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Dr. YANG Yi (楊屹博士)

BEng (Chu Kochen Honors College, Zhejiang University), MS and PhD (University of Minnesota)

Assistant Professor

Contact Information

Office: G5753 YEUNG
Phone: 34424181
Fax: 34420613
Email: yi.yang@cityu.edu.hk
Web: Personal Homepage

Research Interests

  • Statistical Genetics
  • Knockoff Statistics
  • Bayesian Statistics
  • Machine Learning
  • High-Dimensional Variable Selection
Dr. Yang received a PhD in Biostatistics from the University of Minnesota and a BEng in Management Information Systems from Chu Kochen Honors College, Zhejiang University. Prior to joining CityU, he served as a postdoctoral research scientist in the Department of Biostatistics at Columbia University under the supervision of Professor Iuliana Ionita-Laza. He is also a four-time recipient of the First Prize in the National Olympiad in Informatics (NOI), China.

Dr. Yang's research focuses on variable selection methods for high-dimensional data using knockoff statistics, machine learning, and Bayesian hierarchical models, with applications to genome-wide association studies. He has developed a number of statistical methods to identify risk variants for human diseases in genetic data with complex hierarchical and correlation structures. His research is supported by the Research Grants Council of Hong Kong (RGC) Early Career Scheme 21303323 (sole PI).


Research Grants

  • Statistical methods for variable selection with false discovery rate control and applications to human genetic data, Early Career Scheme (傑出青年學者計劃), Research Grants Council of Hong Kong, 2024 - 2026, Yi Yang (PI).
  • Prediction of patient mortality in intensive care units using machine learning with controlled variable selection, Strategic Interdisciplinary Research Grant, City University of Hong Kong, 2023 - 2025, Linyan Li (PI), Yi Yang (Co-PI).


Publications Show All Publications Show Prominent Publications


Journal

  • Wang, Qi. , Li, Linyan. & Yang, Yi. (2025). Knockoff-ML: A knockoff machine learning framework for controlled variable selection and risk stratification in electronic health record data. npj Digital Medicine. 8. 723 doi:10.1038/s41746-025-02102-2
  • Yang, Yi. , Wang, Qi. , Wang, Chen. , Buxbaum, Joseph. & Ionita-Laza, Iuliana. (2024). KnockoffHybrid: A knockoff framework for hybrid analysis of trio and population designs in genome-wide association studies. American Journal of Human Genetics. 111(7). 1448 - 1461. doi:10.1016/j.ajhg.2024.05.003
  • Yang, Yi. , Wang, Chen. , Liu, Linxi. , Buxbaum, Joseph. , He, Zihuai. & Ionita-Laza, Iuliana. (Oct 2022). KnockoffTrio: A knockoff framework for the identification of putative causal variants in genome-wide association studies with trio design. American Journal of Human Genetics. 109(10). 1761 - 1776. doi:10.1016/j.ajhg.2022.08.013
  • Yang, Yi. , Basu, Saonli. & Zhang, Lin. (Feb 2022). A Bayesian hierarchically structured prior for gene-based association test with multiple traits in genome-wide association studies. Genetic epidemiology. 46(1). 63 - 72. doi:10.1002/gepi.22437
  • Nathan, Jaimie. , Yang, Yi. , Eaton, Anne. , Witkowski, Piotr. , Wijkstrom, Martin. , Walsh, Matthew. , Trikudanathan, Guru. & et, al. (2022). Surgical approach and short-term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: A report from the Prospective Observational Study of TPIAT. Pancreatology. 22 (1). 1 - 8. doi:10.1016/j.pan.2021.09.011
  • Yang, Yi. , Basu, Saonli. & Zhang, Lin. (2021). A Bayesian hierarchically structured prior for rare‐variant association testing. Genetic epidemiology. 45(4). 413 - 424. doi:10.1002/gepi.22379
  • Harindhanavudhi, Tasma. , Yang, Yi. , Hodges, James. , Pruett, Timothy. , Kirchner, Varvara. , Beilman, Gregory. & Bellin, Melena. (2021). Body composition is associated with islet function after pancreatectomy and islet autotransplantation for pancreatitis. The Journal of Clinical Endocrinology & Metabolism. 106 (2). e496 - e506. doi:10.1210/clinem/dgaa790
  • Brennan, Michael. , Treister, Nathaniel. , Sollecito, Thomas. , Schmidt, Brian. , Patton, Lauren. , Yang, Yi. , Lin, Alexander. , Elting, Linda. , Hodges, James. & Lalla, Rajesh. (2021). Epidemiologic factors in patients with advanced head and neck cancer treated with radiation therapy. Head & Neck. 43 (1). 164 - 172. doi:10.1002/hed.26468
  • McEachron, Kendall. , Yang, Yi. , Hodges, James. , Beilman, Gregory. , Kirchner, Varvara. , Pruett, Timothy. , Chinnakotla, Srinath. , Hering, Bernhard. & Bellin, Melena. (2021). Performance of modified Igls criteria to evaluate islet autograft function after total pancreatectomy with islet autotransplantation–a retrospective study. Transplant International. 34 (1). 87 - 96. doi:10.1111/tri.13762
  • Trikudanathan, Guru. , Elmunzer, Joseph. , Yang, Yi. , Abu-El-Haija, Maisam. , Adams, David. , Ahmad, Syed. , Balamurugan, Appakalai. & et, al. (2021). Preoperative ERCP has no impact on islet yield following total pancreatectomy and islet autotransplantation (TPIAT): Results from the Prospective Observational Study of TPIAT (POST) cohort. Pancreatology. 21 (1). 275 - 281. doi:10.1016/j.pan.2020.11.008
  • Yang, Yi. , Basu, Saonli. & Zhang, Lin. (2020). A Bayesian hierarchical variable selection prior for pathway-based GWAS using summary statistics. Statistics in medicine. 39(6). 724 - 739. doi:10.1002/sim.8442
  • McEachron, Kendall. , Yang, Yi. , Hodges, James. , Beilman, Gregory. , Pruett, Timothy. , Kirchner, Varvara. , Dunn, Ty. & et, al. (2020). Alterations in enteroendocrine hormones after total pancreatectomy with islet autotransplantation. Pancreas. 49 (6). 806 - 811. doi:10.1097/MPA.0000000000001582
  • Gutama, Barite. , Yang, Yi. , Beilman, Gregory. , Freeman, Martin. , Kirchner, Varvara. , Pruett, Timothy. & Chinnakotla, Srinath. (2019). Risk factors associated with progression toward endocrine insufficiency in chronic pancreatitis. Pancreas. 48 (9). 1160 - 1166. doi:10.1097/MPA.0000000000001394
  • McEachron, Kendall. , Skube, Mariya. , Yang, Yi. , Hodges, James. , Wilhelm, Joshua. , Beilman, Gregory. , Chinnakotla, Srinath. , Schwarzenberg, Sarah. & Bellin, Melena. (2019). Utility of arginine stimulation testing in preoperative assessment of children undergoing total pancreatectomy with islet autotransplantation. Clinical transplantation. 33 (8). e13647 doi:10.1111/ctr.13647
  • Yang, Yi. , Basu, Saonli. , Mirabello, Lisa. , Spector, Logan. & Zhang, Lin. (2018). A Bayesian gene-based genome-wide association study analysis of osteosarcoma trio data using a hierarchically structured prior. Cancer Informatics. 17. doi:10.1177/1176935118775103
  • Chinnakotla, Srinath. , Verghese, Priya. , Chavers, Blanche. , Rheault, Michelle. , Kirchner, Varvara. , Dunn, Ty. , Kashtan, Clifford. , Nevins, Thomas. , Mauer, Michael. , Pruett, Timothy. , Kim, Youngki. , Najera, Lydia. , Hanna, Christian. , Kizilbash, Sarah. , Cook, Marie. , Cisek, Lars. , Gillingham, Kristen. , Yang, Yi. , Matas, Arthur. & Najarian, John. (2017). Outcomes and risk factors for graft loss: lessons learned from 1,056 pediatric kidney transplants at the University of Minnesota. Journal of the American College of Surgeons. 224 (4). 473 - 486. doi:10.1016/j.jamcollsurg.2016.12.027
  • Wang, Qiuzhen. , Yang, Yi. , Wang, Qi. & Ma, Qingguo. (2014). The effect of human image in B2C website design: an eye-tracking study. Enterprise Information Systems. 8 (5). 582 - 605. doi:10.1080/17517575.2014.925585


Openings

  • I am looking for highly motivated Ph.D. students with a background in statistics, computer science, bioinformatics, data science, or related fields. Please send your CV and transcript(s) to yi.yang@cityu.edu.hk if you are interested. Please see https://yiyangphd.github.io/openings/ for more details.


Last update date : 26 Nov 2025