Confined Migration Microfluidic Device for Cell Culture and Drug Screening
The present invention addresses this need by providing a confined migration microfluidic device designed to simulate the restrictive microenvironment for cell migration and enable high-throughput drug screening. The core innovation lies in a microfluidic chip architecture featuring parallel first and second channels connected by multiple identical confined migration channels. These confined channels have a significantly smaller depth (e.g., 4-10 microns) compared to the main channels (e.g., 20-40 microns), creating a physical constriction that mimics in vivo confined spaces.
Prof. YANG Mengsu, Dr. SI Tongxu, Dr. YANG Zihan, Dr ZHOU Zhihang, Mr. ZHOU Zhengdong
-
Microfluidic Chip
-
Cell Culture
-
Drug Screening
-
Biomedical Devices
-
Cell-based Assays
-
Confined migration channels
-
Polydimethylsiloxane
-
Fibronectin
-
High-throughput assay
-
Cancer metastasis research
-
Pharmaceutical screening
-
Tumor microenvironment modeling
-
Diagnostic tools
