City University of Hong Kong-HK

Dr Christina TO

B.Sc. (Biochemistry), M.Phil. (Biochemistry), M.Sc. (Quality Management), PhD (Pathology), HKIMLS (member), HKSMDS (member)
Registered MLT Part 1

Molecular Biology Scientific Officer

Contact Information
Address:  Veterinary Diagnostic Laboratory,
Y1710, Bay 1, Yellow Zone, Academic Building 1,
City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong
Phone: 3442-4771
Fax: 3442-0819
Email: christina.to@cityu.edu.hk
Public CV:  Download

Dr. Christina TO is a Molecular Biology Scientist experienced in molecular diagnostic and serology testing. She has more than 8 years of clinical diagnostic and supervisory experiences in Molecular Pathology and Immunology, performing various molecular diagnostic and immunology tests, especially in the field of infectious disease. In addition to clinical experience, she has more than 8 years research experiences in Molecular, Immunology and Cell Biology.

After graduating with a Bachelor of Science degree in Biochemistry from the Chinese University of Hong Kong, she continued to pursue her M.Phil.'s studies in the same University. Her M.Phil.'s project was about the role of intracellular calcium in TNF-alpha-induced C6 glioma cell proliferation.

This was followed by research works in the Chinese University of Hong Kong and the University of Hong Kong. Her major fields of interest were cancer and immunology.

Afterwards, she was awarded her PhD degree in Pathology from the University of Hong Kong. Her PhD's project was 'Dendritic cell-based tumor vaccine' in which she used molecular techniques to modify the dendritic cells to act as a vaccine against melanoma.

She then continued to develop her career in the cancer research field with postdoctoral training in the Hong Kong Polytechnic University and she was responsible for the project 'Anti-tumor efficacy of Arginase'.

For the past 8.5 years she worked in a commercially-owned molecular diagnostic pathology laboratory, performed molecular diagnostic and immunology tests and managing the laboratory accreditation programme. She obtained her M.Sc. degree in Quality Management from the Hong Kong Polytechnic University to enrich her knowledge in quality assurance and laboratory accreditation.

She is currently a registered MLT Part 1 and is an ordinary member in HKIMLS as well as HKSMDS.

Publications

  • Ng MH, To KW, Lo KW, Chan S, Tsang KS, Cheng SH, Ng HK (2001)
    Frequent death-associated protein kinase promoter hypermethylation in multiple myeloma.
    Clin Cancer Res. 7:1724-9.

  • Ng MH, Lau KM, Wong WS, To KW, Cheng SH, Tsang KS, Chan NP, Kho BC, Lo KW, Tong JH, Lam CW, Chan JC (2003).
    Alterations of RAS signalling in Chinese multiple myeloma patients: absent BRAF and rare RAS mutations, but frequent inactivation of RASSF1A by transcriptional silencing or expression of a non-functional variant transcript.
    Br J Haematol. 123:637-45.

  • Ma L, Chan KW, Trendell-Smith NJ, Wu A, Tian L, Lam AC, Chan AK, Lo CK, Chik S, Ko KH, To CK, Kam SK, Li XS, Yang CH, Leung SY, Ng MH, Stott DI, MacPherson GG, Huang FP (2005).
    Detection of Chlamydia pecorum in joints trimmed from ovine carcases with arthritis at an abbatoir in southern Australia. Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains.
    Eur J Immunol. 35:3364-75

  • Huang FP, Chen YX, To CK. (2011).
    Guiding the "misguided" - functional conditioning of dendritic cells for the DC-based immunotherapy against tumours.
    Eur J Immunol. 41:18-25.