Therapeutics

ITF
2014

Applying a Novel cADPR Photoaffinity Labelling Analogue to Dissect the Cyclic ADP-Ribose (cADPR)-Ca2+ Signaling in Mammalian Cells

GRF
2014

Brain Astrocytes Drive Mood and Cognitive Dysfunction in Chronic Visceral Pain

GRF
2014

Development of Boron Dipyrromethene Based Quenchers as Key Components of Smart Fluorescent Probes for Bioimaging

GRF
2014

Functional analysis of the role of Mcm3 in epigenetic gene silencing

GRF
2014

Investigation of the Molecular Mechanisms of Hsp27 Response to Facilitate Human Enterovirus 71 Infection

GRF
2014

Four Dimensional Live Imaging of Zebrafish Embryos Development Using Light-sheet Microscopy and Biocomputational Tools

CRF
2014

Mechanism of Potentiating HIV Antigen-specific CD8+ T cells

CRF
2014

The Role of AP-4 in the Transcriptional Control of p53 Gene

Donation
2014

Development of Anti-cancer Therapy with Externally Activated Nanomedicine

ITF
2014

How Brain Encodes Memory

Donation

19 October 2022