The aim of this course is to introduce the state-of-the-art knowledge of rapid diagnostic devices for personalized healthcare. Rapid diagnostic device is an emerging biomedical engineering field which applies materials science, engineering, and physical technologies. This course will provide students with fundamental understanding of basic principles underlying rapid diagnostic devices, develop skills in the areas of biosensors with health monitoring of physiological signals, such as vital signs and molecular information in biofluids, and introduce machine learning to associate specific disease-related physiological information with health conditions for personalized healthcare.