Dr Sungchil Yang achieved PhD in the department of molecular and integrative physiology, University of Illinois at Urbana & Champaign, studying a biophysical role of individual auditory neurons (from cochlear nucleus to auditory cortex) in auditory information processing under the supervision of Dr Albert S. Feng. Then, Dr Yang joined Helen Wills Neuroscience Institute of University of California at Berkeley as a postdoctoral fellow, studying mechanisms of an auditory phantom pain, tinnitus, with Dr Shaowen Bao. His research regarding the sensory system continued in Center for Integrative Neuroscience of University of California at San Francisco as a research associate, studying a role of axon initial segment of auditory neurons in information processing and a cellular basis of perceptual learning with Dr Kevin J. Bender and Christoph E. Schreiner, respectively. Then, he joined the Department of Biomedical Science in City University of Hong Kong.
A fundamental question in neuroscience is how a neuron processes innate and environmental cues in order to produce behaviorally relevant outputs. The several hypotheses how the inputs are stored, adapted, and learned in our brain have been proposed, yet their working models remain to be explored. For this, we study both the auditory systems (for mechanistic understanding of sensory learning process) and hippocampus (for cellular mechanisms of brain memory operation). Toward this end, we are performing 3D digital holography, two-photon imaging, voltage-sensitive dye imaging, and in vivo whole-cell recording. With these modern techniques, our research will reveal how our brain optimally captures and modifies information. This research will be eventually applied to cure information processing disorders embedded in several brain diseases such as autism, depression, schizophrenia, epileptic seizure, neuropathic pain, and tinnitus.
Hannah TETTEH, PhD student, firstname.lastname@example.org
Gona CHOI, PhD student, email@example.com
Rebecca So Jeong PAK, PhD student, firstname.lastname@example.org
Jihwan LEE, PhD student, email@example.com
Ching Yi SZE, Research Assistant, firstname.lastname@example.org
Minseok LEE, Research Assistant, email@example.com
Asher Chin Ho DAI, undergraduate RA, firstname.lastname@example.org
Han Nah CHOI, undergraduate RA, email@example.com
Selected Publication (* co-first author, # corresponding author)
- Park SW, Kim J, Kang M, Lee W, Park BS, Kim H, Choi SY, Yang S#, Ahn JH#, Yang S# (2018) Epidural electrotherapy for epilepsy. Small (June 27) doi:10.1002/smll.201801732
- Yang S, Chung J, Jin SH, Bao S#, Yang S# (2018) A circuit mechanism of time-to-space conversion for perception. Hearing Research (May 17) doi: 10.1016/j.heares.2018.05.008.
- Sun D, Kang H, Tetteh H, Su J, Lee J, Park S, He J, Jo J, Yang S#, and Yang S# (2018) Long term potentiation, but not depression, in interlamellar hippocampus CA1. Scientific Reports (Mar 26) doi: 10.1038/s41598-018-23369-4
- Tetteh H, Lee M, Lau CG, Yang S, and Yang S# (2017) Tinnitus: Prospects for pharmacological interventions with a seesaw model. The Neuroscientist (Oct 9) doi: 10.1177/1073858417733415
- Yang S, Santos MD, Tang C, Kim JG, and Yang S# (2016) A postsynaptic role for short-term neuronal facilitation in dendritic spines. Front. Cell. Neurosci. (Sep 30) 10:224 doi: 10.3389/fncel.2016.00224
- Yang S, Ben-shalom R, Ahn M, Liptak AT, van Rijn RM, Whistler JL and Bender KJ (2016) β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment. Cell Reports (Aug 9) 16, 1–9 doi: 10.1016/j.celrep.2016.06.098
- Yang S, Tang CM and Yang S (2015) The shaping of two distinct dendritic spikes by A-type voltage-gated K+ channels. Frontiers in Cellular Neuroscience (Dec 09) 9:469 doi: 10.3389/fncel.2015.00469
In the Past
- Yang S*, Yang S*, Moreira T, Hoffman G, Garlson GC, Bender KJ, Alger BE, and Tang CM (2014) Inter-lamellar CA1 network in the hippocampus. Proceedings of the National Academy of Sciences (Sep 02) 111(35): 12919-12924. * Equal contribution
- Yang S, Yang S, Park JS, Kirkwood A, and Bao S (2014) Impaired long-term potentiation in the developing auditory cortex of fmr1 knockout mice. PloS One (Aug 12) 9(8): e104691.
- Yang S, Zhang LS, Gibboni R, Weiner BD, and Bao S (2014). Impaired development and competitive refinement of cortical frequency map in tumor necrosis factor-α deficient mice. Cerebral Cortex (Jul 01) 24(7): 1956-65.
- Yang S#, and Bao S (2013). Homeostatic mechanism and treatment of tinnitus. Restorative Neurology and Neuroscience (Mar 01) 31(2):99-108.
- Yang S, Su W, and Bao S (2012). Long-term, but not transient, hearing loss alters the morphology and increases the excitability of cortical pyramidal neurons. J Neurophysiol (Sep 15) 108:1567-1574.
- Yang S#, Yang S, Cox CL, Llano DA, and Feng AS (2012). Cell’s intrinsic biophysical properties play a role in the systematic decrease in time-locking ability of central auditory neurons. Neuroscience (Apr 19) 208: 49-57.
- Yang S, Weiner BD, Zhang LS, Cho SJ, and Bao S (2011). Homeostatic plasticity drives tinnitus perception in an animal model. Proceedings of the National Academy of Sciences (Sep 06) 108: 14974-14979.
- Yang S#, Lin WY, and Feng AS (2009). Wide-ranging frequency preferences of auditory midbrain neurons: Roles of membrane time constant and synaptic properties. Eur J Neurosci (Jul 01) 30: 76-90.
- Yang S#, and Feng AS (2007). Heterogeneous biophysical properties of frog dorsal medullary nucleus (Cochlear Nucleus) neurons. J Neurophysiol (Oct 01) 98: 1953-1964.
- Yang S, Lee DS, Chung CH, Cheong MY, Lee CJ, and Jung MW (2004). Long-term synaptic plasticity in deep layer-originated associational projections to superficial layers of rat entorhinal cortex. Neuroscience (Jul 27) 127(4):805-12.