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Methods and Kits for Detecting Exosomal Protein
This patent introduces an innovative method for detecting exosomal proteins, such as monocarboxylate transporter 1 (MCT1) and cluster of differentiation 147 (CD147), using a combination of localized surface plasmon resonance (LSPR) and atomic force microscopy
Prof. LEE Youngjin, Prof. WU Lawrence, Dr. THAKUR Abhimanyu, Dr. QIU Guangyu, Dr. NG Siu Pang, Dr. XU Chen, Dr. YANG Tian
  • Exosomal Protein Detection
  • Localized Surface Plasmon Resonance
  • Atomic Force Microscopy
  • Nanostructured Biosensor
  • Antibody-functionalized Probe
  • Self-assembly Gold Nanoislands
  • Glioma Diagnosis
  • Non-invasive Biomarker Detection
  • Cancer Progression Monitoring
  • Liquid Biopsy
  • Metabolic Reprogramming Analysis
TRL
4
Sensor for Liquid Biopsy and Its Method of Making, and Method of Non-Invasive Liquid Biopsy
The invention involves the precise detection of enhanced exosomal CD44 by sensitive non-invasive titanium nitride (TiN) nanoholes- localized surface plasmon resonance (TiN-NH-LSPR) - and TiN-NH discs immunocapture- atomic force microscopy (TIC-AFM) biosensors, demonstrating this may be a promising liquid biopsy method in both detecting the malignant transition of GMs and potentially determining the therapeutic efficacy of anti-glioma agents.
Prof. LEE Youngjin, Prof. WU Lawrence, Dr. THAKUR Abhimanyu, Dr. NG Siu Pang, Dr. XU Chen
  • Biomarker Cancer
  • Diagnostics
  • Exosome Detection
  • Glioma Cells
  • Liquid Biopsy
  • Cancer Diagnosis
  • Cancer Therapy
  • Exosome Research
  • Nanovesicle Research
TRL
4
A Method of Isolating And Detecting Exosomal Biomarkers of Glioblastoma Malignancy
In this invention, atomic force microscopy (AFM) and localized surface plasmon resonance (LSPR) biosensors have been applied to prove the detection feasibility of GBM-derived exosomal biomarkers CD 44 and CD133 in vivo.
Prof. LEE Youngjin, Dr. THAKUR Abhimanyu, Dr. LI Wing Kar
  • Glioblastoma
  • Exosomes
  • CD44 and CD133
  • Lactate
  • Atomic Force Microscopy
  • LSPR Biosensors
  • Central Nervous System
  • Liquid Biopsy
  • Malignant Glioma Progression
  • Diagnosis and Prognosis
TRL
5

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