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Rational Design in Downstream Bioprocessing
Speaker Name
Prof. Dong-Qiang LIN
Speaker Detail

College of Chemical and Biological Engineering
Zhejiang University, China

G4701, 4/F, Yeung Kin Man Academic Building ,City University of Hong Kong, Kowloon Tong, Kowloon, Hong Kong

The improvements in upstream have boosted high productivity in the bio-manufacturing industry, which is shifting the bottlenecks to downstream processing. A multiscale approach of rational design would be introduced to improve the efficiency of downstream bioprocesses. The approach includes four levels: (1) method scale (new separation technology, such as expanded bed absorption, mixed-mode chromatography, continuous chromatography); (2) material scale (novel separation materials, ligands and surface modification); (3) molecule scale (molecular simulation and molecular interactions); (4) process scale (process development and process design). Due to the complexity and particularity of bioprocesses, some model-based software platforms were developed to aid the optimization of operation conditions and guide the process design. In addition, artificial intelligence method was used to improve the data treatment. Multi-scale approach is helpful to understand the microscopic mechanism of bioseparation and optimize the macroscopic performance of downstream processes. Rational design, from molecule to materials, from method to process, would certainly initiate the innovation, improve process efficiency and reduce the manufacturing cost for more sustainable future.

About the Speaker

Dong-Qiang Lin graduated from the Department of Chemical Engineering, Zhejiang University in 1992, and then obtained the PhD in 1997. Since 1998, he work for Zhejiang University, and became a professor at the Department of Chemical and Biological Engineering in 2007. He was the director of the Institute of Bioengineering, Zhejiang University. He also worked as post-doctor at the Institute of Enzyme Technology, Duesseldorf University in 1999-2001, and as the visiting scholar at Stuttgart University (2004.8-10, 2005.6-8), Jacob University Bremen (2009.1-4) and Rensselaer Polytechnic Institute (2014.10-11). Till now he has published more than 150 peer-reviewed papers in international journals and three books, and was authorized 36 patents. He got several technical awards, such as the First Award of Technology Progress (Education Ministry of China), Second Award of Technology Progress (Zhejiang Province, China) ), Second Award of Natural Science (Zhejiang Province, China) and First Award of Technology Progress in High Education (Education Committee of Zhejiang Province of China). In recent year he focused on novel bioseparation technology, separation materials, computer simulation and bioprocess design.