Dr. H Y SUN

PhD (Singapore)

Associate Professor of Department of Chemistry
Core Member of Centre of Super-Diamond and Advanced Films

drhys

Contact Information

Office: YEUNG-B6716
Phone: +852 3442-9537
Fax: +852 3442-0522
Email: hongysun@cityu.edu.hk
ORCID ID: 0000-0003-0932-6405
Scopus
Author ID:
55729273500

Research Interests

  • Bioorganic chemistry
  • Medicinal chemistry
  • Microarray
  • Cell-based assay
  • Drug action mechanism
  • Biosensor
  • Biomaterial

Dr. Sun received her B.Sc from Wuhan University and Ph.D from the National University of Singapore. Her Ph.D research focuses on systematic enzyme profiling using microarray strategy under the supervision of Professor Shao Qin Yao. She was granted a fellowship from Humboldt Foundation and carried out postdoc research with Professor Herbert Waldmann at Max Planck Institute of Molecular Physiology. Her postdoc studies involve site-specific protein modification and target identification of natural products. She joined the City University of Hong Kong in July 2011. Her current research topics include

  1. Developing microarray-based screening platform.

    To identify biologically active peptides using high-throughput screening technology.

  1. Developing novel fluorescent probes for live cell imaging studies.

    To design and synthesize fluorescent probes for bioimaging of various biomolecules.

  1. Developing novel biomaterials for biological application.

    To design and synthesize peptide-based biomaterials for controlled drug delivery and tissue engineering.

Selected Publications: (*corresponding author)

(For full publication list, please visit: http://scholar.google.com.hk/citations?user=OS_INMIAAAAJ&hl=zh-TW)

  • Xie, Y.; Ge, J.; Lei, H.; Peng, B.; Zhang, H.; Wang, D.; Pan, S.; Chen, G.; Chen, L.; Wang, Y.; Hao, Q.; Yao, S. Q.; Sun, H.* Fluorescent Probes for Single-Step Detection and Proteomic Profiling of HDACs. J. Am. Chem. Soc., 2016, 138, 15596-15604.
  • Zhang, H.; Liu, R.; Liu, J.; Li, L.; Wang, P.; Yao, S. Q.; Xu, Z.*; Sun, H.*  A Minimalist Fluorescent Probe for Differentiating Cys, Hcy and GSH in Live Cells. Chem. Sci. 2016, 7, 256-260.
  • Chen, G.; Xie, Y.; Peltier, R.; Lei, H.; Wang, P.; Chen, J.; Hu, Y.*; Wang, F.; Yao, X.; Sun, H.* Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery. ACS Appl Mater Interfaces. 2016, 8, 11204-11209.
  • Peltiter, R.; Chen, G.; Lei, H.; Zhang, M.; Gao, L.; Wang, Z.; Sun, H.* Rational Design of Peptide-based Hydrogel Resonsive to H2S. Chem. Commun. 2015, 51, 17273-17276.
  • Zhang, H.; Zhang, C.; Liu, R.; Yi, L*.; Sun, H.* A highly selective and sensitive fluorescent thiol probe through dual-reactive and dual-quenching groups. Chem. Commun. 2015, 51, 2029-2032. (Back Cover)
  • Zhang, H.; Liu, R.; Tan, Y.; Xie, W. H.; Lei, H.; Cheung, H. Y.; Sun, H.* A FRET-based Ratiometric Fluorescent Probe for Nitroxyl Detection in Living Cells. ACS Appl Mater Interfaces. 2015, 11, 5438-5443.
  • Wang, P.; Na, Z.; Fu, J; Tan, C. Y. J.; Zhang, H.; Yao S. Q.; Sun, H.* Microarray immobilization of biomolecules using a fast trans-cyclooctene (TCO)-tetrazine reaction. Chem. Commun. 2014, 50, 11818-11821. (Back Inside Cover)
  • Wang, P.; Zhang, C. J.; Chen, G. C.; Na, Z.; Yao S. Q.; Sun, H.* Site-specific immobilization of biomolecules by a biocompatible reaction between terminal cysteine and 2-cyanobenzothiazole. Chem. Commun., 2013, 49, 8644-8646.
  • Sun, H.;* Chen, G. Y. J.; Yao S. Q.* Recent advances in microarray technologies for proteomics. Chemistry & Biology, 2013, 20, 685-699.
  • Zhang, H.; Wang, P.; Yang, Y.; Sun, H.* A selective fluorescent probe for thiols based on α,β-unsaturated acyl sulfonamide. Chem. Commun., 2012, 48, 10672-10674.
  • Yi, L.;† Sun, H.;† Itzen, A.; Triola, G.; Waldmann, H.; Goody, R. S.; Wu, Y. W. Dual Labeling of Rab Proteins for Studying Protein-Protein Interactions. Angew. Chem. Intl. Ed., 2011, 50, 8287. (†, equal contribution)
  • Yi, L.;† Sun, H.;†Wu, Y. W.; Triola, G.; Waldmann, H.; Goody, R. S. A Highly Efficient Strategy for Protein C-Terminal Modification. Angew. Chem. Intl. Ed., 2010, 49, 9417-9421. (†, equal contribution) (Hot Paper)
  • Sun, H.; Lu, C. H. S.; Uttamchandani, M.; Xia, Y.; Liou, Y.-C.; Yao, S. Q. Peptide Microarray for High-throughput Determination of Phosphatase Specificity and Biology. Angew. Chem. Intl. Ed., 2008, 47, 1698-1702.
  • Lu, C. H. S.; Sun, H.; Bakar, F. B. A.; Uttamchandani, M.; Zhou, W.; Liou, Y.-C.; Yao, S. Q. Deciphering the Substrate Preferences of 14-3-3 Isoforms Using Peptide Microarray, Angew. Chem. Intl. Ed., 2008, 47, 7438-7441.
  • Sun, H.; Lu, C. H. S.; Shi, H.; Gao, L.; Yao, S. Q. Peptide Microarrays for High-throughput Studies of Ser/Thr Phosphatases, Nat. Protocols, 2008, 3, 1485-1493.

Patents

  • Christmann, M; Waldmann, H.; Willot, M.; Radtke, L.; Zeigler, S.; Sun, H.; Synthetic Inhibitors for the treatment of kidney cancers. EP10075763.2.