Faculty Profile
YIN, Huiyong

YIN, Huiyong (尹慧勇)

Professor

Associate Dean, Research (Jockey Club College of Veterinary Medicine and Life Sciences)

PhD (Vanderbilt University)

MS (Chinese Academy of Sciences)

  • 1A-209, 2/F, Block 1, To Yuen Building
  • +852 3442-2812
  • +852 3442-0549
  • CityU Scholars
  • Lab Website
  • metabolic reprogramming • metabolomics/ lipidomics • atherosclerosis • liver cancer • lipid peroxidation • hyperuricemia and gout • mass spectrometry • ALDH2 • Aldolase

Professor Huiyong YIN is currently the tenured Professor of Biomedical Sciences in Metabolism and Metabolic Diseases in the Department of Biomedical Sciences. Before joining City University of Hong Kong in February 2023, Prof. Yin was the Senior Principal Investigator (Professor Level II, 中科院特聘研究员, 二级教授) and Group Leader of Lipid Metabolism in Human Nutrition-related Diseases at Shanghai Institute of Nutrition and Health (SINH), Chinese Academy of Sciences (CAS), Shanghai, China. He was also the Distinguished Adjunct Professor in the School of Life Sciences and Technology in ShanghaiTech University since 2013. He obtained his BSc from Tongji University and MSc from Shanghai Institute of Organic Chemistry (SIOC), CAS, and PhD in Chemistry from Vanderbilt University in 2002. In 2003, Prof. Yin joined Vanderbilt University School of Medicine as a Research Instructor in the Division of Clinical Pharmacology, and was promoted to a Research Assistant Professor in 2005 and Associate Professor in 2008 in the Departments of Pharmacology, Medicine, and Chemistry. He also served as the Director for the Core Laboratory of Drug Metabolism and Pharmacokinetics (DMPK) in the drug discovery program at Vanderbilt University from 2007–2009. In August 2011, Prof. YIN was recruited back to the Institute of Nutritional Sciences (INS), Shanghai Institutes of Biological Sciences (SIBS), CAS, under the global talent recruitment program by Shanghai Municipal Government and CAS. He was the founding director of the Mass Spectrometry Facility for Nutrition and Food Safety at INS, SIBS from 2011 to 2017.

Professor Yin is one of the leading scientists in the field of redox regulation of glucose and lipid metabolism in human metabolic diseases. His research interest has been focusing on the understanding of metabolic reprogramming in carbohydrate and lipid metabolism in metabolic diseases including atherosclerosis, liver cancer, hyperuricemia and gout. For the past 20 years, Prof. Yin has made significant contributions in understanding the roles and underlying mechanisms of free radical lipid peroxidation in human diseases including atherosclerosis using the state-of-the art metabolomics/lipidomics approaches (Yin et al JACS, 2000; 2002; Yin et al Chem. Rev. 2011; Zhong et al, Redox Biol. 2015; Zhong et al, Free Radic. Biol. Med. 2019), and discovered the novel non-enzymatic functions of Aldehyde Dehydrogenase 2 (ALDH2) in cardiovascular disease (CVD) (Zhong et al, J. Clin. Invest. 2019; Li et al, JCI Insight, 2021; Zhong et al, Redox Biol. 2021; Zhang et al, Nat. Rev. Cardiol. 2023). His research for the past five years has defined the pathways in metabolic reprogramming in liver cancer mediated by a key glycolytic enzyme fructose-1,6-bisphosphate aldolase B (ALDOB) (Li et al, Nature Cancer, 2020; He et al, PLoS Biol., 2020; Liu et al, Hepatology, 2021). Using a precision medicine approach based on metabolomics and machine learning algorithms, Prof. Yin and his collaborators have established prediction models in assessing risks for gout attacks in asymptomatic hyperuricemia patients and the frequencies for gout flares (Shen et al, Arthritis. Rheumatol., 2021; Lu et al, Nat. Rev. Rheumatol., 2019). Since 2000, Prof. Yin has co-authored around 160 peer-reviewed manuscripts in SCI-indexed journals including Science, Nature, Cell Metabolism, Nature Cancer, Nature Metabolism, Nature Review Cardiology, Nature Reviews Rheumatology, Molecular Cell, Journal of American Chemical Society, Hepatology, Redox Biology, Arthritis & Rheumatology, Free Radical Biology and Medicine, Journal of Biological Chemistry, Journal of Clinical Endocrinology and Metabolism, and Journal of American Society for Mass Spectrometry with >11,400 Google Scholar citations and h-index of 58 (as of February 2023).  Prof. Yin has been listed as the top 2% of the Most-Cited Scientists by Stanford University since 2021 and was awarded prestigious “Senior International Scientists” in 2021 by National Natural Science Fund of China.

Professor Yin received “Pollyanna Chu Yuet Wah Outstanding Mentor Award” of Chinese Academy of Sciences (中国科学院朱李月华优秀教师奖) in 2022; “Senior International Scientist” (外国资深研究学者) by NSF-China in 2021; “Outstanding Mentor Award” from ShanghaiTech University in 2020; CAS BR (2011) and “Shanghai Expert” (上海特聘专家) by Shanghai Municipal Government in 2012; Travel Award from Society for Free Radical Biology and Medicine (SFRBM) in 2004 and Young Investigator Award in 2005; Best Research Paper from Vanderbilt School of Medicine 2006; Warren Fellowship from Department of Chemistry at Vanderbilt University in 2000; CAS President Award for outstanding graduate student in 1995.

Research Interests

  • Redox regulation of lipid and carbohydrate metabolism: lipid peroxidation, Reactive Oxygen Species (ROS), and ferroptosis
  • Metabolic homeostasis and tissue cross-talks
  • Metabolic reprogramming in tissue microenvironment
  • Immunometabolism in atherosclerosis and myocardial infarction
  • Metabolic interplays of cancer cells and immune cells
  • Nutrient sensing and metabolic pathways in metabolic diseases
  • Disease biomarker discovery using multi-omics integration, including metabolomics/lipidomomics, proteomics, transcriptomics, and single cell analysis, in combination with machine learning algorithms

Research Profiles

ORCID

https://orcid.org/0000-0001-7049-1560

Loop (Frontiers)

https://loop.frontiersin.org/people/44466/

Google Scholar

https://scholar.google.com/citations?user=p032JwkAAAAJ

Scopus ID: 7403113776

https://www.scopus.com/authid/detail.uri?authorId=7403113776

Researchgate

https://www.researchgate.net/profile/Huiyong-Yin-2

Recent External Competitive Grants (Since 2012)

  • Natural Science Foundation of China (NSFC), Categorized Key Projects (2023–2025, 中国自然科学基金委专项), ”Fructose uptake and metabolic homeostasis”, 2,500,000 RMB, No. 32241017, PI
  • Natural Science Foundation of China (NSFC), Research Fund for Senior International Scientists (2022–2023, 中国自然科学基金委外国资深研究学者), ”Physiological and pathophysiological basis for enzymatic plasticity”, 1,600,000 RMB, No. 32150710522, PI
  • Natural Science Foundation of China (NSFC), Key Research Project (2021–2025, 中国自然科学基金委重点项目), ”Mitochondrial ALDH2 in cholesterol metabolism”, 3,450,000 RMB, No. 32030053, PI
  • Ministry of Science and Technology of China (MOST), Key Research Project (2022–2025), ”Early detection, phenotyping and precision treatment of inflammatory arthritis”, 1,050,000 RMB, No. 2022YFC2503300, Co-I (Group Member)
  • Ministry of Science and Technology of China (MOST), Key Research Project (2019–2024), ”Detection and functional studies of novel metabolites during major organ development”, 860,000 RMB, No. 2022YFC2503300, Co-I
  • Shanghai Municipal Science and Technology Commission, Animal Model Project (2022–2025), ”Diabetic mouse model based on beta cell-specific ALDOB KO and R46A mutant”, 250,000 RMB, No. 22140903300, PI
  • Natural Science Foundation of China (NSFC), Major Research Program on Spatiotemporal Regulation of Metabolism (2019–2021), ”Spatiotemporal control of lipid metabolism by ALDH2 in Atherosclerosis”, 850,000 RMB, No. 91857112, PI
  • Ministry of Science and Technology of China (MOST), Key Research Project (2016–2020), ”Quality control and composition analysis during food processing”, 1,500,000 RMB, No. 2016YFD0400205, Co-I
  • Natural Science Foundation of China (NSFC), General Research Project (2017–2020), ”Fructose-1,6-bisphosphate aldolase in metabolic reprogramming of hepatocellular carcinoma”, 610,000 RMB, No. 31671231, PI
  • Natural Science Foundation of China (NSFC), General Research Project (2015–2018), ”Characterisation and functional study of a novel oxidized phospholipids in LDL in atherosclerosis”, 850,000 RMB, No. 31470831, PI
  • Ministry of Science and Technology of China (MOST), China Precision Medicine Initiative (2016–2018), ”Precision medicine approach to study gout using proteomics and metabolomics”, 1,000,000 RMB, No. 2016YFC0903403, Co-PI
  • Ministry of Science and Technology of China (MOST), Key Research Project (2012–2016), ”Biomarkers in non-alcoholic fatty liver disease”, 1,280,000 RMB, No. 2012CB524905, Co-I
  • Natural Science Foundation of China (NSFC), Major Research Program on Vascular homeostasis and remodelling (2015–2017), ”Tipping point and regulatory networks during the progression of atherosclerosis”, 750,000 RMB, No. 91439103, Co-PI
  • Natural Science Foundation of China (NSFC), General Research Project (2012–2015), ”Mitochondrial cardiolipin oxidation in apoptosis”, 600,000 RMB, No. 31170809, PI

Academic Profiles

  • Secretary General, Asian Pacific Gout Consortium (APGC), (2018–)
  • Managing Committee Member, HNE Club associated with the Society for Free Radical Research International (SFRRI) (2010–)
  • Vice president and Secretary General, Chinese Society for Free Radical Biology and Medicine, Biophysical Society of China (2020–)
  • Deputy Secretary General and Council Member, Chinese Society for Metabolomics, Biophysical Society of China (2019–)
  • Secretary General, Chinese Society for Hyperuricemia and Gout, China Society of Geriatrics (2018–)
  • Council Member, Chinese Society for Metabolic Biology, Biophysical Society of China (2019–)
  • Council member of Sub-committee of Atherosclerosis, Chinese Association of Pathophysiology (2016–)
  • Council member of China Society of Geriatrics (2018–)

Editorial Responsibilities

Editor

Free Radical Biology and Medicine

Editorial Board member

Redox Biology

Redox Biochemistry and Chemistry

Redox Experimental Medicine

Global translational Medicine

Gout, Urate, and Crystal Deposition Disease

Journal of Integrative Agriculture

Position Availability

We are looking for motivated people to join our team as PhD students, postdoctoral fellows or research assistants. Please send you CV and a short summary of your previous research experience to Prof. YIN Huiyong at huiyoyin@cityu.edu.hk.

Selected Publication List (Since 2017)

(* corresponding author)

2023

  • Hao S, Zhang S, Ye J, Chen L, Wang Y, Pei S, Zhu Q, Xu J, Tao Y, Zhou N, Yin H, Duan CW, Mao C, Zheng M, Xiao Y. Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis. EMBO Rep. 2023 Mar 2:e56932. doi: 10.15252/embr. 202356932. Online ahead of print. PMID: 3686232
  • Zhang J, Guo Y, Zhao X, Pang J, Pan C, Wang J, Wei S, Yu X, Zhang C, Chen Y*, Yin H*, Xu F*. The role of aldehyde dehydrogenase 2 in cardiovascular disease. Nat Rev Cardiol. 2023 Feb 13. doi: 10.1038/s41569-023-00839-5. Online ahead of print. PMID: 36781974

2022

  • Zhao S, Tian Y, Wang S, Yang F, Xu J, Qin Z, Liu X, Cao M, Zhao P, Zhang G, Wang Z, Zhang Y, Wang Y, Lin K, Fang S, Wang Z, Han T, Tian M, Yin H, Tian J, Yu B. Prognostic value of gut microbiota-derived metabolites in patients with ST-segment elevation myocardial infarction. Am J Clin Nutr. 2022 Dec 28: S0002-9165(22)10614-3. doi: 10.1016/j.ajcnut.2022.12.013. Online ahead of print. PMID: 36811471
  • Shao F, Li R, Guo Q, Qin R, Su W, Yin H*, Tian L*. Plasma Metabolomics Reveals Systemic Metabolic Alterations of Subclinical and Clinical Hypothyroidism. J Clin Endocrinol Metab. 2022 Dec 17; 108(1):13-25. doi: 10.1210/clinem/dgac555.
  • Ding Y, Jiang Y, Zhu M, Zhu Q, He Y, Lu Y, Wang Y, Qi J, Feng Y, Huang R, Yin H, Li S and Sun Y. Follicular fluid lipidomic profiling reveals potential biomarkers of polycystic ovary syndrome: A pilot study. Front. Endocrinol. 2022, 13:960274. doi: 10.3389/fendo.2022.960274
  • Murphy MP, Bayir H, Belousov V, Chang CJ, Davies KJA, Davies MJ, Dick TP, Finkel T, Forman HJ, Janssen-Heininger Y, Gems D, Kagan VE, Kalyanaraman B, Larsson NG, Milne GL, Nyström T, Poulsen HE, Radi R, Van Remmen H, Schumacker PT, Thornalley PJ, Toyokuni S, Winterbourn CC, Yin H, Halliwell B. Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo. Nat Metab. 2022 Jun; 4(6):651-662. doi: 10.1038/s42255-022-00591-z. Epub 2022 Jun 27. PMID: 35760871
  • Cao K, Liu Y, Liang N, Shen X, Li R, Yin H*, Xiang L*. Fatty Acid Profiling in Facial Sebum and Erythrocytes From Adult Patients With Moderate Acne. Front Physiol. 2022 Jun 21; 13:921866. doi: 10.3389/fphys.2022.921866. eCollection 2022.PMID: 35800343
  • Li L, Zhong S, Li R, Liang N, Zhang L, Xia S, Xu X, Chen X, Chen S, Tao Y, Yin H.* Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression. JCI Insight. 2022 Apr 8; 7(7): e155869. doi: 10.1172/jci.insight.155869.PMID: 35393951
  • Lu J, He Y, Terkeltaub R, Sun M, Ran Z, Xu X, Wang C, Li X, Hu S, Xue X, Yan F, Zhang H, Yin H, Shi Y, Dalbeth N, Li C. Colchicine prophylaxis is associated with fewer gout flares after COVID-19 vaccination. Ann Rheum Dis. 2022 Aug; 81(8):1189-1193. doi: 10.1136/annrheumdis-2022-222199. Epub 2022 Mar 11. PMID: 35277390
  • Sun L, Du H, Zong G, Guo Y, Chen Y, Chen Y, Yin H, Pei P, Yang L, Chu Q, Yu C, Li Y, Lv J, Zheng H, Zhou P, Chen J, Li L, Chen Z, Lin X; China Kadoorie Biobank Collaborative Group. Associations of erythrocyte polyunsaturated fatty acids with incidence of stroke and stroke types in adult Chinese: a prospective study of over 8000 individuals. Eur J Nutr. 2022 Sep; 61(6):3235-3246. doi: 10.1007/s00394-022-02879-y. Epub 2022 Apr 21. PMID: 35445833
  • Xiong Q, Sun L, Luo Y, Yun H, Shen X, Yin H, Chen X, Lin X. Different Isocaloric Meals and Adiposity Modify Energy Expenditure and Clinical and Metabolomic Biomarkers During Resting and Exercise States in a Randomized Crossover Acute Trial of Normal-Weight and Overweight/Obese Men. J Nutr. 2022 Apr 1; 152(4):1118-1129. doi: 10.1093/jn/nxac006.PMID: 35020917

2021

  • Liu G, Wang N, Zhang C, Li M, He X, Yin C, Tu Q, Shen X, Zhang L, Lv J, Wang Y, Jiang H, Chen S, Li N, Tao Y*, Yin H*. Fructose-1,6-Bisphosphate Aldolase B Depletion Promotes Hepatocellular Carcinogenesis Through Activating Insulin Receptor Signaling and Lipogenesis. Hepatology. 2021 Dec; 74(6):3037-3055. doi: 10.1002/hep.32064. Epub 2021 Aug 26. PMID: 34292642
  • Huo S, Sun L, Zong G, Shen X, Zheng H, Jin Q, Li H, Yin H, Lin X. Changes in Plasma Metabolome Profiles Following Oral Glucose Challenge among Adult Chinese. Nutrients. 2021 Apr 27; 13(5):1474. doi: 10.3390/nu13051474.PMID: 33925473
  • Pan Q#, Zhong S#, Wang H, Wang X, Li N, Li Y, Zhang G, Yuan H, Lian Y, Chen Q, Han Y, Guo J, Liu Q, Qiu T, Jiang J, Li Q, Tan M, Yin H, Peng J, Xiao Y, Qin J. The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability. Mol Cell. 2021 Jul 1; 81(13):2736-2751.e8. doi: 10.1016/j.molcel.2021.04.009. Epub 2021 Apr 30. PMID: 33932349
  • Li X, Liu T, Wu TT, Feng Y, Peng SJ, Yin H*, Wu YC*. SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson's Disease. Front Neurol. 2021 Apr 15; 12: 652882. doi: 10.3389/fneur.2021.652882. eCollection 2021.PMID: 33935952
  • Shen X#, Wang C#, Liang N, Liu Z, Li X, Zhu ZJ, Merriman TR, Dalbeth N, Terkeltaub R, Li C*, Yin H*. Serum Metabolomics Identifies Dysregulated Pathways and Potential Metabolic Biomarkers for Hyperuricemia and Gout. Arthritis Rheumatol. 2021 Sep; 73(9):1738-1748. doi: 10.1002/art.41733. Epub 2021 Aug 6. PMID: 33760368 (# Equal contribution)
  • Zhong S#, Li L#, Liang N, Zhang L, Xu X, Chen S, Yin H*. Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver. Redox Biol. 2021 May; 41:101919. doi: 10.1016/j.redox.2021.101919. Epub 2021 Mar 10. PMID: 33740503 (# Equal contribution)
  • Chen X, Li X, Xu X, Li L, Liang N, Zhang L, Lv J, Wu YC, Yin H*. Ferroptosis and cardiovascular disease: role of free radical-induced lipid peroxidation. Free Radic Res. 2021 Apr; 55(4):405-415. doi: 10.1080/10715762.2021.1876856. Epub 2021 Jan 27. PMID: 33455488
  • Jiang Y#, Tao Y#, Zhang X#, Wei X, Li M, He X, Zhou B, Guo W, Yin H*, Cheng S.* Loss of STAT5A promotes glucose metabolism and tumor growth through miRNA-23a-AKT signaling in hepatocellular carcinoma. Mol Oncol. 2021 Feb; 15(2):710-724. doi: 10.1002/1878-0261.12846. Epub 2020 Nov 22. PMID: 33155364

2020

  • He X#, Li M#, Yu H, Liu G, Wang N, Yin C, Tu Q, Narla G, Tao Y*, Cheng S*, Yin H.* Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex. PLoS Biol. 2020 Dec 4; 18(12): e3000803. doi: 10.1371/journal.pbio.3000803. eCollection 2020 Dec. PMID: 33275593
  • Zhang M, Gao J, Zhao X, Zhao M, Ma D, Zhang X, Tian D, Pan B, Yan X, Wu J, Meng X, Yin H, Zheng L. p38α in macrophages aggravates arterial endothelium injury by releasing IL-6 through phosphorylating megakaryocytic leukemia 1. Redox Biol. 2021 Jan; 38:101775. doi: 10.1016/j.redox.2020.101775. Epub 2020 Nov 1. PMID: 33171330
  • Li Q, Liu G, Wang N, Yin H and Li Z. Synthesis and anticancer activity of benzotriazole derivatives. Journal of Heterocyclic Chemistry. 2020; 57:1220-1227.
  • Lu J, He Y, Cui L, Xing X, Liu Z, Li X, Zhang H, Li H, Sun W, Ji A, Wang Y, Yin H, Li C. Hyperuricemia Predisposes to the Onset of Diabetes via Promoting Pancreatic β-Cell Death in Uricase-Deficient Male Mice. Diabetes. 2020 Jun; 69(6): 1149-1163. doi: 10.2337/db19-0704. Epub 2020 Apr 20. PMID: 32312870
  • Liu G#, Shi A#, Wang N, Li M, He X, Yin C, Tu Q, Shen X, Tao Y*, Wang Q*, Yin H. *Polyphenolic Proanthocyanidin-B2 suppresses proliferation of liver cancer cells and hepatocellular carcinogenesis through directly binding and inhibiting AKT activity. Redox Biol. 2020 Oct; 37:101701. doi: 10.1016/j.redox.2020.101701. Epub 2020 Aug 25. PMID: 32863234
  • Li M#, He X#, Guo W#, Yu H, Zhang S, Wang N, Liu G, Sa R, Shen X, Jiang Y, Tang Y, Zhuo Y, Yin C, Tu Q, Li N, Nie X, Li Y, Hu Z, Zhu H, Ding J, Li Z, Liu T, Zhang F, Zhou H, Li S, Yue J, Yan Z, Cheng S*, Tao Y*, Yin H.* Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways. Nat Cancer. 2020 Jul; 1(7):735-747. doi: 10.1038/s43018-020-0086-7. Epub 2020 Jul 6. PMID: 35122041
  • Wang N#, Liu H#, Liu G, Li M, He X, Yin C, Tu Q, Shen X, Bai W, Wang Q*, Tao Y*, Yin H.* Yeast β-D-glucan exerts antitumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis. Redox Biol. 2020 May; 32:101495. doi: 10.1016/j.redox.2020.101495. Epub 2020 Mar 7. PMID: 32171725
  • Xu L, Hu C, Liu Y, Li S, Vetter W, Yin H*, Wang Y*. Development of a sensitive and quantitative method for the identification of two major furan fatty acids in human plasma. J Lipid Res. 2020 Apr; 61(4):560-569. doi: 10.1194/jlr.D119000514. Epub 2020 Feb 6. PMID: 32029512
  • Jiang Y, Qi J, Xue X, Huang R, Zheng J, Liu W, Yin H, Li S. Ceramide subclasses identified as novel lipid biomarker elevated in women with polycystic ovary syndrome: a pilot study employing shotgun lipidomics. Gynecol Endocrinol. 2020 Jun; 36 (6): 508-512. doi: 10.1080/09513590.2019.1698026. Epub 2019 Dec 3. PMID: 3179336
  • Li S, Qi J, Tao Y, Zhu Q, Huang R, Liao Y, Yue J, Liu W, Zhao H, Yin H*, Sun Y*. Elevated levels of arachidonic acid metabolites in follicular fluid of PCOS patients. Reproduction. 2020 Feb; 159(2):159-169. doi: 10.1530/REP-19-0136. PMID: 3177010

2019

  • Shi L, Chen X, Zang A, Li T, Hu Y, Ma S, Lü M, Yin H, Wang H, Zhang X, Zhang B, Leng Q, Yang J, Xiao H. TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis. PLoS Biol. 2019 Aug 21; 17(8):e3000420. doi: 10.1371/journal.pbio.3000420. eCollection 2019 Aug. PMID: 31433805
  • Lu J, Dalbeth N, Yin H, Li C, Merriman TR, Wei WH. Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul; 15(7): 413-426. doi: 10.1038/s41584-019-0222-x.PMID: 31118497
  • Ceddia RP, Downey JD, Morrison RD, Kraemer MP, Davis SE, Wu J, Lindsley CW, Yin H, Daniels JS, Breyer RM. The effect of the EP3 antagonist DG-041 on male mice with diet-induced obesity. Prostaglandins Other Lipid Mediat. 2019 Oct; 144:106353. doi: 10.1016/j.prostaglandins.2019.106353. Epub 2019 Jul 2. PMID: 31276827
  • Feng Z, Wei Y, Zhang Y, Qiu Y, Liu X, Su L, Liang N, Yin H, Ding Q. Identification of a rhodanine derivative BML-260 as a potent stimulator of UCP1 expression. Theranostics. 2019 May 26; 9(12): 3501-3514. doi: 10.7150/thno.31951. eCollection 2019.PMID: 31281493
  • Xue JH, Chen GD, Hao F, Chen H, Fang Z, Chen FF, Pang B, Yang QL, Wei X, Fan QQ, Xin C, Zhao J, Deng X, Wang BA, Zhang XJ, Chu Y, Tang H, Yin H, Ma W, Chen L, Ding J, Weinhold E, Kohli RM, Liu W, Zhu ZJ, Huang K, Tang H, Xu GL. A vitamin-C-derived DNA modification catalysed by an algal TET homologue. Nature. 2019 May; 569(7757): 581-585. doi: 10.1038/s41586-019-1160-0. Epub 2019 May 1. PMID: 31043749
  • Zhong S, Li L, Shen X, Li Q, Xu W, Wang X, Tao Y, Yin H.* An update on lipid oxidation and inflammation in cardiovascular diseases. Free Radic Biol Med. 2019 Nov 20; 144:266-278. doi: 10.1016/j.freeradbiomed.2019.03.036. Epub 2019 Apr 1. PMID: 30946962
  • Li L, Zhong S, Shen X, Li Q, Xu W, Tao Y, Yin H.* Recent development on liquid chromatography-mass spectrometry analysis of oxidized lipids. Free Radic Biol Med. 2019 Nov 20; 144:16-34. doi: 10.1016/j.freeradbiomed.2019.06.006. Epub 2019 Jun 13. PMID: 31202785
  • Chao H, Lin C, Zuo Q, Liu Y, Xiao M, Xu X, Li Z, Bao Z, Chen H, You Y, Kochanek PM, Yin H, Liu N, Kagan VE, Bayır H, Ji J. Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury. J Neurosci. 2019 Mar 6; 39(10):1930-1943. doi: 10.1523/JNEUROSCI.3415-17.2018. Epub 2019 Jan 9. PMID: 30626699
  • Guo S, Lu J, Zhuo Y, Xiao M, Xue X, Zhong S, Shen X, Yin C, Li L, Chen Q, Zhu M, Chen B, Zhao M, Zheng L, Tao Y, Yin H.* Endogenous cholesterol ester hydroperoxides modulate cholesterol levels and inhibit cholesterol uptake in hepatocytes and macrophages. Redox Biol. 2019 Feb; 21:101069. doi: 10.1016/j.redox.2018.101069. Epub 2018 Dec 12. PMID: 30576926
  • Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H.* Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation. J Clin Invest. 2019 Jan 2; 129(1):252-267. doi: 10.1172/JCI122064. Epub 2018 Dec 3. PMID: 30375985

2018

  • Zhang YY, Fu ZY, Wei J, Qi W, Baituola G, Luo J, Meng YJ, Guo SY, Yin H, Jiang SY, Li YF, Miao HH, Liu Y, Wang Y, Li BL, Ma YT, Song BL. A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption. Science. 2018 Jun 8; 360(6393):1087-1092. doi: 10.1126/science.aao6575. PMID: 29880681
  • Liu G, Gong Y, Zhang R, Piao L, Li X, Liu Q, Yan S, Shen Y, Guo S, Zhu M, Yin H, Funk CD, Zhang J, Yu Y. Resolvin E1 attenuates injury-induced vascular neointimal formation by inhibition of inflammatory responses and vascular smooth muscle cell migration. FASEB J. 2018 Oct; 32(10):5413-5425. doi: 10.1096/fj.201800173R. Epub 2018 May 3.PMID: 29723062
  • Li X, Cui XX, Chen YJ, Wu TT, Xu H, Yin H*, Wu YC*. Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function. Front Aging Neurosci. 2018 Apr 27; 10: 121. doi: 10.3389/fnagi.2018.00121. eCollection 2018.PMID: 29755339
  • Guo S, Li L, Yin H. Cholesterol Homeostasis and Liver X Receptor (LXR) in Atherosclerosis. Cardiovasc Hematol Disord Drug Targets. 2018; 18(1):27-33. doi: 10.2174/1871529X18666180302113713.PMID: 29512473
  • Huang, R.; Xue, X.; Li, S.; Wang, Y.; Sun, Y.; Liu, W.; Yin, H.*; Tao, T.*, Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats. Journal of cellular and molecular medicine 2018; 22: 3388-3396.
  • Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun J, Kong W. Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury. Nat Commun. 2018 Jan 2; 9(1):11. doi: 10.1038/s41467-017-02401-7.PMID: 29296021
  • He D, Zhao M, Wu C, Zhang W, Niu C, Yu B, Jin J, Ji L, Willard B, Mathew AV, Chen YE, Pennathur S, Yin H, He Y, Pan B, Zheng L. Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1. Redox Biol. 2018 May; 15:228-242. doi: 10.1016/j.redox.2017.11.027. Epub 2017 Dec 8. PMID: 29277016
  • Chen Q, Wang N, Zhu M, Lu J, Zhong H, Xue X, Guo S, Li M, Wei X, Tao Y, Yin H.* TiO2 nanoparticles cause mitochondrial dysfunction, activate inflammatory responses, and attenuate phagocytosis in macrophages: A proteomic and metabolomic insight. Redox Biol. 2018 May; 15:266-276. doi: 10.1016/j.redox.2017.12.011. Epub 2017 Dec 28. PMID: 2929443

2017

  • Xu L, Sinclair AJ, Faiza M, Li D, Han X, Yin H, Wang Y. Furan fatty acids - Beneficial or harmful to health? Prog Lipid Res. 2017 Oct; 68:119-137. doi: 10.1016/j.plipres.2017. 10.002. Epub 2017 Oct 16. PMID: 29051014
  • Cui Y, Shu XO, Li HL, Yang G, Wen W, Gao YT, Cai Q, Rothman N, Yin H, Lan Q, Xiang YB, Zheng W. Prospective study of urinary prostaglandin E2 metabolite and pancreatic cancer risk. Int J Cancer. 2017 Dec 15; 141(12):2423-2429. doi: 10.1002/ijc.31007. Epub 2017 Aug 29. PMID: 28815606
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