Dr Gigi P. C. Lo (盧沛芝博士)


Associate Professor

Dr Gigi P. C. Lo

Contact Information

Office: 1A-203, 2/F, Block 1,
To Yuen Building
Phone: +852 3442-4493
Fax: +852 3442-0549
Email: gigi.lo@cityu.edu.hk
Web: CityU Scholars

Research Interests

  • Photodynamic therapy
  • In vivo imaging
  • Nanomedicine
  • Molecular pharmaceutics
  • Theranostic agents

Dr Gigi Lo obtained her BSc degree in chemistry with first class honours and PhD degree from The Chinese University of Hong Kong (CUHK). She then went to the Division of Biophysics and Bioimaging of the Ontario Cancer Institute serving as a Postdoctoral Fellow for 2 years, where she developed her research interest in “smart” theranostic agents for cancer diagnosis and treatment. Before joining the City University of Hong Kong in 2015, she was appointed as a Research Assistant Professor in the Department of Chemistry of CUHK. She has published more than 70 papers in international peer-reviewed journals.

Research Interests

  1. Exploration of smart photosensitizers for targeted photodynamic therapy (PDT) and antimicrobial PDT
  2. Development of peptide-conjugated theranostic agents for in vivo cancer imaging and treatment
  3. Engineering mesoporous silica nanoparticles and polymeric micelles for multimodal cancer therapy
  4. Development of boron dipyrromethene based quenchers as key components of smart fluorescent probes for bioimaging
  5. Exploration of nanodrugs through self-assembly of molecular therapeutic agents for cancer therapy

Most Representative Publications in the Recent Five Years

(Total Number of Publications = 74; H-index = 31)

  1. D. Gao and P.-C. Lo*. “Polymeric Micelles Encapsulating pH-Responsive Doxorubicin Prodrug and Glutathione-activated Zinc(II) Phthalocyanine for Combined Chemotherapy and Photodynamic Therapy”, J. Controlled Release 2018, 282, 46-61.
  2. Y.-M. Zhou, Y.-K. Cheung, C. Ma, S. Zhao, D. Gao, P.-C. Lo,* W.-P. Fong, K.-S. Wong and D. K. P. Ng*. “Endoplasmic Reticulum-Localized Two-Photon-Absorbing Boron Dipyrromethenes as Advanced Photosensitizers for Photodynamic Therapy”, J. Med. Chem. 2018, 61, 3952-3961.
  3. S. Y. S. Chow, R. C. H. Wong, S. Zhao, P.-C. Lo* and D. K. P. Ng*. “Disulfide-Linked Dendritic Oligomeric Phthalocyanines as Glutathione-Responsive Photosensitizers for Photodynamic Therapy”, Chem. Eur. J. 2018, 24, 5779-5789.
  4. R. C. H. Wong, W.-P. Fong, D. K. P. Ng* and P.-C. Lo*. “Encapsulating pH-Responsive Doxorubicin-Phthalocyanine Conjugates in Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Controlled Chemotherapy”, Chem. Eur. J. 2017, 23, 16505-16515.
  5. R. C. H. Wong, S. Y. S. Chow, S. Zhao, W.-P. Fong, D. K. P. Ng* and P.-C. Lo*. “pH-Responsive Dimeric Zinc(II) Phthalocyanine in Mesoporous Silica Nanoparticles as an Activatable Nanophotosensitizing System for Photodynamic Therapy”, ACS Appl. Mater. Interfaces 2017, 9, 23487-23496.
  6. W.-J. Shi, P.-C. Lo,* S. Zhao, Q. Wang, W.-P. Fong and D. K. P. Ng*. “A Biotin-Conjugated Glutathione-Responsive FRET-Based Fluorescent Probe with a Ferrocenyl BODIPY as the Dark Quencher”, Dalton Trans. 2016, 45, 17798-17806.
  7. X.-J. Jiang, J. T. F. Lau, Q. Wang, D. K. P. Ng* and P.-C. Lo*. “pH- and Thiol-Responsive BODIPY-Based Photosensitizers for Targeted Photodynamic Therapy”, Chem. Eur. J. 2016, 22, 8273-8281.
  8. J. T. F. Lau, P.-C. Lo,* X.-J. Jiang, Q. Wang and D. K. P. Ng*. “A Dual Activatable Photosensitizer Toward Targeted Photodynamic Therapy”, J. Med. Chem.2014, 57, 4088-4097.
  9. M.-R. Ke, J. M. Eastel, K. L. K. Ngai, Y.-Y. Cheung, P. K. S. Chan, M. Hui,* D. K. P. Ng* and P.-C. Lo*. “Oligolysine-Conjugated Zinc(II) Phthalocyanines as Efficient Photosensitizers for Antimicrobial Photodynamic Therapy”, Chem. Asian J. 2014, 9, 1868-1875.
  10. H. He, P.-C. Lo* and D. K. P. Ng*. “A Glutathione-Activated Phthalocyanine-Based Photosensitizer for Photodynamic Therapy”, Chem. Eur. J. 2014, 20, 6241-6245. [This paper was rated as a Very Important Paper (VIP) and has a cover profile]
  11. M.-R. Ke, S.-L. Yeung, D. K. P. Ng,* W.-P. Fong and P.-C. Lo*. “Preparation and In Vitro Photodynamic Activities of Folate-Conjugated Distyryl Boron Dipyrromethene-Based Photosensitizers”, J. Med. Chem. 2013, 56, 8475-8483.
  12. J. T. F. Lau, X.-J. Jiang, D. K. P. Ng and P.-C. Lo*. “A Disulfide-Linked Conjugate of Ferrocenyl Chalcone and Silicon(IV) Phthalocyanine as an Activatable Photosensitiser”, Chem. Commun. 2013, 49, 4274-4276. (Appeared in the 2013 Emerging Investigators special issue)

Position Availability

We are looking for graduate students and research assistants with research experience in synthetic chemistry and molecular pharmaceutics for cancer diagnosis and therapy.

PhD students are encouraged to apply through the Hong Kong PhD Fellowship Scheme, Department of Biomedical Sciences PhD programme or the Interdisciplinary Programme in Veterinary Medicine (in collaboration with Cornell University).

Interested candidates should send a full resume and copies of academic credentials to Dr. Lo directly (gigi.lo@cityu.edu.hk).