Prof. Ying Li (李嬰教授)

MD (Beijing), FAGA (US)

Professor

Prof. Ying Li

Contact Information

Office: P6322, Yeung Kin Man Academic Building
Phone: +852 3442-2669 / 5396-1501
Fax: +852 3442-0549
Email: yingli@cityu.edu.hk
Web: CityU Scholars

Research Interests

  • Central nervous system sensitization and synaptic plasticity
  • Brain target for chronic pain
  • Learning and memory
  • Sensory signal transduction in the vagal primary afferent neurons
  • Animal models of neurogenic disorders

Ying Li, M.D. was educated in Beijing medical University (1962–1968). He was a general surgeon at the Qinghai, and oral-maxillofacial surgeon at Nanjing Medical School, China. He completed post-doctoral fellowship in department of internal medicine Hypertension, University Michigan, and then joined Gastroenterology, where he was appointed Assistant Research Scientist in 1997, and Associate Research Professor in the University of Michigan Medical School Department of Internal Medicine in 2002. Professor Li joined Department Biomedical Science City University of Hong Kong in December 2009.

Li is Fellow American Gastroenterological Association, Honors Professor Faculty of Dentistry Hong Kong University, Honors Investigator Shenzhen Institutes of Advanced Technology Brain Research Institute, CAS.

Dr. Li Ying's research interests focus on brain targets for chronic pain. A major goal of his work is to characterize chronic pain associated synaptic metaplasticity that lead to emotional and cognitive disturbances. By combining large-scale neural recordings and optogenetics in free moving animals, Li and his colleagues investigate the disruptions of anterior cingulate cortex phase-locking and ACC network information flow during learning-memory tasks and decision making in rats. Li’s current studies on glial cells are designed to determine how astrocytic L-lactate signaling facilitates amygdala-ACC synchrony and decision-making. These studies have begun to elucidate that the large spatial domain over which astrocytes can couple and regulate neuronal network activity is the fundamental element for mediating cognition. The 'astrocyte-neuronal L-lactate shuttle' pathway may provide therapeutic intervention for cognitive improvement in chronic pain. Currently, his team are studying on the mechanism of brain myelination for determining optimal synchrony of spike‑time arrival which is of fundamental importance in schematic learning and consolidation. Li's research also relates to the physiology and function of the vagus nerve. He seeks to understand how cholecystokinin-8, a gastrointestinal hormone released during feeding that acts on the vagal afferent enables the rescue of memory deficits, further repairs theta-phase-locking of ACC neurons and maintains the synchrony in ACC neural network in chronic pain state.

Li was the principle investigator for US National Institutes of Health RO1 DK51717 (1997-2007), and US National Institute of Neurological Disorders and Stroke RO1 NS051466 (2006-2010). His current research works are supported by GRF, NSFC/UGC, HMRF and ITF.

Total no. of citations: 2498, H-index: 33; indeed, Li is the first or correspondence author of 88% of his publications.

GRANT SUPPORT

PRESENT AND ACTIVE

Role on project: Principal Investigator

  1. Title: L-lactate Release by Optogenetic Activation of Astrocytes Rescues Decision-making Deficit in Visceral Hypersensitive Rats
    CityU Project No: 9054021
    Funding Sponsor: NSFC/RGC Joint Research Scheme 2017-18, approval date 11/2017
    01/01/2018–31/12/2021
  2. General Research Fund (GRF) 11166116. City U 9042320
    Vagus nerve stimulation modulates neuronal spike field phase locking and synchrony cross areas associated with facilitation of decision-making in rats.
    1/2017–12/2018
  3. GRF Project Number: 11100914 CityU No 9042020 PI
    Title: Brain astrocytes drive mood and cognitive dysfunction in chronic visceral pain
    Project Period: 1/2015–6/2018
  4. GRF 11101315 CityU 9042170
    Targeting vagal afferent in learning and memory impairments associated with chronic visceral pain: the role of cholecystokinin
    Project Period:1/2016–12/2018
  5. HMRF 05160256
    Impaired communications in anterior cingulate cortex neural network in the rats with trigeminal neuropathic pain is associated with decision-making deficits
    Project Period: 1 Aug 2018 to 31 Jul 2020
  6. Center for biosystems, Neuroscience, and Nanotechnology Deputy Director
    Funding Sponsor: City University

MAJOR PREVIOUS FUND

Role on project: Principal Investigator

  • GRF 160713, CityU 9041947 Project Period: 1/2014–12/2016
    Title: Brainstem–cortex synaptic plasticity in the trigeminal neuropathic pain
  • GRF CityU 9041728 160811
    Title: Vagal afferent neuronal plasticity: implication in the emesis related to chemotherapy
    Period: 1/2012 to 1/6/2015
  • GRF, 9041625 City U 160810 Project Period: 1/2011–6/2014
    Title: Thr286 phosphorylated αCaMKII in anterior cingulate cortex mediates visceral pain in visceral Hypersensitive state.
  • GRF Grant: 160812 City U 9041853
    Project Period: 1/2013–6/2016
    Title: The prefrontal cortex as a key target of the visceral pain processing in adult rats following maternal separation stress in infancy
    Role on project: Principal Investigator
  • Health and Medical Research Fund (HMRF) CityU 9211056
    Title: Sensitization of anterior cingulate cortex, upregulation of NR2B receptors and astroglial glutamate–glutamine shuttle contribute to pain responses in rats with chronic pancreatitis
    Project Period: 4/2014–3/2016
  • Innovation and Technology Fund (ITF) HK ITS/300/15; 9440155
    CityU internal Project No: 9678127
    Title: Neural Probes with Flexible and Floating Microelectrode Arrays to Study the Mechanisms of Decision-making by Vagus Nerve Stimulation in Rats
    1/8/2016–31/1/2018
  • Shenzhen Knowledge Innovation Program on Basic Research Project
    急性及慢性蓄积性雪卡中毒对大鼠脑神经元、胶质细胞和脑认知功能损害的研究
    Project Period: 1/2014–12/2016
    Funding Sponsor: National Institute of Neurological Disorders and Stroke
  • Grant: RO1 NS051466
    Project Period: 1/15/2006–12/30/2010
    Title: Anterior cingulate cortex sensitization in visceral hypersensitive rats
    Role on project: Principal Investigator
    Funding Sponsor: National Institutes of Health
  • Grant: RO1 DK51717
    Project Period: 09/01/1997–06/30/2007
    Title: Vagal neurotransmission evoked by 5HT-dependent luminal factor
    Role on project: Principal Investigator
  • NSFC: 81170353 CityU internal project 9680020
    Title: Vagal stimulation modulate visceral pain 刺激迷走传入神经抑制内脏痛
    Project Period: 1/2012–12/2015
    Role on project: Principal Investigator
  • GRF, CityU 160812 CityU internal project No 9041853 PI
    Project Period: 1//2013–6/2016
    Title: The prefrontal cortex as a key target of the visceral pain processing in adult rats following maternal separation stress in infancy
    Role on project: Principal Investigator
  • Health and Medical Research Fund (HMRF) No 9211056 CityU 01122006
    Title: Sensitization of anterior cingulate cortex, upregulation of NR2B receptors and astroglial glutamate–glutamine shuttle contribute to pain responses in rats with chronic pancreatitis
    Project Period: 4/2014–3/2016

15 Selected Peer-Reviewed J Publications

Total no. of citations: 2498, H-index: 33; indeed, Li is the first or correspondence author of 88% of his publications

  1. J Wang, J Tu, B Cao, Li M, X Yang, MiCong, Aruna S. R, Rosa H. M. Chan, ,L Wang, and. Ying Li.* Astrocytic L-lactate Signaling Facilitates Amygdala-Anterior Cingulate Cortex Synchrony and Decision-making in Rats. Cell Reports. 2017
    https://www.sciencedirect.com/science/article/pii/S2211124717316327?via%3Dihub
  2. B Cao; J Wang; X Zhang; X Yang; D Poon; B Jelfs. R. Chan; J Wu, Ying Li*. Impairment of Decision Making and Disruption of Synchrony between Basolateral Amygdala and Anterior Cingulate Cortex in the Maternally Separated Rat. Neurobiology of Learning and Memory. 136 (2016) 74–85
  3. B Cao; J Wang; L Mu; D Poon Y Li* Impairment of Decision Making Associated with Disruption of Phase-Locking in the Anterior Cingulate Cortex in Viscerally Hypersensitive Rats. Experimental Neurology 136 (2016) 74–85
  4. Bing Cao Jun Wang, Mahadi Shahed, Beth Jelfs, Rosa H. M. Chan & Ying Li*, Vagus Nerve Stimulation Alters Phase Synchrony of the Anterior Cingulate Cortex and Facilitates Decision Making in Rats. Scientific Reports 6:35135 DOI: 10.1038/srep35135. 2016
  5. J Wang, X Zhang, B Cao, J Liu, Ying Li*. Facilitation of synaptic transmission in the anterior cingulate cortex in the viscerally hypersensitive rats Cerebral Cortex 2013; doi: 10.1093/cercor/bht273.
  6. Ying Li*, X Zhang, H Yai, Z Cao, S Chen, B Cao. Phosphorylated CaMKII postsynaptic binding to NR2B subunits in the anterior cingulate cortex mediates visceral pain in visceral hypersensitive rats. J Neurochemistry, 1111/j.1471-4159. 2012
  7. X Wu, J Gao, Jin Yan, J Fan, C Owyang, Ying Li*. Role for NMDA receptors in visceral nociceptive transmission in the anterior cingulate cortex of viscerally hypersensitive rats. Am J Physiol. 294:G918-G927, 2008
  8. Cao, Z., Wu, X., Chen, S, C Owyang, Y Li*. Anterior cingulate cortex modulates visceral pain as measured by visceromotor responses in viscerally hypersensitive rats, Gastroenterology. 134:535-543, 2008.
  9. J Fan, X Wu, Z Cao, S Chen, C Owyang, and Ying Li*. Upregulation of anterior cingulate cortex NR2B receptors contributes to visceral pain as measured by visceromotor responses in rats. Gastroenterology 136:1732–1740,2009.
  10. Ying Li*. Sensory signal transduction in the vagal primary afferent neurons. Current Medicinal Chemistry, 2007, 14, 2552-2563
  11. Gao J, X Wu, C Owyang, Ying Li*. Enhanced response of the anterior cingulate cortex to colonic distension in viscerally hypersensitive rats. J Physiolog (Lond). 570 (1):169-184, 2006.
  12. 12. Ying Li, Hao Y, Owyang C. Diazepam-binding inhibitor mediates feedback regulation of pancreatic secretion and postprandial release of cholecystokinin. Journal of Clinic Investigation 105:351-359, 2000.
  13. Zhu JX, Wu XY, Owyang C, Ying Li*. Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat. J of Physiol (Lond), 2001, 530 (3): 431-442. 2001.
  14. Ying Li, Owyang C. Peptone stimulates CCK-releasing peptide secretion by activating intestinal submucosal cholinergic neurons. Journal of Clinic Investigation 97:1463-1470, 1996.
  15. Ying Li, Owyang C. Vagal afferent pathways mediate physiological action of cholecystokinin on pancreatic secretion. Journal of Clinic Investigation 92:418-424, 1993