Faculty Profile
YANG, Mengsu (Michael)

Prof. YANG, Mengsu (Michael) (楊夢甦)

Yeung Kin Man Chair Professor of Biomedical Sciences

Vice-President (Research & Technology)

Director (BTC)

PhD (Toronto)

Professor Michael Yang Mengsu is currently Vice-President (Research and Technology), Chair Professor in the Department of Biomedical Sciences, and Director of both the Tung Biomedical Sciences Centre and Shenzhen Biotechnology and Health Centre of City University of Hong Kong (CityU). He is responsible for “HK Tech 300”, the largest university-based entrepreneurship programme in Asia. He received a Bachelor’s Degree of Science from Xiamen University, China, a Doctor of Philosophy (PhD) from the University of Toronto, Canada, and postdoctoral training from The Scripps Research Institute, the United States.

Professor Yang’s research interests focus on studying cancer biology and developing biochips and nanotechnology for diagnostics and therapeutic applications. He has published over 280 peer-reviewed scientific papers, received 33 US/China patents, delivered over 150 lectures in international conferences and academic institutions, and trained over 40 PhD graduates and 30 postdoctoral fellows. He co-founded Prenetics and Cellomics, biotech companies based on technologies developed in his laboratory in CityU.

Professor Yang was listed among the top 2% of the world’s most highly cited scientists, according to metrics compiled by Stanford University in 2020 and 2021. He serves on the Hong Kong’s Research Grants Council, the Health and Medical Research Fund, and the Innovation and Technology Fund. He holds Honorary Professorships at the Institute of Microsystems of the Chinese Academy of Science, Zhejiang University, and the Army Medical University. He was awarded the ‘Chunhui Scholar Award’ by the Ministry of Education of China in 2003, the ‘K. C. Wong Foundation Award’ in 2004, the ‘Shenzhen Science and Technology Innovation Award’ in 2006, the ‘Hong Kong Technological Achievement Grand Award’ in 2007, the ‘Natural Science Award, Second-Class’ from the Ministry of Education in 2015, the ‘Wuxi AppTech Life Science and Chemistry Award’ in 2016, and a Gold Medal at the 47th International Exhibition of Inventions of Geneva in 2019.

楊夢甦教授現任香港城市大學（城大）副校長（研究及科技）、生物醫學系講座教授，以及董氏生物醫學中心及深圳生物醫藥科技中心主任。他負責的「HK Tech 300」是亞洲最大的大學創新創業計劃。他分別於廈門大學和多倫多大學獲得學士和博士學位，並在加州斯克利普斯研究所從事博士後研究。

楊教授的研究團隊致力研究腫瘤生物學，並開發生物晶片和納米技術，以應用於疾病診斷和治療。他發表了280多篇同行評審科學論文；獲得33項美國及中國專利；應邀在 150多個國際會議和學術機構發表演講。他指導了逾 40位博士畢業生及30多位博士後研究員。他亦參與創辦基於城大技術而衍生的生物科技公司Prenetics及Cellomics。

根據2020年及2021年史丹福大學的排名指標，楊教授獲評為論文被高度引用的全球排名前2%科學家。他是香港研究資助局、醫療衞生研究基金，以及創新科技基金成員，還兼任中國科學院微系統所、浙江大學及陸軍軍醫大學榮譽教授。楊教授曾獲中國教育部「春晖學者獎」（2003）、「王寬誠教育基金會學者獎」（2004）、「深圳市創新科技獎」（2006）、「香港工商業獎科技成就大獎」（2007）、教育部「自然科學二等獎」（2015）、「藥明康德生命化學研究獎」（2016），以及第47屆日內瓦國際發明展金獎（2019）。

Media Publicity

Representative Publications

Microfluidics for Cell Analysis

  • High Throughput Confined Migration Microfluidic Device for Drug Screening, Small, 2023, 2207194.
  • Dually stimulative single-chain polymeric nano lock with dynamic ligands for sensitive detection of circulating tumor cells, Biosensors and Bioelectronics, 2022, 217, 114692.
  • Single Cell Analysis of Mechanical Properties and EMT-related Gene Expression Profiles in Cancer Fingers, iScience, 2022, 25(3), 103917.
  • Microdissected ‘cuboids’ for microfluidic drug testing of intact tissues, Lab on a Chip, 2021, 21, 122-142.
  • Single cell target gene mutation analysis by arc-edge-channel monolithic valve microfluidic cell isolation and locked nucleic acid based PCR detection, Sensors and Actuators B: Chemical, 2019, 293, 224-234.
  • Recent advances in microfluidic technology for manipulation and analysis of biological cells (2007-2017), Analytica Chimica Acta, 2018, 1044, 29-65.
  • Electrotaxis of cancer stem cells is associated with both activation of stretch-activated cation channels and internal calcium release, Bioelectrochemistry, 2018, 124, 80-92.
  • Cell migration microfluidics for electrotaxis-based heterogeneity study of lung cancer cells, Biosensors and Bioelectronics, 2017, 89, 837-845.
  • Microfluidic platform for studying chemotaxis of adhesive cells revealed a gradient-dependent migration and acceleration of cancer stem cells, Analytical Chemistry, 2015, 87(14), 7098-7108.
  • A microfluidic linear node array for the study of protein-ligand interaction, Lab Chip, 2014, 14, 3993-3999.
  • Single layer linear array of microbeads for multiplexed analysis of DNA and proteins, Biosensors and Bioelectronics, 2014, 54, 297-305.
  • Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells, Lab on a Chip, 2013, 13, 1060-1069.
  • Integrated sieving microstructures on microchannels for biological cell trapping and droplet formation, Lab on a Chip, 2011, 11, 3352-3355.
  • Real-time monitoring of cell-cell communications evoked by mechanical stimulation of suspension cells using an integrated microfluidics chip, Lab on a Chip, 2010, 10, 2271-2278.
  • Microfluidic formation of single cell array for parallel analysis of CRAC channel activation and inhibition, Analytical Biochemistry, 2010, 396, 173-179.
  • A microfluidic device with microbead array for sensitive virus DNA detection and genotyping using quantum dots as fluorescence labels, Biosensors & Bioelectronics, 2010, 25, 2402-2407.
  • 3-D streamline steering by nodes arrayed in an entangled microfluidic network, Lab on a Chip, 2007, 7, 1712-1716.
  • Generation of linear and non-linear concentration gradients along microfluidic channel by microtunnel controlled stepwise addition of sample solution, Lab on a Chip, 2007, 7, 1371-1373.
  • Dose-dependent cell-based assays in V-shaped microfluidic channels, Lab on a Chip, 2006, 6, 921-929.
  • Microfluidics technology for manipulation and analysis of biological cells, Analytica Chimica Acta, 2006, 560, 1-23.
  • Hydrodynamic simulation of cell docking in microfluidic channels with different dam structures, Lab on a Chip, 2004, 4, 53–59.
  • Cell docking and on-chip monitoring of cellular reactions under controlled concentration gradient on a microfluidic device, Analytical Chemistry, 2002, 74, 3991-4001.
  • Generation of concentration gradient by diffusive mixing and consecutive dilution in a microfluidic chip, Lab on a Chip, 2002, 2, 158-163.

Cancer Biology & Nanomedicine

  • Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network, Molecular Cancer, 2023, 22, 21.
  • Three-dimensional Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor-on-a-chip, Advanced Healthy Materials, 2023, 2202609.
  • Single-cell RNA-seq recognized the initiator of epithelial ovarian cancer recurrence, Oncogene, 2022, 41(6), 895-906.
  • Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance, Nanomedicine. 2021, 16, 1411–1427.
  • Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ, Oncogene, 2021, 40, 1775–1791.
  • Magnetothermal miniature reactors based on iron oxide nanocubes-coated liquid marbles, Advanced Healthcare Materials, 2021, 2001658 (8 pages).
  • Single-cell EMT-related transcriptional analysis uncovers the intra-cluster heterogeneity of tumor cell clusters in epithelial ovarian cancer ascites, Oncogene, 2020, 39(21), 4227–4240.
  • Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy, Theranostics, 2020, 10(3), 1181-1196.
  • Recent Progress of Ferroptosis Inducers for Cancer Therapy, Advanced Materials, 2019, 1904197, pp25.
  • Efficient RNA drug delivery using red blood cell extracellular vesicles, Nature Communications, 2018, 9(1), 2359 (15 pages).
  • Transparent and gas-permeable liquid marbles for culturing and drug sensitivity test of tumor spheroids, Advanced Healthcare Materials, 2017, 1700185.
  • Chemoresistant lung cancer stem cells display high DNA repair capability to remove cisplatin-DNA damage, British Journal of Pharmacology, 2017, 174(4), 302-313.
  • Activation of multiple signaling pathways during the differentiation of mesenchymal stem cells cultured in silicon nanowire microenvironment, Nanomedicine: Nanotechnology, Biology, and Medicine, 2014, 10(6), 1153-63.
  • Reorganization of cytoskeleton and transient activation of Ca2+ channels in mesenchymal stem cells cultured on silicon nanowire arrays, ACS Applied Materials & Interfaces, 2013, 5, 13295−13304.
  • Multienzyme-nanoparticles amplification for sensitive virus genotyping in microfluidic microbeads array using Au nanoparticle probes and quantum dots as labels, Biosensors and Bioelectronics, 2011, 29, 89-96.
  • Gold nanoparticles promote osteogenic differentiation of mesenchymal stem cells, ACS Nano, 2010, 4, 6439-6448.
  • Inhibition of proliferation and differentiation of mesenchymal stem cells by carboxylated carbon nanotubes, ACS Nano, 2010, 4(4), pp 2185–2195.
  • COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis, Clinical Cancer Research, 2008, 14 (16), 5061-5068.
  • DNA-directed self-assembly of gold nanoparticles into binary and ternary nanostructures, Nanotechnology, 2007, 18, 015102 (7 pages).
  • Hypoxia induces the activation of human hepatic stellate cells LX-2 activation through TGF-b signaling pathway, FEBS Letters, 2007, 581, 203-210.
  • Clustin plays an important role in hepatocellular carcinoma metastasis, Oncogene, 2006, 25, 1242-1250.
  • Molecular mechanisms of survival and apoptosis in RAW 264.7 macrophages under oxidative stress, Apoptosis, 2005, 10, 545-556.
  • Association of overexpression of vimentin and hepatocellular carcinoma metastasis. Oncogene, 2004, 23, 298-302.

24 May 2023

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