Prof. Yun Young Go joined City University of Hong Kong in August 2019 as an Assistant Professor in Veterinary Immunology in the Department of Infectious Diseases and Public Health.
Yun Young received both her Doctor of Veterinary Medicine (DVM) and MSc degrees from Konkuk University in Seoul, South Korea. After graduation, she joined the Korea Racing Authority (KRA) as an equine clinician where she gained ample knowledge and experience in equine medicine. Later on, she obtained her PhD degree at Maxwell H. Gluck Equine Research Center, University of Kentucky, USA. Her PhD research project focused on the characterisation of the host immune response and host-virus interactions of the equine arteritis virus. Following the completion of her PhD, she joined the Center for Vaccine Research, University of Pittsburgh, USA, as a postdoctoral scholar working on the antiviral immune response of highly pathogenic viruses, such as Chikungunya and Yellow fever viruses in biosafety level (BSL)-3 and animal BSL-3 facilities. Before joining City University of Hong Kong, she worked at the Korea Research Institute of Chemical Technology, South Korea, as a Senior Research Scientist where she established a productive research programme on the development of antivirals against emerging and re-emerging infectious diseases that are of global public health importance. Yun Young has been a Diplomate of American College of Veterinary Microbiologists since 2011.
Yun Young’s research is mainly focused on studying the interactions between viruses and host defence mechanisms from different perspectives that will eventually converge to design better vaccines and therapeutic options against viral diseases of veterinary and public health importance.
Within this concept, her research interests include:
- Development of therapeutics against emerging and re-emerging viral diseases of humans and animals
- Characterisation of mechanism of action of potential antiviral drug candidates
- Development of small molecule adjuvants to improve the effectiveness of vaccines for humans and animals
- Development of field-deployable diagnostics tests for emerging and re-emerging viral diseases
Prof. Go is currently looking for highly motivated and talented PhD students, research assistants, and postdoctoral fellows with strong interest in the areas of Immunology and Virology. Candidates with expertise in cell and molecular biology, genomics and mouse disease models are encouraged to apply. Interested candidates, please contact Dr. Go (yunygo@cityu.edu.hk) with a cover letter and a full CV
Please see Google Scholars for a full list of publications.
Jung E, Nam S, Oh H, Jun S, Ro HJ, Kim B, Kim M, Go YY.
Neutralization of acidic intracellular vesicles by niclosamide inhibits multiple steps of the dengue virus life cycle in vitro.
Sci. Rep. (2019) Jun 18; 9(1):8682. DOI: 10.1038/s41598-019-45095-1
Jung E, Lee JY, Kim HJ, Ryu CK, Lee KI, Kim M, Lee CK, Go YY.
Identification of quinone analogues as potential inhibitors of picornavirus 3C protease in vitro.
Bioorg Med Chem Lett. (2018) Aug 1;28(14):2533-2538. DOI: 10.1016/j.bmcl.2018.05.046
Shin JS, Jung E, Kim M, Baric RS, Go YY.
Saracatinib inhibits Middle East respiratory syndrome-coronavirus replication in vitro.
Viruses (2018) May 24;10(6). pii: E283. DOI: 10.3390/v10060283
Go YY, Kim YS, Cheon S, Nam S, Ku KB, Kim M, Cho NH, Park H, Alison Lee PY, Lin YC, Tsai YL, Thomas Wang HT, Balasuriya UBR.
Evaluation and clinical validation of two field-deployable reverse transcription-insulated isothermal PCR assays for the detection of the Middle East respiratory syndrome-coronavirus.
J Mol Diagn. (2017) Nov;19(6):817-827. DOI: 10.1016/j.jmoldx.2017.06.007
Carossino M, Loynachan AT, Canisso IF, Cook RF, Campos JR, Nam B, Go YY, Squires EL, Troedsson MHT, Swerczek T, Del Piero F, Bailey E, Timoney PJ, Balasuriya UBR.
Equine arteritis virus has specific tropism for stromal cells and CD8+ T and CD21+ B lymphocytes but not for glandular epithelium at the primary site of persistent infection in the stallion reproductive tract.
J Virol. (2017) Jun 9;91(13). pii: e00418-17. DOI: 10.1128/JVI.00418-17
Kumar V, Shin JS, Shie JJ, Ku KB, Kim C, Go YY, Huang KF, Kim M, Liang PH.
Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors.
Antiviral Res. (2017) May;141:101-106. DOI: 10.1016/j.antiviral.2017.02.007
Sarkar S, Bailey E, Go YY, Cook RF, Kalbfleisch T, Eberth J, Chelvarajan RL, Shuck KM, Artiushin S, Timoney PJ, Balasuriya UB.
Allelic variation in CXCL16 determines CD3+ T lymphocyte susceptibility to equine arteritis virus infection and establishment of long-term carrier state in the stallion.
PLoS Genet. (2016) Dec 8;12(12):e1006467. DOI: 10.1371/journal.pgen.1006467
Go YY, Rajapakse RPVJ, Kularatne SAM, Lee PA, Ku KB, Nam S, Chou PH, Tsai YL, Liu YL, Chang HG, Wang HT, Balasuriya UBR.
A pan-dengue virus reverse transcription-insulated isothermal PCR assay intended for point-of-need diagnosis of dengue virus infection by use of the POCKIT nucleic acid analyzer.
J Clin Microbiol. 2016 Jun;54(6):1528-1535. DOI: 10.1128/JCM.00225-16
Sarkar S, Bailey E, Go YY, Cook RF, Kalbfleisch T, Eberth J, Chelvarajan RL, Shuck KM, Artiushin S, Timoney PJ, Balasuriya UB.
Equine arteritis virus uses equine CXCL16 as an entry receptor.
J Virol. 2016 Jan 13;90(7):3366-84. DOI: 10.1128/JVI.02455-15