Dr. Peggy P K Lo

PhD (McGill)

Assistant Professor of Department of Chemistry

Contact Information

Office:   AC1-B6523
Phone:   +852 3442-7840
Fax:        +852 3442-0522
Email:    peggylo@cityu.edu.hk
Web:      Personal Homepage

Research Interests

  • Chemical Biology
  • DNA Chemistry
  • Synthetic Chemistry
  • Biomimetics
  • Biomolecular Sensing
  • Bioimaging

Dr. Peggy Lo received her B.Sc (2004) and M.Phil. (2006) from Hong Kong Baptist University. In 2010, she obtained a Ph.D. in DNA Chemistry from McGill University in Canada. Her Ph.D research focuses on supramolecular chemistry using DNA as a scaffold to build nanotubes and creation of well-defined DNA-mimetic polymers under the supervision of Professor Hanadi F. Sleiman. She then moved to the United States for her postdoctoral research at Harvard University with Professor Hongkun Park from 2010 to 2012. She joined City University of Hong Kong in July 2012.

Her current research interests include design and assembly of bio-inspired DNA-based nanostructures, which are used to address problems in life science and nanomaterials.

Creation of Bio-inspired DNA-based nanostructures
Deliver the well-designed and artificial DNA-based nanostructures to live cells and study their biological functionalities such as targeted delivery of molecular cargo (e.g drugs or proteins) to specific sites in cancer cells, and gene knockdown in a disease cell, etc.

DNA-based nanoelectronics or nanophotonics
Template/position nano-sized components such as nanoparticles, chromophores, electron donors, acceptors and catalytic centers to access light-harvesting devices for solar energy conversion into chemical energy, and precisely pattern memory, and other electronic components for data storage.

Biomolecular sensing and bioimaging
Determine the concentrations of diverse biomolecules in real time at single cell level for eventual use as a medical diagnostic tool, and analyze protein assemblies in biological pathways.

A second active area in her group is design and synthesis of advanced materials such as nanoparticles, small molecules and polymers for medical and bioanalytical research and applications.

Publications

After joining CityU:

  • R.Chen, J. Zhang, J. Chelora, Y. Xiong, S. Kershaw, K. F. Li, P. K. Lo, K. W. Cheah, A. L. Rogach, J. A. Zapien, C. S. Lee.  “Ruthenium (II) Complex Incorporated UiO-67 Metal-Organic Frameworks Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy” ACS Applied Materials & Interfaces 2017, Accepted.
  • Z. Dai, H. M. Leung, P. K. Lo. “Stimuli-Responsive Self-Assembled DNA Nanomaterials for Biomedical Applications” Small 2017 in press, dox: 10.1002/smll.201602881.
  • Z. Dai, Q. Gao, M. C. Cheung, H. M. Leung, T. C. K. Lau, H. F. Sleiman, K. W. C. Lai, P. K. Lo. “A Highly Versatile Platform Based on Geometrically Well-Defined 3D DNA Nanostructures for Selective Recognition and Positioning of Multiplex Targets” Nanoscale 2016, 8, 18291-18295.
  • M. S. Chan, D. Y. Tam, Z. Dai, L. S. Liu, J. W. Ho, M. L. Chan, D. Xu, M. S. Wong, C. Tin, P. K. Lo. “Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers” Small 2016, 12, 770-781.
  • W. Liu, L. Liang, P. K. Lo, X. J. Gou, X. H. Sun. “A Double Branched Photosensitive Prodrug:Synthesis and Characterization of Light Triggered Drug Release” Tetrahedron Lett. 2016, 57, 959-963.
  • Z. Wang, D. Y. Tam, A. S. Susha, M. S. Chan, S. V. Kershaw, P. K. Lo, A. L. Rogach. “Aggregation-Free DNA Nanocages/Quantum Dot Complexes Based on Electrostatic Adsorption” Colloids and Surfaces A: Physicochem. Eng. Aspects 2016, 495, 62-67.
  • D. Y. Tam, Z. Dai, M. S. Chan, L. S. Liu, M. C. Cheung, F. Bolze, C. Tin, P. K. Lo.A Reversible DNA Logic Gate Platform Operated by One- and Two-Photon Excitations” Angew. Chem. Int. Ed. 2015, 55, 164-168.
  • S. Chen., L. T. Chu, P. P. Yeung, Z. Zhao, Y. Bao, M. S. Chan, P. K. Lo, T. H. Chen. “Enzyme-Free Amplification by Nano Sticky Balls for Visual Detection of ssDNA/RNA Oligonucleotides”ACS Applied Materials & Interfaces 2015, 7, 22821-22830.
  • M. S. Chan, D. Xu, L. Guo, D. Y. Tam, L. S. Liu, Y. Chen, M. S. Wong, P. K. Lo. “Cyanine Fluorophore for Cellular Protection against ROS in Stimulated Macrophages and Two-Photon ROS Detection” Org. Biomol. Chem. 2015, 13, 7307-7312.
  • Z. Dai, D. Y. Tam, H. Xu, M. S. Chan, L. S. Liu, F, Bolze, X. H. Sun, P. K. Lo. “Conformational Change of Self-Assembled DNA Nanotubes Induced by Two-Photon Excitation” Small 2015, 11, 4090-4096.
  • L. Guo, M. S. Chan, D, Xu, D. Y. Tam, F. Bolze, P. K. Lo, M. S. Wong. “Indole-based Cyanines as a Nuclear RNA-Selective Two-Photon Fluorescent Probe for Live Cell Imaging”. ACS Chem. Bio. 2015, 10, 1171-1175.
  • D. Y. Tam, P. K. Lo. “Multifunctional DNA Nanomaterials for Biomedical Applications”. J. Nanomater. Vol. 2015, Article ID 765492, 21 pages, 2015.
  • O. Sushkov, N. Chisholm, I. Lovchinsky, M. Kubo, P. K. Lo, S. D. Bennett, D. Hunger, A. Akimov, R. L. Walsworth, H. Park,* M. D. Lukin.* All-optical sensing of a single-molecule electron spin”. Nano Lett. 2014, 14, 6443-6448.
  • M. S. Chan, P. K. Lo. “Nanoneedle-Assisted Delivery of Site-Selective Peptide-Functionalized DNA Nanocages for Mitochondria and Nucleus Targeting” Small 2014, 10, 1255-1260.
  • D. Liu, C. Yi, K. Wang, C. C. Fong, Z. Wang, P. K. Lo, D. Sun, M. S. Yang. “Reorganization of Cytoskeleton and Transient Activation of Ca2+ Channels in Mesenchymal Stem Cells Cultured on Silicon Nanowire Arrays” ACS Applied Materials & Interfaces 2013, 5, 13295-13304.
  • G. Kucsko, P. C. Maurer, N. Y. Yao, M. Kubo, H. J. Noh, P. K. Lo, H. Park, and M. D. Lukin. “Nanometer- Scale Thermometry in a Living Cell” Nature 2013, 500, 54-59.
  • W. Yang, P. S. Chan, M. S. Chan, K. F. Li, P. K. Lo, N. K. Mak, K. W. Cheah, M. S. Wong.Two-photon fluorescence probes for imaging of mitochondria and lysosomes” Chem. Commun. 2013, 49, 3428-3430.
  • W. Yang, Y. Chen, M. S. Wong, P. K. Lo. “Reinforced Self-assembly of Donor-Acceptor π-Conjugated Molecules to DNA Templates by Dipole-Dipole Interactions Together with Complementary Hydrogen Bonding Interactions for Biomimetics. Biomacromolecules 2012, 13, 3370-3376. 

Before joining CityU:

  • C. K. Ho, S. Y. Poon, P. K. Lo, M. S. Wong , W. Y. Wong. “Synthesis, Characterization and Photophysical Properties of Metallopolyynes and Metallodiynes of Platinum(II) with Dibenzothiophene Derivatives”. Journal of Inorganic and Organometallic Polymers and Materials 2013, 23, 206-215.
  • D. R. Glenn, H. Zhang, N. Kasthuri, R. Schalek, P. K. Lo, A. S. Trifonov, H. Park, J. W. Lichtman, R. L. Walsworth. " Correlative Light and Electron Microscopy Using Cathodoluminescence from Nanoparticles with Distinguishable Colours” Scientific Reports, 2012, 2, 865.
  • H. Yan, A. Florian, D. A. deBruijn, C. K. McLaughlin, P. K. Lo, H. F. Sleiman. “Chiral Metal-DNA Four-Arm Junctions and Metalated Nanotubular Structures”. Angew. Chem. Int. Ed. 2011, 50, 4620-4623.
  • P. K. Lo, P. Karam, F. A. Aldaye, C. K. McLaughlin, G. Hamblin, G. Cosa, H. F. Sleiman. “Loading and Selective Release of Cargo in DNA Nanotubes with Longitudinal Variation”. Nature Chemistry 2010, 2, 319-328.
  • P. K. Lo, K. Metera, H. F. Sleiman. “Self-Assembly of Three-Dimensional DNA Nanostructures and Potential Biological Applications”. Current Opinion in Chemical Biology 2010, 14, 597-607.
  • P. K. Lo, F. Altvater, H. F. Sleiman. “Templated Synthesis of DNA Nanotubes with Controlled, Predetermined Lengths”. Journal of the American Chemical Society 2010, 132, 10212-10214.
  • Y. Wen, C. K. McLaughlin, P. K. Lo, H. Yang, H. F. Sleiman. “Stable Gold Nanoparticle Conjugation to Internal DNA Positions: Facile Generation of Discrete Gold Nanoparticle-DNA Assemblies”. Bioconjugate Chemistry 2010, 21, 1413-1416.
  • P. K. Lo, H. F. Sleiman. “Nucleobase-Templated Polymerization: Copying the Chain Length and Polydispersity of Living Polymers into Conjugated Polymers”. Journal of the American Chemical Society 2009, 131, 4182-4183.
  • F. A. Aldaye, P. K. Lo, P. Karam, C. K. McLaughlin, G. Cosa, H. F. Sleiman. “Modular Construction of DNA Nanotubes with Readily Tunable Geometry, Rigidity, and Single- or Double-Stranded Character”. Nature Nanotechnology 2009, 4, 349-352.
  • P. K. Lo, F. A. Aldaye, H. F. Sleiman. “Modular Construction of DNA Nanotubes of Tunable Geometry, Alternating Size, and Single- or Double-Stranded Character”. Journal of Biomolecular Structure & Dynamics 2009, 26, 801.
  • Z. Q. Gao, P. F. Xia, P. K. Lo, B. X. Mi, H. L. Tam, M. S. Wong, K. W. Cheah, C. H. Chen. “p-Doped p-Phenylenediamine-Substituted Fluorenes for Organic Electroluminescent Devices”. Organic Electronics 2009, 10, 666-673.
  • P. K. Lo, H. F. Sleiman. “Synthesis and Molecular Recognition of a Conjugated Polymer with DNA-Mimetic Properties”. Macromolecules 2008, 41, 5590-5603.
  • P. K. Lo, M. S. Wong. “Extended Calix[4]arene-Based Receptors for Molecular Recognition and Sensing”. Sensors 2008, 8, 5313-5335.
  • P. K. Lo, K. F. Li, M. S. Wong, K.W. Cheah. “Synthesis and Structure-Linear and Structure-Nonlinear Optical Properties of Multi-Dipolar Zigzag Oligoaryleneethynylenes”. J. Org. Chem. 2007, 72, 6672-6629.
  • P. K. Lo, D. Z. Chen, Q. W. Meng, M. S. Wong. “Highly Ordered Smectic Phases from Polar Calix[4]arene Derivatives”. Chem. Mater. 2006, 18, 3924-3930.
  • J. Lu, P. F. Xia, P. K. Lo, Y. Tao, M. S. Wong. “Synthesis and Properties of Multi-Triarylamine-Substituted Carbazole-Based Dendrimers with an Oligothiophene Core for Potential Applications in Organic Solar Cells and Light-Emitting Diodes”. Chem. Mater., 2006, 18, 6194-6203.
  • M. S. Wong, P. F. Xia, P. K. Lo, X. H. Sun, W. Y. Wong, S. M. Shuang. “Synthesis of Oligophenylene-Substituted Calix[4]crown-4s and Their Silver(I) Ion-Induced Nanocones Formation”. J. Org. Chem. 2006, 71, 940-946.
  • M. S. Wong, P. F. Xia, X. L. Zhang, P. K. Lo, Y, -K, Cheng, K. -K. Yeung, X. Guo, S. M. Shuang. “Facile Synthesis of Oligophenylene-Substituted Calix[4]arenes and Their Enhanced Binging Properties”. J. Org. Chem, 2005, 70, 2816-2819.

Book Chapters

  • K. Carneiro, P. K. Lo, H. F. Sleiman. “Self-Assembly of Nucleic Acids”. Supramolecular Chemistry: From Molecules to Nanomaterials, Wiley and Sons, 2011, Vol 8, 1163-2274.
  • H. Yan, P. K. Lo, C. K. McLaughlin, G. Hamblin, F. A. Aldaye, H. F. Sleiman.Self-Assembly of Metal-DNA Triangles and DNA Nanotubes with Synthetic Junctions”. Methods in Molecular Biology, Taylor & Francis (CRC Press), 2011, Vol 749, 33-47.