Prof. Michael M. Yang (楊夢甦教授)

PhD (Toronto), MACS

Head and Yeung Kin Man Chair Professor of Biomedical Sciences

Prof. Michael M. Yang

Contact Information

Office: 1A-107, 1/F, Block 1,
To Yuen Building
Phone: +852 3442-7797
Fax: +852 3442-0549
Web: Personal Homepage

Research Interests

  • Cancer Biology
  • Microfluidic Technology
  • Nanomedicine

Prof. Yang obtained his PhD from University of Toronto, Canada and received postdoctoral training in the Scripps Research Institute in USA. He is currently the Head of Department of Biomedical Sciences, and Yeung Kin-Man Chair Professor of Biomedical Sciences in City University of Hong Kong. The research interest of Yang’s group focuses development of biochip technology and nanotechnology for molecular diagnostics and therapeutic applications. Prof. Yang has published over 280 peer-reviewed scientific papers and received 23 USA/China patents. He has delivered more than 80 invited lectures in international conferences and universities, and trained 28 PhD and MPhil graduates and numerous postdoctoral fellows in his laboratory. He holds honorary professorships in Zhejiang University, the Third Military Medical University, and the PLA Graduate School of Medicine, China. Prof. Yang is a member of the Grant Review Boards of Hong Kong Healthcare and Medical Research Fund and Innovation and Technology Fund. He also served as the Technical Advisor for the Nanotechnology and Advanced Material Institute (NAMI) of Hong Kong. He has been awarded the Chunhui Scholar Award by the Ministry of Education in China in 2003, the K. C. Wong Foundation Award in 2004, the Shenzhen Science and Technology Innovation Award in 2006, the Hong Kong Technological Achievement Grand Award in 2007, the Natural Science Award by the Ministry of Education in 2015, and the Wuxi AppTech Life Science and Chemistry Award in 2016.

Representative Publications

Microfluidics for Cell Analysis

  • Li, Y. P.; Xu, T.; Zou, H.; Chen, X. M.; Sun, D.; Yang, M. S. “Cell migration microfluidics for electrotaxis-based heterogeneity study of lung cancer cells”, Biosensors and Bioelectronics, 2017, 89, 837-845.
  • Huang, X. W.; Yue, W. Q.; Liu, D. D.; Yue, J. B.; Li, J. Q.; Sun, D; Yang, M. S.; Wang, Z. K. “Monitoring the intracellular calcium response to a dynamic hypertonic environment”, Scientific Reports, 2016, 6, 23591 (8pp).
  • Zou, H.; Yue, W. Q.; Yu, W.-K.; Liu, D. D.; Fong, C. C.; Zhao, J. L. Yang, M. S. “Microfluidic platform for studying chemotaxis of adhesive cells revealed a gradient-dependent migration and acceleration of cancer stem cells”, Analytical Chemistry, 2015, 87(14), 7098-7108.
  • Li, C. W.; Yu G. D.; Jiang J. Y.; Lee, S. M. Y.; Yue, W. Q.; Yang, M. S. “A microfluidic linear node array for the study of protein-ligand interaction”, Lab Chip, 2014, 14, 3993-3999.
  • Yue, W. Q.; Zou, H.; Jin, Q. H.; Li, C. W.; Xu, T.; Fu, H. Y.; Tzang, L C. H.; Sun, H. Y.; Zhao, J. L.; Yang, M. S.. “Single layer linear array of microbeads for multiplexed analysis of DNA and proteins”, Biosensors and Bioelectronics, 2014, 54, 297-305.
  • Xu, T.; Yue, W. Q.; Li, C. W.; Yao, X. S.; Yang, M. S. “Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells”, Lab on a Chip, 2013, 13, 1060-1069.
  • Yue, W. Q.; Li, C. W.; Xu, T.; Yang, M. S. “Integrated sieving microstructures on microchannels for biological cell trapping and droplet formation”, Lab on a Chip, 2011, 11, 3352-3355.
  • Xu, T.; Li, C. W.; Yao, X. S.; Cai, G. P.; Yang, M. S. “Real-time monitoring of cell-cell communications evoked by mechanical stimulation of suspension cells using an integrated microfluidics chip”, Lab on a Chip, 2010, 10, 2271-2278.
  • Xu, T.; Li, C. W.; Yao, X. S.; Cai, G. P.; Yang, M. S. “Microfluidic formation of single cell array for parallel analysis of CRAC channel activation and inhibition”, Analytical Biochemistry, 2010, 396, 173-179.
  • Zhang, H.; Xu, T.; Li, C. W.; Yang, M. S. “A microfluidic device with microbead array for sensitive virus DNA detection and genotyping using quantum dots as fluorescence labels”, Biosensors & Bioelectronics, 2010, 25, 2402-2407.
  • Li, C. W.; Yang, M. S. “3-D streamline steering by nodes arrayed in an entangled microfluidic network”, Lab on a Chip, 2007, 7, 1712-1716.
  • Li, C. W.; Chen, R. S. Yang, M. S. “Generation of linear and non-linear concentration gradients along microfluidic channel by microtunnel controlled stepwise addition of sample solution”, Lab on a Chip, 2007, 7, 1371-1373.
  • Li, C. W.; Yang, M. S. “Dose-dependent cell-based assays in V-shaped microfluidic channels”, Lab on a Chip, 2006, 6, 921-929.
  • Yi; C.; Li, C. W.; Yang, M. S. “Microfluidics technology for manipulation and analysis of biological cells”, Analytica Chimica Acta, 2006, 560, 1-23.
  • Yang, J.; Li, C. W.; Yang, M. S. “Hydrodynamic simulation of cell docking in microfluidic channels with different dam structures”, Lab on a Chip, 2004, 4, 53–59.
  • Yang, M. S.; Li, C. W.; Yang, J. “Cell docking and on-chip monitoring of cellular reactions under controlled concentration gradient on a microfluidic device”, Analytical Chemistry, 2002, 74, 3991-4001.
  • Yang, M. S.; Yang, J.; Li, C. W.; Zhao, J. “Generation of concentration gradient by diffusive mixing and consecutive dilution in a microfluidic chip”, Lab on a Chip, 2002, 2, 158-163.

Nanotechnology and Nanomedicine

  • Li, H. L.; Liu, P.; Kaur, G.; Yao, X.; Yang, M. S. “Transparent and gas-permeable liquid marbles for culturing and drug sensitivity test of tumor spheroids”, Advanced Healthcare Materials, 2017, 1700185.
  • Zhu, S. Y.; Li, H. L; Yang, M. S.; Pang, S. W. “High sensitivity plasmonic biosensor based on nanoimprinted quasi 3D nanosquares for cell detection”, Nanotechnology, 2016, 27, 295101 (12pp).
  • Hu, L. S.; Fong, C. C.; Zhang, X. M.; Chan, L. L.; Lam,  P. K. S.; Chu, P. K.; Wong, K. Y.; Yang, M. S. “Au nanoparticles decorated TiO2 nanotube arrays as a recyclable sensor for photoenhanced electrochemical detection of bisphenol A”, Environmental Science and Technology, 2016, 50(8), 4430-4438.
  • Shi, Y. P.; Pan, Y.; Zhang, H.; Zhang, Z. M.; Li, M. J.; Yi, C. Q.; Yang, M. S. “A dual-mode nanosensor based on carbon quantum dots and gold nanoparticles for discriminative detection of glutathione in human plasma”, Biosensors and Bioelectronics, 2014, 56, 39-45. June 15
  • Liu, D. D.; Yi, C. Q.; Fong, C. C.; Jin, Q. H.; Wang, K. Q.; Wong, M. S.; Sun, D.; Zhao, J. L.; Yang, M. S. “Activation of multiple signaling pathways during the differentiation of mesenchymal stem cells cultured in silicon nanowire microenvironment”, Nanomedicine: Nanotechnology, Biology, and Medicine, 2014, 10(6), 1153-63.
  • Hu, C.; Yue, W. Q.; Yang, M. S. “Nanoparticle-based signal generation and amplification in microfluidic devices for bioanalysis”, Analyst, 2013, 138, 6709-6720.
  • Liu, D. D.; Yi, C. Q.; Fong, C. C.; Wang, K. Q.; Yu, W. K.; Wang, Z. K.; Lo, P. K.; Sun, D.; Yang, M. S. “Reorganization of cytoskeleton and transient activation of Ca2+ channels in mesenchymal stem cells cultured on silicon nanowire arrays”, ACS Applied Materials & Interfaces, 2013, 5, 13295−13304.
  • Zhang, H.; Li, C. W.; Liu L.; Xu, T.; Yang, M. S. “Multienzyme-nanoparticles amplification for sensitive virus genotyping in microfluidic microbeads array using Au nanoparticle probes and quantum dots as labels”, Biosensors and Bioelectronics, 2011, 29, 89-96.
  • Liu, D. D.; Yi, C. Q.; Fong, C. C.; Zhang, J. C.; Yang, M. S. “Gold nanoparticles promote osteogenic differentiation of mesenchymal stem cells”, ACS Nano, 2010, 4, 6439-6448.
  • Liu, D. D.; Yi, C. Q.; Zhang, D. W.; Zhang, J. C.; Yang, M. S.. “Inhibition of proliferation and differentiation of mesenchymal stem cells by carboxylated carbon nanotubes”, ACS Nano, 2010, 4(4), pp 2185–2195.
  • Qi, S. J.; Yi, C. Q.; Ji, S. L.; Fong, C. C.; Yang, M. S.. “Cell adhesion and spreading behavior on vertically aligned silicon nanowire arrays”, ACS Applied Materials & Interfaces, 2009, 1(1), 30-34. Published: JAN 2009.
  • Yi, C. Q.; Fong, C. C.; Zhang, Q.; Lee, S. T.; Yang, M. S. “The structure and function of ribonuclease A upon interacting with carbon nanotubes”, Nanotechnology, 2008, 19(9), 095102 (5 pages).
  • Zhang, D. W.; Yi, C. Q.; Zhang, J. C.; Yang, M. S. “The effects of carbon nanotubes on the proliferation and differentiation of primary osteoblasts”, Nanotechnology, 2007, 18, pp475102 (9 pages). NOV 2007.
  • Yi, C. Q.; Fong, C. C.; Chen, W. W.; Qi, S. J.; Lee, S. T.; Yang, M. S. “Inhibition of biochemical reactions by silicon nanowires through modulating enzyme activities”, ChemoBioChem, 2007, 8, 1225-1229. JUL 2007.
  • Qi, S. J.; Yi, C. Q.; Chen, W. W.; Lee, S. T.; Yang, M. S. “Effect of silicon nanowires on HepG2 adhesion and spreading”, ChemoBioChem, 2007, 8, 1115-1118. JUL 2007.
  • Yi, C. Q.; Fong, C. C.; Chen, W. W.; Qi, S. J.; Tzang, C. H.; Lee, S. T.; Yang, M. S. “Interactions between carbon nanotubes and DNA polymerase and restriction endonucleases”, Nanotechnology, 2007, 18, 025102 (6 pages).
  • Yao, H.; Yi, C. Q.; Tzang, C. H.; Zhu, J. J.; Yang, M. S. “DNA-directed self-assembly of gold nanoparticles into binary and ternary nanostructures”, Nanotechnology, 2007, 18, 015102 (7 pages).

Cancer Cell and Stem Cell Biology

  • Yu, W. K.; Wang, Z. G.; Fong, C. C.; Liu, D. D. Yip, T. C.; Au, S. K; Zhu, G. Y.; Yang, M. S. “Chemoresistant lung cancer stem cells display high DNA repair capability to remove cisplatin-DNA damage”, British Journal of Pharmacology, 2017, 174(4), 302-313.
  • Li, Y. P.; Xu, T.; Chen, X. M.; Lin, S.; Cho, M.; Sun, D.; Yang, M. S. “Effects of direct current electric fields on lung cancer cell electrotaxis in a PMMA-based microfluidic device”, Analytical and Bioanalytical Chemistry, 2017, 409, 2163-2178.
  • Zhang, Q.; Fong, C. C.; Yu, W. K.; Chen, Y.; Wei, F.; Koon, C. M.; Lau, K. M.; Leung, P. C.; Lau, C. B. S.; Fung, K. P.; Yang, M. S. “Herbal formula Astragali Radix and Rehmanniae Radix exerted wound healing effect on human skin fibroblast cell line Hs27 via the activation of transformation growth factor (TGF-b) pathway and promoting extracellular matrix (ECM) deposition”, Phytomedicine, 2012, 20, 9-16.
  • Li, H. F.; Fong, C. C.; Chen, Y.; Cai, G. P.; Yang, M. S. “Imipramine inhibits adipogenic differentiation in both 3T3-L1 preadipocytes and mouse marrow stromal cells”, Journal of Genetics and Genomics, 2012, 39, 173-180.
  • Li, H. F.; Fong, C. C.; Chen, Y.; Cai, G. P.; Yang, M. S. “beta 2- and beta 3-, but not beta 1-adrenergic receptors are involved in osteogenesis of mouse mesenchymal stem cells via cAMP/PKA signaling”, Archives of Biochemistry and Biophysics, 2010, 496 (2), 77-83.
  • Wang, J.; Chan, J. Y. W.; Fong, C. C.; Tzang, C. H.; Fung, K. P.; Yang, M. S. “Transcriptional analysis of doxorubicin-induced cytotoxicity and resistance in human hepatocellular carcinoma cell lines”, Liver International, 2009, 1338-1347.
  • Wang, J.; Fong, C. C.; Tzang, C. H.; Xiao, P. G.; Han, R.; Yang, M. S. “Gene expression analysis of human promyelocytic leukemia HL-60 cell differentiation and cytotoxicity induced by natural and synthetic retinoids”, Life Sciences, 2009, 84(17-18), 576-583.
  • Wang, J.; Tai, L. S.; Tzang, C. H.; Fong W. F.; Guan, X. Y.; Yang, M. S. “1p31, 7q21 and 18q21 chromosomal aberrations and candidate genes in acquired vinblastine resistance of human cervical carcinoma KB cells”, Oncology Reports, 2008, 19(5), 1155-1164.
  • Zhang, Q.; Fong, C. C.; Zhang, Y.; Tzang, C. H.; Fong, W. F.; Yang, M. S. “cDNA microarray analysis of the differentially expressed genes involved in murine pre-osteoclast RAW264.7 cells proliferation stimulated by dexamethasone”, Life Sciences, 2008, 82, 135-148.
  • Ma, N. F.; Lau, S. H.; Hu, L.; Xie, D.; Wu, J.; Yang, J.; Wang, Y.; Wu, M. C.; Fung, J.; Bai, X. Y.; Tzang, C. H.; Fu, L.; Yang, M. S.; Su, Y. A.; Guan, X. Y. “COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis”, Clinical Cancer Research, 2008, 14 (16), 5061-5068. 
  • Shi, Y. F.; Fong, C. C.; Cheung, P. Y.; Zhang, Q.; Wu, R. S. S.; Yang, M. S. “Hypoxia induces the activation of human hepatic stellate cells LX-2 activation through TGF-b signaling pathway”, FEBS Letters, 2007, 581, 203-210.
  • Lau, S. H.; Sham, J. S. T.; Xie, D.; Tzang, C. H.; Tang, D.; Ma, N.; Hu, L.; Wang, Y.; Wen, J. M.; Xiao, G.; Zhang, W. M.; Lau, G. K. K.; Yang, M. S.; Guan, X. Y. “Clustin plays an important role in hepatocellular carcinoma metastasis”, Oncogene, 2006, 25, 1242-1250.
  • Zhang, Y.; Fong, C. C.; Wong, M. S.; Tzang, C. H.; Lai, W. P.; Fong, W. F.; Sui, S. F.; Yang, M. S. “Molecular mechanisms of survival and apoptosis in RAW 264.7 macrophages under oxidative stress”, Apoptosis, 2005, 10, 545-556.
  • Hu, L.; Lau, S. H.; Tzang, C. H.; Wen, J. M.; Wang, W.; Huang, M.; Wang, Y.; Wu, M. C.; Huang, J. F.; Zeng, W. F.; Sham, J. S. T.; Yang, M. S.; Guan, X. Y. “Association of overexpression of vimentin and hepatocellular carcinoma metastasis.” Oncogene, 2004, 23, 298-302.
  • Zhang, Y.; Song, S.; Fong, C. C.; Tsang, C. H.; Yang, Z.; Yang, M. S. “cDNA microarray analysis of gene expression profiles in human fibroblast cells irradiated with red light”, Journal of Investigative Dermatology, 2003, 120, 849-857.